Systems and methods for model-based estimation of cardiac ejection fraction, cardiac contractility, and ventricular end-diastolic volume
First Claim
1. A method for estimating beat-by-beat cardiovascular parameters and variables, comprising:
- processing one or more cycles of arterial blood pressure information to determine intra-beat and inter-beat variability in blood pressure; and
computing estimates of one or more cardiovascular parameters and variables from the intra-beat variability, the inter-beat variability, beat-by-beat estimates of stroke volume, and a ventricular pressure-volume model;
wherein the cardiovascular parameters and variables include at least one of a beat-by-beat pre-ejection ventricular compliance, a beat-by-beat end-diastolic compliance, a beat-by-beat end-systolic ventricular compliance, and a beat-by-beat peak-systolic compliance, determined for at least one of the left and right ventricle and computing estimates comprises optimization of an error criterion.
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Accused Products
Abstract
The methods and systems for estimating cardiac ejection fraction, cardiac contractility, and ventricular end-diastolic volume on a beat-by-beat basis include observing arterial blood pressure waveforms to determine ventricular compliances for a pressure-volume loop in the ventricle. Uncalibrated or calibrated cardiac ejection fraction may be calculated from estimates of stroke volume and the ventricular compliances. Cardiac contractility may be calculated from estimates of a ventricular compliance. Uncalibrated or calibrated ventricular end-diastolic volume may also be calculated from estimates of stroke volume and the ventricular compliances. A set of calibration parameters for calibrating cardiac ejection fraction or ventricular end-diastolic volume may be estimated in a least-squares manner.
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Citations
58 Claims
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1. A method for estimating beat-by-beat cardiovascular parameters and variables, comprising:
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processing one or more cycles of arterial blood pressure information to determine intra-beat and inter-beat variability in blood pressure; and computing estimates of one or more cardiovascular parameters and variables from the intra-beat variability, the inter-beat variability, beat-by-beat estimates of stroke volume, and a ventricular pressure-volume model; wherein the cardiovascular parameters and variables include at least one of a beat-by-beat pre-ejection ventricular compliance, a beat-by-beat end-diastolic compliance, a beat-by-beat end-systolic ventricular compliance, and a beat-by-beat peak-systolic compliance, determined for at least one of the left and right ventricle and computing estimates comprises optimization of an error criterion. - View Dependent Claims (2, 3, 4, 5, 6, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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7. A method for estimating beat-by-beat cardiovascular parameters and variables, comprising:
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processing one or more cycles of arterial blood pressure information to determine intra-beat and inter-beat variability in blood pressure; and computing estimates of one or more cardiovascular parameters and variables from the intra-beat variability, the inter-beat variability, beat-by-beat estimates of stroke volume, and a ventricular pressure-volume model, wherein the cardiovascular parameters and variables include an uncalibrated beat-by-beat ejection fraction; and computing calibrated beat-by-beat ejection fraction from the uncalibrated beat-by-beat ejection fraction using one or more calibration parameters, wherein the calibration parameters are computed using an optimization criterion. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16)
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30. A system for estimating beat-to-beat cardiac output comprising:
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a blood pressure measuring device; a processor; a display; a user interface; and a memory storing computer executable instructions, which when executed by the processor cause the processor to; receive one or more cycles of arterial blood pressure information from the blood pressure measuring device; receive beat-to-beat estimates of stroke volume; analyze one or more cycles of arterial blood pressure information to determine intra-beat and inter-beat variability in blood pressure; compute estimates of one or more cardiovascular parameters and variables from the intra-beat variability, the inter-beat variability, beat-to-beat estimates of stroke volume, and a ventricular pressure-volume model; and display the estimates; wherein the cardiovascular parameters and variables include at least one of a beat-by-beat pre-ejection ventricular compliance, a beat-by-beat end-diastolic compliance, a beat-by-beat end-systolic ventricular compliance, and a beat-by-beat peak-systolic compliance, determined for at least one of the left and right ventricle and computing estimates comprises optimization of an error criterion. - View Dependent Claims (31, 32, 33, 34, 35, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58)
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36. A system for estimating beat-to-beat cardiac output comprising:
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a blood pressure measuring device; a processor; a display; a user interface; and a memory storing computer executable instructions, which when executed by the processor cause the processor to; receive one or more cycles of arterial blood pressure information from the blood pressure measuring device; receive beat-to-beat estimates of stroke volume; analyze one or more cycles of arterial blood pressure information to determine intra-beat and inter-beat variability in blood pressure; compute estimates of one or more cardiovascular parameters and variables from the intra-beat variability, the inter-beat variability, beat-to-beat estimates of stroke volume, and a ventricular pressure-volume model, wherein the cardiovascular parameters and variables include an uncalibrated beat-by-beat ejection fraction; and compute calibrated beat-by-beat ejection fraction from the uncalibrated beat-by-beat ejection fraction using one or more calibration parameters, wherein the calibration parameters are computed using an optimization criterion. - View Dependent Claims (37, 38, 39)
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Specification