Pyrido(3,2-D)pyrimidines and pharmaceutical compositions useful for treating hepatitis C
1 Assignment
0 Petitions
Accused Products
Abstract
Specifically substituted pyrido(3,2-d)pyrimidine derivatives having the structural formula (I) are useful for the treatment of hepatitis C.
-
Citations
17 Claims
- 1. A compound having the structural formula:
-
7. A compound selected from the group consisting of:
-
2-acetamido-4-[(N-3-methyl-phenylcarbamoyl)-piperazin-1-yl]-6-(3,4-dimethoxyphenyl)-pyrido[3,2-d]pyrimidine, 2-amino-4-[(N-3-methyl-phenylcarbamoyl)-piperazin-1-yl]-6-(3,4-dimethoxyphenyl)-pyrido[3,2-d]pyrimidine, 2-amino-7-chloro-pyrido[3,2-d]pyrimidin-4(3H)one, 2-amino-7-(3,4-dimethoxyphenyl)-pyrido[3,2-d]pyrimidin-4(3H)one, 2-acetamido-7-(3,4-dimethoxyphenyl)-pyrido[3,2-d]pyrimidin-4(3H)one, 2-acetamido-4-(1,2,4-triazolyl)-7-(3,4-dimethoxyphenyl)-pyrido[3,2-d]pyrimidine, 2-amino-4-(N-3-methyl-phenyl-carbamoyl)-piperazin-1-yl])-7-(3,4-dimethoxyphenyl)-pyrido[3,2-d]pyrimidine, 2-amino-6-phenyl-pyrido[3,2-d]pyrimidin-4(3H)one, 2-acetamido-6-phenyl-pyrido[3,2-d]pyrimidin-4(3H)one, 2-acetamido-4-(1,2,4-triazolyl)-6-phenyl-pyrido[3,2-d]pyrimidine, 2-acetamido-4-(N-piperazin-1-yl)-6-phenyl-pyrido[3,2-d]pyrimidine, 2-acetamido-4-(N-morpholino)-6-(3,4-dimethoxyphenyl)-pyrido[3,2-d]pyrimidine, 2-acetamido-6-chloro-4-(2-ethoxyethoxy)-pyrido[3,2-d]pyrimidine, 2-acetamido-6-chloro-4-(2-methoxyethoxy)-pyrido[3,2-d]pyrimidine, 2-amino-4-(2-ethoxyethoxy)-6-(2-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2-amino-4-(2-ethoxyethoxy)-6-(3-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2-amino-4-(2-ethoxyethoxy)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2-amino-4-(2-methoxyethoxy)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2-acetamido-4-ethoxy-6-(3,4-dimethoxy)-pyrido[3,2-d]pyrimidine, 2-amino-4-trifluoroethoxy-6-chloro-pyrido(3,2-d)pyrimidine, 2-amino-4-ethoxy-6-chloro-pyrido(3,2-d)pyrimidine, 2-amino-4-(methoxy-ethoxy)-6-chloro-pyrido(3,2-d)pyrimidine, 2-amino-4-(isopropoxy)-6-chloro-pyrido(3,2-d)pyrimidine, 2-amino-4-(cyclopropylmethyloxy)-6-chloro-pyrido(3,2-d)pyrimidine, 2-amino-4-(4-morpholino-ethoxy)-6-chloro-pyrido(3,2-d)pyrimidine, 2-amino-4-(methoxy-ethoxy)-6-(p-acetamidophenyl)-pyrido(3,2-d)pyrimidine, 2-amino-4-(isopropoxy)-6-(p-acetamidophenyl)-pyrido(3,2-d)pyrimidine, 2-amino-4-(4-morpholino-ethoxy)-6-(p-acetamidophenyl)-pyrido(3,2-d)pyrimidine, 2-amino-4-[N-(4-pentenoyl)piperazin-1-yl]-6-(3,4-dimethoxyphenyl)-pyrido[3,2-d]pyrimidine, 2-amino-4-[4-(2-methylpropionyl)piperazin-1-yl]-6-(3,4-dimethoxyphenyl)-pyrido[3,2-d]pyrimidine, 2-amino-4-[4-(3,3-dimethylbutyryl)piperazin-1-yl]-6-(3,4-dimethoxyphenyl)-pyrido[3,2-d]pyrimidine, 2-amino-4-[4-(N-butylcarbamoyl)piperazin-1-yl]-6-(3,4-dimethoxy-phenyl)-pyrido[3,2-d]pyrimidine, 2-amino-4-{4-[N-(tert-butoxycarbonyl)glycyl]piperazin-1-yl}-6-(3,4-di-methoxyphenyl)-pyrido[3,2-d]pyrimidine, 2-amino-4-(N-piperazin-1-yl)-6-(4-fluorophenyl)-pyrido-[3,2-d]pyrimidine, 2-amino-4-[4-(2-naphthoxy-acetyl)piperazin-1-yl]-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2-amino-4-[4-(3-methylphenoxy-acetyl)piperazin-1-yl]-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2-amino-4-[4-(3-chlorophenoxy-acetyl)piperazin-1-yl]-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2-amino-4-[4-(2,4-dichlorophenoxy-acetyl)piperazin-1-yl]-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2-amino-4-[4-(4-fluorophenoxy-acetyl)piperazin-1-yl]-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2-amino-4-[4-(4-bromophenoxy-acetyl)piperazin-1-yl]-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2-acetylamino-4-(N-piperazin-1-yl)-6-chloro-pyrido[3,2-d]pyrimidine, 2-amino-4-(N-piperazin-1-yl)-6-chloro-pyrido[3,2-d]pyrimidine, 2-amino-4-[4-(4-chlorophenoxy-acetyl)piperazin-1-yl]-6-chloro-pyrido[3,2-d]pyrimidine, 2-amino-4-[N-(4-chlorophenoxyacetyl)piperazin-1-yl]-6-(4-cyanophenyl)pyrido-[3,2-d]pyrimidine, 2-amino-4-[N-(4-chlorophenoxyacetyl)piperazin-1-yl]-6-(4-trifluoromethylphenyl)-pyri-do-[3,2-d]pyrimidine, 2-amino-4-[N-(4-chlorophenoxyacetyl)piperazin-1-yl]-6-(3-fluorophenyl)pyrido-[3,2-d]pyrimidine, 2-amino-4-[N-(4-chlorophenoxyacetyl)piperazin-1-yl]-6-(furan-3-yl)pyrido-[3,2-d]pyrimidine, 2-amino-4-[N-(4-chlorophenoxyacetyl)piperazin-1-yl]-6-(thiophen-3-yl)pyrido-[3,2-d]pyrimidine, 2-amino-4-[N-(4-chlorophenoxyacetyl)piperazin-1-yl]-6-(3,4-difluorophenyl)pyrido-[3,2-d]pyrimidine, 2-amino-4-[N-(4-chlorophenoxyacetyl)piperazin-1-yl]-6-(4-chlorophenyl)pyrido-[3,2-d]pyrimidine, 