Methods for generating databases and databases for identifying polymorphic genetic markers
First Claim
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1. A method for determining whether a polymorphism correlates with a gene or pathway involved in the onset and progression of disease comprising:
- a) identifying a polymorphism in a first ethnic group, wherein a disease or biochemical pathway is known to occur in high frequency in the first ethnic group;
b) pooling samples obtained from healthy individuals from said first ethnic group, and pooling samples obtained from healthy individuals from a second ethnic group, wherein healthy individuals are selected only on the basis of being healthy, thereby providing pooled samples;
c) determining the frequency of the polymorphism in said pooled samples,d) determining a difference in frequency of the polymorphism in healthy individuals between said ethnic groups, wherein the polymorphism has not been correlated with a disease; and
e) associating the polymorphism with the disease or a biochemical pathway that occurs with high frequency in the first ethnic group.
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Abstract
Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.
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Citations
17 Claims
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1. A method for determining whether a polymorphism correlates with a gene or pathway involved in the onset and progression of disease comprising:
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a) identifying a polymorphism in a first ethnic group, wherein a disease or biochemical pathway is known to occur in high frequency in the first ethnic group; b) pooling samples obtained from healthy individuals from said first ethnic group, and pooling samples obtained from healthy individuals from a second ethnic group, wherein healthy individuals are selected only on the basis of being healthy, thereby providing pooled samples; c) determining the frequency of the polymorphism in said pooled samples, d) determining a difference in frequency of the polymorphism in healthy individuals between said ethnic groups, wherein the polymorphism has not been correlated with a disease; and e) associating the polymorphism with the disease or a biochemical pathway that occurs with high frequency in the first ethnic group. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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