Neuromodulatory methods for treating pulmonary disorders
First Claim
1. A method for treating asthma in a subject, said method comprising the steps of:
- inserting a therapy delivery device into a subclavian artery or a subclavian vein of the subject;
advancing the therapy delivery device to a point substantially adjacent an intraluminal target site of the autonomic nervous system (ANS); and
activating the therapy delivery device to deliver a therapy signal to the intraluminal target site of the ANS to treat the asthma; and
wherein the intraluminal target site is in electrical communication with nervous tissue selected from the group consisting of a spinal nerve, pre- or post-ganglionic autonomic fibers, a sympathetic chain ganglion, a thoracic sympathetic chain ganglion, a cervical ganglion, a superior cervical ganglion, a middle cervical ganglion, a lower cervical ganglion, an inferior cervical ganglion, an intramural ganglion, an esophageal plexus, a cardiac plexus, a pulmonary plexus, an anterior pulmonary plexus, and a posterior pulmonary plexus.
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Abstract
A method for treating asthma in a subject includes inserting a therapy delivery device into a vessel of a subject. The therapy delivery device is advanced to a point substantially adjacent an intraluminal target site of the autonomic nervous system. Next, the therapy delivery device is activated to deliver a therapy signal to the intraluminal target site to treat the asthma. The intraluminal target site is in electrical communication with nervous tissue selected from the group consisting of a spinal nerve, pre- or post-ganglionic autonomic fibers, a sympathetic chain ganglion, a thoracic sympathetic chain ganglion, a cervical ganglion, a lower cervical ganglion, an inferior cervical ganglion, an intramural ganglion, a splanchnic nerve, an esophageal plexus, a cardiac plexus, a pulmonary plexus, an anterior pulmonary plexus, a posterior pulmonary plexus, a celiac plexus, a hypogastric plexus, an inferior mesenteric ganglion, a celiac ganglion, and a superior mesenteric ganglion.
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Citations
13 Claims
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1. A method for treating asthma in a subject, said method comprising the steps of:
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inserting a therapy delivery device into a subclavian artery or a subclavian vein of the subject; advancing the therapy delivery device to a point substantially adjacent an intraluminal target site of the autonomic nervous system (ANS); and activating the therapy delivery device to deliver a therapy signal to the intraluminal target site of the ANS to treat the asthma; and wherein the intraluminal target site is in electrical communication with nervous tissue selected from the group consisting of a spinal nerve, pre- or post-ganglionic autonomic fibers, a sympathetic chain ganglion, a thoracic sympathetic chain ganglion, a cervical ganglion, a superior cervical ganglion, a middle cervical ganglion, a lower cervical ganglion, an inferior cervical ganglion, an intramural ganglion, an esophageal plexus, a cardiac plexus, a pulmonary plexus, an anterior pulmonary plexus, and a posterior pulmonary plexus. - View Dependent Claims (2, 3)
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4. A method for treating asthma in a subject, said method comprising the steps of:
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inserting a therapy delivery device into a renal artery or a renal vein of the subject; advancing the therapy delivery device to a point substantially adjacent an intraluminal target site of the ANS; and activating the therapy delivery device to deliver a therapy signal to the intraluminal target site of the ANS to treat the asthma; wherein the intraluminal target site is in electrical communication with nervous tissue selected from the group consisting of a spinal nerve, pre- or post-ganglionic autonomic fibers, a sympathetic chain ganglion, an intramural ganglion, a splanchnic nerve, an esophageal plexus, a celiac plexus, a hypogastric plexus, an inferior mesenteric ganglion, a celiac ganglion, and a superior mesenteric ganglion. - View Dependent Claims (5)
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6. A method for treating asthma in a subject, said method comprising the steps of:
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inserting a therapy delivery device into an intercostal vein or an intercostal artery of the subject; advancing the therapy delivery device to a point substantially adjacent an intraluminal target site of the ANS; and activating the therapy delivery device to deliver a therapy signal to the intraluminal target site of the ANS to treat the asthma; wherein the intraluminal target site is in electrical communication with nervous tissue selected from the group consisting of a spinal nerve, pre- or post-ganglionic autonomic fibers, a sympathetic chain ganglion, a thoracic sympathetic chain ganglion, an intramural ganglion, a splanchnic nerve, an esophageal plexus, a cardiac plexus, a pulmonary plexus, an anterior pulmonary plexus, a posterior pulmonary plexus and a celiac plexus.
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7. A method for treating asthma in a subject, said method comprising the steps of:
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inserting a therapy delivery device into a jugular vein of the subject; advancing the therapy delivery device to a point substantially adjacent an intraluminal target site of the ANS; and activating the therapy delivery device to deliver a therapy signal to the intraluminal target site of the ANS to treat the asthma; wherein the intraluminal target site is in electrical communication with nervous tissue selected from the group consisting of a spinal nerve, pre- or post-ganglionic autonomic fibers, a sympathetic chain ganglion, a cervical ganglion, a superior cervical ganglion, a middle cervical ganglion, a lower cervical ganglion, an inferior cervical ganglion, and an intramural ganglion. - View Dependent Claims (8, 9)
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10. A method for treating asthma in a subject, said method comprising the steps of:
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inserting a therapy delivery device into a carotid artery of the subject; advancing the therapy delivery device to a point substantially adjacent an intraluminal target site of the ANS; and activating the therapy delivery device to deliver a therapy signal to the intraluminal target site of the ANS to treat the asthma; wherein the intraluminal target site is in electrical communication with nervous tissue selected from the group consisting of a spinal nerve, pre- or post-ganglionic autonomic fibers, a sympathetic chain ganglion, a cervical ganglion, a superior cervical ganglion, a middle cervical ganglion, a lower cervical ganglion, an inferior cervical ganglion, and an intramural ganglion. - View Dependent Claims (11, 12, 13)
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Specification