System for analyzing thermal data based on breast surface temperature to determine suspect conditions

• US 8,231,542 B2
• Filed: 08/27/2009
• Issued: 07/31/2012
• Est. Priority Date: 08/27/2008
• Status: Expired due to Fees

• Current Assignee: Cyrcadia, Inc., First Clearing LLC (Wells Fargo & Company)
• Original Assignee: Lifeline Biotechnologies, Inc.
• Inventors: Keith, Louis G., Reeves, William H., Holmes, Jimmy D., Acharya U, Rajendra, Kwee, Ng Yin
• Primary Examiner(s): Hindenburg, Max
• Assistant Examiner(s): DANEGA, RENEE A
• Application Number:
  US12/583,969
• Publication Number:
  US 20100056946A1
• Time in Patent Office: 1,069 Days
• Field of Search: 600/549
• US Class Current: 600/549
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/7267 involving training the classification device
• CPC Class Codes: G16H 50/70 for mining of medical data, e.g. analysing previous cases of other patients

Abstract

A portable computing device or microprocessor/storage system including temperature sensors used to collect temperature readings of a breast tissue of a subject. The device would collect data from the sensors at regular time intervals over a period of time. All of the generated temperature data is stored in the portable computing or storage device. The sensors are placed on the greatest areas of interest on the breast, based on where most cancers develop, by using a sensor placeholder. The sensor placeholder would be lobate shaped, with the sensor placeholder aligning with the glandular regions of the breast where cancers are most likely to develop. The temperature data is then analyzed by one or more classifier systems and classified as either suspect or non-suspect tissue.

Claims

1. A system for analyzing a set of temperature readings of breast tissue of a subject to identify suspect tissue and non-suspect tissue, comprising:

a set of temperature sensors for sensing the set of temperature readings over a predetermined period, each temperature sensor among the set of temperature sensors placed at a predetermined position on a breast of the subject;

a storage system storing the set of temperature readings received from the set of temperature sensors; and

an ensemble of classifier systems including two or more classifier systems, the ensemble of classifier systems trained using one or more actual temperature readings including an above average temperature reading corresponding to suspect tissue, an average temperature reading corresponding to non-suspect tissue, and an anomalous temperature reading corresponding to non-suspect tissue, the ensemble of classifier systems receiving the set of temperature readings as an input, generating two or more output labels identifying the breast tissue as suspect tissue or non-suspect tissue, and combining the two or more output labels into a single diagnosis identifying the breast tissue as suspect tissue or non-suspect tissue, wherein a weight of each label from the two or more output labels determines a relative contribution of the label towards the single diagnosis.

2. The system as recited in claim 1, wherein suspect tissue includes cancerous tissue, benign tissue, and suspected cancerous tissue.

3. The system as recited in claim 1, wherein the ensemble of classifier systems is trained using the one or more actual temperature readings corresponding to one or more known output labels using one or more of supervised learning, unsupervised learning, or reinforcement learning.

4. The system as recited in claim 1, wherein the ensemble of classifier systems includes a neural network.

5. The system as recited in claim 4, wherein the neural network was trained using one or more actual temperature readings corresponding to one or more known output labels using either back-propagation or neuroevolution.

6. The system as recited in claim 1, wherein the ensemble of classifier systems includes two or more neural networks, each neural network among the two or more neural networks provided with different node weights, a different topology, or different activation functions or trained using a different set of one or more actual temperature readings corresponding to one or more known output labels.

7. The system as recited in claim 1, wherein the ensemble of classifier systems includes one or more of a back-propagation neural network, a neural network trained with neuroevolution, a radial basis function, a Gaussian mixture model, a fuzzy network, a neural network, and a support vector machine.

8. The system as recited in claim 1, wherein the predetermined period is 24 hours or less.

9. The system as recited in claim 1, further comprising a portable device including a microprocessor, the storage system contained within the portable device and controlled by the microprocessor, each temperature sensor connected to the portable device by a lead among a set of leads.

10. The system as recited in claim 9, wherein each lead is color coded based on the predetermined position where the temperature sensor will be placed on the breast.

11. The system as recited in claim 10, wherein each temperature sensor is labeled based on the predetermined position where the temperature sensor will be placed on the breast.

12. The system as recited in claim 9, wherein the set of temperature sensors are divided into a first group and a second group, each of the temperature sensors in the first group of temperature sensors being placed in the predetermined position on a left breast of the subject and each of the temperature sensors in the second group of temperature sensors being placed in the predetermined position on a right breast of the subject.