2-amino-4-[N-(4-chlorophenoxyacetyl)piperazin-1-yl]-6-(3-chlorophenyl)pyrido-[3,2-d]pyrimidine, 2-amino-4-[N-(4-chlorophenoxyacetyl)piperazin-1-yl]-6-(pyridin-4-yl)pyrido-[3,2-d]pyrimidine, 2-amino-4-[N-(4-chlorophenoxyacetyl)piperazin-1-yl]-6-(3-chloro-4-fluorophenyl)-pyri-do-[3,2-d]pyrimidine, 2-amino-4-[N-(4-chlorophenoxyacetyl)piperazin-1-yl]-6-(propen-1-yl)pyrido-[3,2-d]pyrimidine, 2-amino-6-(4-fluorophenyl)-pyrido(3,2-d)pyrimidin-4(3H)thione, 2-amino-4-thiomethyl-6-(4-fluorophenyl)-pyrido(3,2-d)pyri-midine, 2-amino-4-thioethyl-6-(4-fluorophenyl)pyrido(3,2-d)pyrimidine, 2-amino-4-thioisopropyl-6-(4-fluorophenyl)pyrido(3,2-d)pyrimidine, 2-amino-4-(2-methoxy-thioethyl)-6-(4-fluorophenyl)pyrido(3,2-d)pyrimidine, 2-acetamido-4-ethylamino-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-acetamido-4-isopropylamino-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-acetamido-4-(2-methoxy-ethylamino)-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-acetamido-4-[3,4-(methylenedioxy)anilino]-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-acetamido-4-(thiomorpholino-1,1-dioxide)-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-acetamido-4-(tetrahydro-3-thiophen-amino-1,1-dioxide)-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-amino-4-ethylamino-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-amino-4-isopropylamino-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-amino-4-(2-methoxyethylamino)-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-amino-4-[3,4-(methylenedioxy)anilino]-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-amino-4-(thiomorpholino-1,1-dioxide)-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-amino-4-(tetrahydro-3-thiophen-amine-1,1-dioxide)-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-acetamido-4-[1-(4-acetyl-piperazin-1-yl)-3-amino-propan-1-one)]-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-acetamido-4-[2-amino-1-(4-methylpiperazin-1-yl)ethanone]-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-acetamido-4-(3-methanesulfonyl-propylamino)-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-acetamido-4-(2-amino-ethylmethylsulfone)-6-(4-fluorophenyl)pyrido[3,2-d]pyri-midine, 2-amino-4-[1-(4-acetyl-piperazin-1-yl)-3-amino-propan-1-one]-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-amino-4-[2-amino-1-(4-methylpiperazin-1-yl)ethanone]-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-amino-4-[(3-methanesulfonyl)-propylamino]-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-amino-4-[(2-amino-ethyl)methylsulfone]-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-amino-4-(2-butoxy-ethoxy)-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-amino-4-(2-fluoro-ethoxy)-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-amino-4-[2-(methoxyethoxy)ethoxy]-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-amino-4-(2-chloro-benzyloxy)-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-amino-4-(4-fluoro-benzyloxy)-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-amino-4-(3-methyl-benzyloxy)-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-amino-4-(4-trifluoromethyl-benzyloxy)-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-amino-4-(4-cyano-benzyloxy)-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidin-4(3H)one, 4-chloro-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 4-amino-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine), 4-morpholino-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 4-phenoxy-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 4-ethoxy-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 4-[3,4-(methylenedioxy)anilino]-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 4-[2-(N,N-dimethylamino)ethoxy]-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 4-(2-methoxyethoxy)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 3-amino-6-(4-fluorophenyl)-pyridine-2-carboxylic acid amide, 2-methyl-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidin-4(3H)one, 2-ethyl-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidin-4(3H)one, 2-chloromethyl-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidin-4(3H)one, 2-methyl-4-chloro-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2-methyl-4-(N,N-diethylamino)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 3-amino-6-(3-fluorophenyl)-pyridine-2-carboxylic acid amide, 2,4-dihydroxy-6-(3-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2,4-dihydroxy-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2,4-dichloro-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2-methyl-4-amino-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimi-dine, 