Method of extending the shelf life of platelets using a composition comprising a short-to-ultrashort antiplatelet agent and anticoagulant and an oxygen carrier
First Claim
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1. A method of extending the shelf-life of platelets, comprising the steps of:
- (a) admixing a preservative composition with unactivated platelets to provide a preserved platelet composition; and
(b) storing the preserved platelet composition in an oxygen-permeable container or an oxygen-impermeable container,wherein the preservative composition comprises a single antiplatelet agent, an anticoagulant that reversibly inhibits factor IIa, and a hemoglobin-based oxygen carrier at a concentration range of 1-18 gm/dl, wherein said antiplatelet agent is eptifibatide.
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Abstract
The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.
22 Citations
20 Claims
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1. A method of extending the shelf-life of platelets, comprising the steps of:
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(a) admixing a preservative composition with unactivated platelets to provide a preserved platelet composition; and (b) storing the preserved platelet composition in an oxygen-permeable container or an oxygen-impermeable container, wherein the preservative composition comprises a single antiplatelet agent, an anticoagulant that reversibly inhibits factor IIa, and a hemoglobin-based oxygen carrier at a concentration range of 1-18 gm/dl, wherein said antiplatelet agent is eptifibatide. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of extending the shelf-life of platelets, comprising the steps of:
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(a) admixing a preservative composition with unactivated platelets to provide a preserved platelet composition; and (b) storing the preserved platelet composition in a container, wherein the preservative composition comprises a short-to-ultrashort acting antiplatelet agent, a short-to-ultrashort acting anticoagulant; and
an oxygen carrier. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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Specification