13. The system as recited in claim 1, wherein the set of temperature sensors are divided into a first group and a second group, one temperature sensor from the first group placed below a nipple of a left breast of the subject and one temperature sensor from the second group placed below a nipple of a right breast of the subject, one temperature sensor from the first group placed in an upper outer quadrant of the left breast and one temperature sensor from the second group placed in an upper outer quadrant of the right breast, one temperature sensor from the first group placed in an upper outer quadrant toward axilla associated with the left breast and one temperature sensor from the second group placed in an upper outer quadrant toward axilla associated with the right breast, one temperature sensor from the first group placed on an upper areola of the left breast and one temperature sensor from the second group placed on an upper areola of the right breast, one temperature sensor from the first group placed on a vertical midline above a horizontal midline of the left breast and one temperature sensor from the second group placed on a vertical midline above a horizontal midline of the right breast, one temperature sensor from the first group placed in an upper inner quadrant of the left breast and one temperature sensor from the second group placed in an upper inner quadrant of the right breast, one temperature sensor from the first group placed in an ambient temperature zone of the left breast and one temperature sensor from the second group placed in an ambient temperature zone of the right breast, and one temperature sensor from the first group placed in a flexible position of the left breast and one temperature sensor from the second group placed in a flexible position of the right breast.

14. The system as recited in claim 13, wherein the flexible position of the left breast and the flexible position of the right breast includes in an area of concern, near a palpable lesion, and in a contralateral position.

15. The system as recited in claim 1, further comprising a substantially lobate shaped sensor placeholder with a set of four appendages, each appendage among the four appendages forming a series of holes within each appendage, each hole among the series of holes serving as a location for placing one of the temperature sensors among the set of temperature sensors, and wherein a central area of the sensor placeholder forms a center hole for placement over a nipple of the breast to align the sensor placeholder.

16. The system as recited in claim 15, wherein the sensor placeholder is aligned on the breast with three of the four appendages positioned above the nipple.

17. The system as recited in claim 16, wherein a first sensor placeholder is aligned over a left breast and a second sensor placeholder is aligned over a right breast of the subject, wherein the set of temperature sensors are divided into a first group and a second group, one temperature sensor from the first group placed within a hole of a first appendage of the first sensor placeholder and below a nipple of the left breast and one temperature sensor from the second group placed within a hole of a first appendage of the second sensor placeholder and below a nipple of the right breast, one temperature sensor from the first group placed within a hole of a second appendage of the first sensor placeholder and in an upper outer quadrant of the left breast and one temperature sensor from the second group placed within a hole of a second appendage of the second placeholder and in an upper outer quadrant of the right breast, one temperature sensor from the first group placed within a second hole of a second appendage of the first sensor placeholder and in an upper outer quadrant toward axilla associated with the left breast and one temperature sensor from the second group placed within a second hole of a second appendage of the second sensor placeholder and in an upper outer quadrant toward axilla associated with the right breast, one temperature sensor from the first group placed within a hole of a third appendage of the first sensor placeholder and on an upper areola of the left breast and one temperature sensor from the second group placed within a hole of a third appendage of the second sensor placeholder and on an upper areola of the right breast, one temperature sensor from the first group placed within a second hole of a third appendage of the first sensor placeholder and on a vertical midline above a horizontal midline of the left breast and one temperature sensor from the second group placed within a second hole of a third appendage of the second sensor placeholder and on a vertical midline above a horizontal midline of the right breast, one temperature sensor from the first group placed within a hole of a fourth appendage of the first sensor placeholder and in an upper inner quadrant of the left breast and one temperature sensor from the second group placed within a hole of a fourth appendage of the second sensor placeholder and in an upper inner quadrant of the right breast, one temperature sensor from the first group placed within a hole of the set of four appendages of the first sensor placeholder and in an ambient temperature zone of the left breast and one temperature sensor from the second group placed within a hole of the set of four appendages of the second sensor placeholder and in an ambient temperature zone of the right breast, and one temperature sensor from the first group placed within a hole of the set of four appendages of the first sensor placeholder and in a flexible position of the left breast and one temperature sensor from the second group placed within a hole of the set of four appendages of the second sensor placeholder and in a flexible position of the right breast.

18. The system as recited in claim 1, wherein the set of temperature sensors is located on the subject, wherein the storage system and the ensemble of classifier systems is located in a remote location, further comprising a wireless transmitter transmitting the set of temperature readings to the storage system.