2,4-diethoxy-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2,4-diisopropoxy-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimi-dine, 2,4-di-(2-methoxy-ethoxy)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2-methyl-4-(2-methoxyethoxy)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2-chloro-4-(3-methoxypropylamino)-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine, 2-chloro-4-ethylamino-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2-ethyl-4-(2-methoxyethoxy)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2-chloro-4-isopropoxy-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine, 2-methyl-4-ethoxy-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimi-dine, N-(4,6-dichloro-pyrido[3,2-d]pyrimidin-2-yl)-acetamide, 6-chloro-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 4-ethoxy-6-phenyl-pyrido[3,2-d]pyrimidin-2-ylamine, 4-ethoxy-6-pyridin-4-yl-pyrido[3,2-d]pyrimidin-2-ylamine, 4-ethoxy-6-p-tolyl-pyrido[3,2-d]pyrimidin-2-ylamine, 4-ethoxy-6-(4-trifluoromethyl-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamine, 4-ethoxy-6-(3-fluoro-4-methoxy-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(3,4-difluoro-phenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 4-ethoxy-6-(4-methoxy-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(3-chloro-4-fluoro-phenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(4-chloro-phenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(4-chloro-3-fluoro-phenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(4-amino-phenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 4-(2-amino-4-ethoxy-pyrido[3,2-d]pyrimidin-6-yl)-benzonitrile, 4-Ethoxy-6-thiophen-2-yl-pyrido[3,2-d]pyrimidin-2-ylamine, 6-chloro-4-[1,2,4]triazol-1-yl-pyrido[3,2-d]pyrimidin-2-ylamine, 6-chloro-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-2-ylamine, 4,6-bis-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(3,4-dimethoxy-phenyl)-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-2-ylamine, 4-(2-methoxy-ethoxy)-6-phenyl-pyrido[3,2-d]pyrimidin-2-ylamine, 4-(2-methoxy-ethoxy)-6-pyridin-4-yl-pyrido[3,2-d]pyrimidin-2-ylamine, 4-(2-methoxy-ethoxy)-6-p-tolyl-pyrido[3,2-d]pyrimidin-2-ylamine, 4-(2-methoxy-ethoxy)-6-(4-trifluoromethyl-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(3-fluoro-4-methoxy-phenyl)-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(3,4-difluoro-phenyl)-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-2-ylamine, 4-ethoxy-6-(4-methoxy-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(3-chloro-4-fluoro-phenyl)-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(4-chloro-phenyl)-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(4-amino-phenyl)-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-2-ylamine, 4-(2-methoxy-ethoxy)-6-thiophen-2-yl-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(4-chloro-3-fluoro-phenyl)-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-2-ylamine, 4-[2-amino-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-6-yl]-phenol, 2-[2-amino-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-6-yl]-phenol, 6-(2,4-difluoro-phenyl)-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-2-ylamine, N-{4-[2-amino-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-6-yl]-phenyl}-2,2-dimethyl-propionamide, 6-(4-methanesulfonyl-phenyl)-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-2-ylamine, N-{4-[2-amino-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-6-yl]-phenyl}-isobutyramide, 6-(2,4-dimethyl-thiazol-5-yl)-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(5,6-dihydro-4H-[1,3]oxazin-2-yl)-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(4-isopropoxy-phenyl)-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-2-ylamine, 4-(2-methoxy-ethoxy)-6-(morpholine-4-sulfonyl)-pyrido[3,2-d]pyrimidin-2-ylamine, {4-[2-amino-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-6-yl]-phenyl}-methanol, {4-[2-amino-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-6-yl]-phenyl}-acetonitrile, N-{4-[2-amino-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-6-yl]-phenyl}-methanesulfonamide, N-{4-[2-Amino-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-6-yl]-benzyl}-acetamide, N-{4-[2-Amino-4-(2-methoxy-ethoxy)-pyrido[3,2-d]pyrimidin-6-yl]-benzyl}-methanesulfonamide, 