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Ketoreductase polypeptides for the production of ( R )-3-hydroxythiolane

DC CAFC
  • US 8,227,229 B2
  • Filed: 05/18/2011
  • Issued: 07/24/2012
  • Est. Priority Date: 08/24/2007
  • Status: Active Grant
First Claim
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1. An isolated or recombinant polynucleotide encoding an engineered ketoreductase polypeptide capable of stereoselectively reducing a 3-ketothiolane to (R)-3-hydroxythiolane with a percent stereomeric excess of at least 70%, which comprises an amino acid sequence that is at least 90% identical to a reference sequence based on SEQ ID NO:

  • 4 and which has at the residue corresponding to X145 a serine.

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