Methods for detection of cardiac arrhythmias

• US 8,233,973 B2
• Filed: 05/02/2008
• Issued: 07/31/2012
• Est. Priority Date: 05/02/2008
• Status: Active Grant

• Current Assignee: Spacelabs Healthcare Ltd. (OSI Systems Incorporated)
• Original Assignee: Spacelabs Healthcare LLC (OSI Systems Incorporated)
• Inventors: Stewart, Donald-Bane
• Primary Examiner(s): Getzow, Scott
• Assistant Examiner(s): PATTON, AMANDA K
• Application Number:
  US12/114,692
• Publication Number:
  US 20090275849A1
• Time in Patent Office: 1,551 Days
• Field of Search: 600508-521
• US Class Current: 600/518
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/02455 provided with high/low alarm devices
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 5/361 Detecting fibrillation
• CPC Class Codes: A61B 5/364 Detecting abnormal ECG interval, e.g. extrasystoles, ectopic heartbeats

Abstract

A method for calculating a variability value that is indicative of AF by obtaining a signal sequence of a plurality of RR intervals by monitoring electrical activity of a patient'"'"'s heart. Each RR interval is converted into an instantaneous heart rate value and sorted into ascending order. The difference between each successive heart rate is calculated, discarding the two largest differences. The variability value is calculated by adding the retained differences.

Claims

1. A method for calculating a variability value that is indicative of AF using a sequence of RR intervals, comprising the steps of:

obtaining a signal sequence comprising a plurality of RR intervals wherein said signal sequence is obtained by monitoring the time intervals between successive heart beats of a patient'"'"'s heart by measuring at least one of electrical activity;

acoustic activity;

trans-thoracic impedance;

blood pressure;

blood velocity;

blood oxygenation;

heart movement and/or deformation;

converting each RR interval in said sequence into an instantaneous heart rate value;

sorting said instantaneous heart rate values into ascending order;

calculating differences between each of said sorted successive instantaneous heart rates;

determining two largest differences of said calculated differences;

discarding said two largest differences generated in the previous step; and

calculating a variability value by adding differences which were not discarded.

2. The method of claim 1, further comprising the steps of segmenting said RR interval sequence into a plurality of segments and generating a variability value for each said segment.

3. The method of claim 2, further comprising the step of filtering said generated variability value for at least one segment using previous or successive segment variability values.

4. The method of claim 3 wherein said filtering is implemented by a 7-sample median filter.

5. The method of claim 2, further comprising the steps of comparing at least one said variability value to at least one threshold.

6. The method of claim 5 wherein said step of comparing at least one said variability value to at least one threshold comprises comparing at least one said variability value to an AF detection threshold or an AF start/end threshold.

7. The method of claim 6, wherein after said step of comparing at least one said variability value to at least one threshold, a corresponding segment is flagged as ‘

probably containing AF’

when said detection threshold is exceeded and an AF event is detected when a pre-determined number of consecutive segments are flagged as ‘

probably containing AF’ and

a corresponding segment is flagged as ‘

AF extension permitted’

when said start/end threshold is exceeded.

8. The method of claim 7, wherein once an AF event has been detected, previous and/or following segments are tested for the AF extension permitted flag and, if found, the detected AF event is extended to include said segment(s).

9. The method of claim 8, further comprising the step of validating each detected AF event.

10. The method of claim 1 wherein RR intervals shorter than 180 milliseconds or longer than 2 seconds are discarded from the variability calculation.

11. The method of claim 1, further comprising the step of reducing said variability value if said sequence contains no heart rate interval greater than a heart rate threshold.

12. The method of claim 11 wherein said heart rate threshold is 60 beats per minute.

13. The method of claim 11 wherein said reduction is implemented by halving said variability value.

14. The method of claim 1, further comprising the step of limiting said variability value if said sequence is identified as containing a heart rate trend.

15. The method of claim 14 wherein said heart rate trend is identified by, for each instantaneous heart rate of an RR interval, if the heart rate is significantly greater or less than the previous interval heart rate, defining the start of a trend.

16. The method of claim 15 wherein a trend is determined to persist until an RR interval with a significant heart-rate change in an opposite direction is detected.

17. The method of claim 16 wherein, once a new trend is determined on a RR interval, all intervals in a previous trend are flagged as being of the previous trend type.

18. The method of claim 17 wherein each RR interval in a trend is flagged as being a member of a long heart rate if a consecutive number of RR interval trend flags exceeds a long heart rate threshold.

19. The method of claim 18 wherein each RR interval in a trend is flagged as being a member of a short heart rate if a consecutive number of RR interval trend flags exceeds a lower short heart rate threshold.

20. The method of claim 19 wherein each RR interval in a trend is flagged as being not trended if no threshold conditions apply.

21. The method of claim 20 where, for a plurality of RR intervals, trend flags are tested to establish whether said plurality is dominated by heart trend behavior.

22. The method of claim 21 wherein said testing is performed by assigning each long heart rate trend flag a count.

23. The method of claim 22 wherein said testing is performed by assigning each short heart rate trend flag a count less than said count of the long heart rate trend flag.

24. The method of claim 23 wherein said testing is performed by assigning each non trend flag a count less than said count of the short heart rate trend flag.

25. The method of claim 24 wherein an average of said long heart rate trend count, short heart rate trend count, and non-trend count is taken.

26. The method of claim 25 wherein if said average is below a first threshold, said plurality of RR intervals is determined to have no trend.

27. The method of claim 26 wherein if said average is greater than a second threshold, said plurality of RR intervals is determined to have a strong trend.

28. The method of claim 27 wherein if said average is between said first and said second thresholds, said plurality of RR intervals is determined to have an unknown trend.

29. The method of claim 16 wherein significantly is defined as a difference greater than 5 beats-per-minute or 4% of the current heart rate.

30. The method of claim 9 wherein said step of validating each detected AF event comprises assigning individual trend flags within that event, summing individual trend flags, and discarding the AF event as false detection where the average count over the AF event is greater than a predefined threshold.

31. A method for calculating a variability value that is indicative of AF using a sequence of NN intervals, comprising the steps of:

obtaining a signal sequence comprising a plurality of NN intervals wherein said signal sequence is obtained via monitoring the time intervals between successive heart beats of a patient'"'"'s heart by measuring and analyzing at least one of electrical activity;

acoustic activity;

trans-thoracic impedance;

blood pressure;

blood velocity;

blood oxygenation;

heart movement and/or deformation;

converting each NN interval in said sequence into an instantaneous heart rate value;

sorting said instantaneous heart rate values into ascending order;

calculating differences between each of said sorted successive instantaneous heart rates;

determining two largest differences of said calculated differences;

discarding said two largest differences, thereby leaving a plurality of retained differences; and

calculating a variability value by adding the retained differences.