6-chloro-4-morpholin-4-yl-pyrido[3,2-d]pyrimidin-2-ylamine, N-[4-(2-amino-4-morpholin-4-yl-pyrido[3,2-d]pyrimidin-6-yl)-phenyl]-acetamide, N-[4-(2-amino-4-morpholin-4-yl-pyrido[3,2-d]pyrimidin-6-yl)-phenyl]-isobutyramide, 6-(4-amino-phenyl)-4-morpholin-4-yl-pyrido[3,2-d]pyrimidin-2-ylamine, N-[4-chloro-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-2-yl]-acetamide, 6-(4-fluoro-phenyl)-4-methoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(4-fluoro-phenyl)-4-(N-2-methoxyethyl-N-methyl)-pyrido[3,2-d]pyrimidine-2,4-diamine, N-[2-amino-6-(4-fluoro-phenyl)-pyrido[3,2-d]pyrimidin-4-yl]-O-ethyl-hydroxylamine, 6-(2-methoxyphenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-[4-(N-methylamido)-phenyl]-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-[4-(N-cyclopropylamido)-phenyl]-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2,4-bis(trifluoromethyl)phenyl]-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(4-methylsulphonylphenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(3-chlorophenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(furan-2-yl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(thiophen-3-yl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(4-(morpholinomethyl)phenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2,3-dichlorophenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2-(trifluoromethyl)phenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2-ethoxyphenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2,5-difluorophenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(3-cyanophenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(3,5-difluorophenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2-chlorophenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(3,5-di(trifluoromethyl)phenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(pyrazol-4-yl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2-fluoro-pyridin-3-yl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2,3,4-trifluorophenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2-benzyloxyphenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2,4,6-trimethylphenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(3-fluoro,4-methoxyphenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2-methyl,4-fluorophenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(4-hydroxyphenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(4-dimethylaminophenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2-chloro-4-trifluoromethyl-phenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(4-chloro-3-trifluoromethylphenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(quinolin-3-yl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(4-benzyloxyphenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2-chloro-5-trifluoromethylphenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2-cyanothiophen-5-yl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2,3-difluorophenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2-methylphenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(3-trifluoromethylphenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2,4-dichlorophenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(3,5-dimethylphenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(3,4,5-trifluorophenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(5-chlorothiophen-2-yl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2-methoxypyridin-5-yl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2,4-dichlorophenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(3,5-dichlorophenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(3-ethoxyphenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2,4-difluorophenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2-chloro-4-fluorophenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(1-benzothiophen-2-yl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(furan-3-yl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(2-methoxy-5-fluorophenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, 6-(pyrazol-3-yl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, and 6-(1-benzofuran-2-yl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine, or a pharmaceutically acceptable addition salt or a stereochemical isomeric form thereof or a N-oxide thereof.
-
- 14. A method of treatment of an infection due to a virus from the Flaviridae family comprising the step of administering a patient in need thereof of a therapeutic amount of a compound having the structural formula:
Specification