19. The system as recited in claim 1, wherein the set of temperature sensors and the storage system are located on the subject, further comprising a second storage system located in a remote location, the second storage system receiving the set of temperature readings from the storage system, and wherein the ensemble of classifier systems receives the set of temperature readings from the second storage system.

20. The system as recited in claim 1, wherein the ensemble of classifier systems is located in a remote location.

21. The system as recited in claim 1, further comprising a computer operating the ensemble of classifier systems, the computer including a user interface enabling a user of the computer to control operation of the ensemble of classifier systems and providing the user with a visual indication of the two or more output labels and the single diagnosis.

22. The system as recited in claim 21, wherein the user interface further provides a visual indication of a stage of breast cancer for the breast tissue identified as suspect tissue.

23. The system as recited in claim 21, wherein the visual indication includes a color indication.

24. The system as recited in claim 23, wherein the visual indication further includes a word indication.

25. A system for analyzing a set of temperature readings of breast tissue of a subject to identify suspect tissue and non-suspect tissue, comprising:

a set of temperature sensors for sensing the set of temperature readings over a predetermined period, each temperature sensor among the set of temperature sensors placed at a predetermined position on a breast of the subject; and

an ensemble of classifier systems including two or more classifier systems, the ensemble of classifier systems trained using one or more actual temperature readings including an above average temperature reading corresponding to suspect tissue, an average temperature reading corresponding to non-suspect tissue, and an anomalous temperature reading corresponding to non-suspect tissue, the ensemble of classifier systems receiving the set of temperature readings as an input, generating two or more output labels identifying the breast tissue as suspect tissue or non-suspect tissue, and combining the two or more output labels into a single diagnosis identifying the breast tissue as suspect tissue or non-suspect tissue, wherein a weight of each label from the two or more output labels determines a relative contribution of the label towards the single diagnosis.

26. The system as recited in claim 25, wherein suspect tissue includes cancerous tissue, benign tissue, and suspected cancerous tissue.

27. The system as recited in claim 25, wherein the ensemble of classifier systems includes a neural network.

28. The system as recited in claim 25, wherein the ensemble of classifier systems includes two or more neural networks, each neural network among the two or more neural networks provided with different node weights, a different topology, or different activation functions or trained using a different set of one or more actual temperature readings corresponding to one or more known output labels.

29. The system as recited in claim 25, wherein the ensemble of classifier systems includes one or more of a back-propagation neural network, a neural network trained with neuroevolution, a radial basis function, a Gaussian mixture model, a fuzzy network, a neural network, and a support vector machine.

30. The system as recited in claim 25, wherein the predetermined period is 24 hours or less.

31. The system as recited in claim 25, wherein the set of temperature sensors are divided into a first group and a second group, each of the temperature sensors in the first group of temperature sensors being placed in the predetermined position on a left breast of the subject and each of the temperature sensors in the second group of temperature sensors being placed in the predetermined position on a right breast of the subject.

32. The system as recited in claim 25, wherein the set of temperature sensors are divided into a first group and a second group, one temperature sensor from the first group placed below a nipple of a left breast of the subject and one temperature sensor from the second group placed below a nipple of a right breast of the subject, one temperature sensor from the first group placed in an upper outer quadrant of the left breast and one temperature sensor from the second group placed in an upper outer quadrant of the right breast, one temperature sensor from the first group placed in an upper outer quadrant toward axilla associated with the left breast and one temperature sensor from the second group placed in an upper outer quadrant toward axilla associated with the right breast, one temperature sensor from the first group placed on an upper areola of the left breast and one temperature sensor from the second group placed on an upper areola of the right breast, one temperature sensor from the first group placed on a vertical midline above a horizontal midline of the left breast and one temperature sensor from the second group placed on a vertical midline above a horizontal midline of the right breast, one temperature sensor from the first group placed in an upper inner quadrant of the left breast and one temperature sensor from the second group placed in an upper inner quadrant of the right breast, one temperature sensor from the first group placed in an ambient temperature zone of the left breast and one temperature sensor from the second group placed in an ambient temperature zone of the right breast, and one temperature sensor from the first group placed in a flexible position of the left breast and one temperature sensor from the second group placed in a flexible position of the right breast.

33. The system as recited in claim 32, wherein the flexible position of the left breast and the flexible position of the right breast includes in an area of concern, near a palpable lesion, and in a contralateral position.

34. The system as recited in claim 25, further comprising a substantially lobate shaped sensor placeholder with a set of four appendages, each appendage among the four appendages forming a series of holes within each appendage, each hole among the series of holes serving as a location for placing one of the temperature sensors among the set of temperature sensors, and wherein a central area of the sensor placeholder forms a center hole for placement over a nipple of the breast to align the sensor placeholder.

35. The system as recited in claim 34, wherein the sensor placeholder is aligned on the breast with three of the four appendages positioned above the nipple.

36. The system as recited in claim 35, wherein a first sensor placeholder is aligned over a left breast and a second sensor placeholder is aligned over a right breast of the subject, wherein the set of temperature sensors are divided into a first group and a second group, one temperature sensor from the first group placed within a hole of a first appendage of the first sensor placeholder and below a nipple of the left breast and one temperature sensor from the second group placed within a hole of a first appendage of the second sensor placeholder and below a nipple of the right breast, one temperature sensor from the first group placed within a hole of a second appendage of the first sensor placeholder and in an upper outer quadrant of the left breast and one temperature sensor from the second group placed within a hole of a second appendage of the second placeholder and in an upper outer quadrant of the right breast, one temperature sensor from the first group placed within a second hole of a second appendage of the first sensor placeholder and in an upper outer quadrant toward axilla associated with the left breast and one temperature sensor from the second group placed within a second hole of a second appendage of the second sensor placeholder and in an upper outer quadrant toward axilla associated with the right breast, one temperature sensor from the first group placed within a hole of a third appendage of the first sensor placeholder and on an upper areola of the left breast and one temperature sensor from the second group placed within a hole of a third appendage of the second sensor placeholder and on an upper areola of the right breast, one temperature sensor from the first group placed within a second hole of a third appendage of the first sensor placeholder and on a vertical midline above a horizontal midline of the left breast and one temperature sensor from the second group placed within a second hole of a third appendage of the second sensor placeholder and on a vertical midline above a horizontal midline of the right breast, one temperature sensor from the first group placed within a hole of a fourth appendage of the first sensor placeholder and in an upper inner quadrant of the left breast and one temperature sensor from the second group placed within a hole of a fourth appendage of the second sensor placeholder and in an upper inner quadrant of the right breast, one temperature sensor from the first group placed within a hole of the set of four appendages of the first sensor placeholder and in an ambient temperature zone of the left breast and one temperature sensor from the second group placed within a hole of the set of four appendages of the second sensor placeholder and in an ambient temperature zone of the right breast, and one temperature sensor from the first group placed within a hole of the set of four appendages of the first sensor placeholder and in a flexible position of the left breast and one temperature sensor from the second group placed within a hole of the set of four appendages of the second sensor placeholder and in a flexible position of the right breast.

37. The system as recited in claim 25, wherein the set of temperature sensors is located on the subject, wherein the ensemble of classifier systems is located in a remote location, further comprising a wireless transmitter transmitting the set of temperature readings to the ensemble of classifier systems.

38. The system as recited in claim 25, wherein the ensemble of classifier systems is located in a remote location.

39. The system as recited in claim 25, further comprising a computer operating the ensemble of classifier systems, the computer including a user interface enabling a user of the computer to control operation of the ensemble of classifier systems and providing the user with a visual indication of the two or more output labels and the single diagnosis.

40. The system as recited in claim 39, wherein the user interface further provides a visual indication of a stage of breast cancer for the breast tissue identified as suspect tissue.

41. The system as recited in claim 39, wherein the visual indication includes a color indication.

42. The system as recited in claim 41, wherein the visual indication further includes a word indication.

43. A system for analyzing a set of temperature readings of breast tissue of a subject to identify suspect tissue and non-suspect tissue, comprising:

a storage system storing the set of temperature readings, the set of temperature readings gathered over a predetermined period from a set of temperature sensors placed at a predetermined position on a breast of the subject; and

an ensemble of classifier systems including two or more classifier systems, the ensemble of classifier systems trained using one or more actual temperature readings including an above average temperature reading corresponding to suspect tissue, an average temperature reading corresponding to non-suspect tissue, and an anomalous temperature reading corresponding to non-suspect tissue, the ensemble of classifier systems receiving the set of temperature readings as an input, generating two or more output labels identifying the breast tissue as suspect tissue or non-suspect tissue, and combining the two or more output labels into a single diagnosis identifying the breast tissue as suspect tissue or non-suspect tissue, wherein a weight of each label from the two or more output labels determines a relative contribution of the label towards the single diagnosis.