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Bivalent, bispecific antibodies

  • US 8,227,577 B2
  • Filed: 12/11/2008
  • Issued: 07/24/2012
  • Est. Priority Date: 12/21/2007
  • Status: Expired due to Fees
First Claim
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1. A bivalent, bispecific antibody, comprising:

  • a) the light chain and heavy chain of an antibody specifically binding to a first antigen, wherein heavy chain domain CH3 of the antibody specifically binding to a first antigen is replaced by a constant heavy chain domain CH1; and

    b) the light chain and heavy chain of an antibody specifically binding to a second antigen, wherein constant heavy chain domain CH3 of the antibody specifically binding to a second antigen is replaced by a constant light chain domain CL.

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