Methods for treating bone cancer by administering a nerve growth factor antagonist antibody
First Claim
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1. A method for treating bone cancer pain in an individual comprising administering to the individual an effective amount of an anti-nerve growth factor (NGF) antagonist antibody, wherein the anti-NGF antagonist antibody comprises:
- a heavy chain variable region (VH) comprising a VH CDR1, VH CDR2, and VH CDR3 of the VH sequence shown in SEQ ID NO;
1; and
a light chain variable region (VL) comprising a VL CDR1, VL CDR2, and VL CDR3 of the VL sequence shown in SEQ ID NO;
2.
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Abstract
The invention features methods and compositions for preventing or treating bone cancer pain including cancer pain associated with bone metastasis by administering an antagonist of nerve growth factor (NGF). The NGF antagonist may be an anti-NGF (such as anti-hNGF) antibody that is capable of binding hNGF.
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10 Claims
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1. A method for treating bone cancer pain in an individual comprising administering to the individual an effective amount of an anti-nerve growth factor (NGF) antagonist antibody, wherein the anti-NGF antagonist antibody comprises:
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a heavy chain variable region (VH) comprising a VH CDR1, VH CDR2, and VH CDR3 of the VH sequence shown in SEQ ID NO;
1; anda light chain variable region (VL) comprising a VL CDR1, VL CDR2, and VL CDR3 of the VL sequence shown in SEQ ID NO;
2. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification