Humanized antibodies specific for von Willebrand factor
First Claim
Patent Images
1. A humanized antibody or an antigen binding fragment thereof specific for von Willebrand factor (vWF), the humanized antibody or antigen binding fragment thereof comprising:
- (a) the heavy chain variable region sequence as set forth in SEQ ID NO;
19; and
(b) the light chain variable region sequence as set forth in SEQ ID NO;
28.
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Abstract
The present disclosure relates to humanized antibodies or binding fragments thereof specific for human von Willebrand factor (vWF), methods for their preparation and use, including methods for treating vWF mediated diseases or disorders.
47 Citations
126 Claims
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1. A humanized antibody or an antigen binding fragment thereof specific for von Willebrand factor (vWF), the humanized antibody or antigen binding fragment thereof comprising:
- (a) the heavy chain variable region sequence as set forth in SEQ ID NO;
19; and
(b) the light chain variable region sequence as set forth in SEQ ID NO;
28. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60)
- (a) the heavy chain variable region sequence as set forth in SEQ ID NO;
-
2. A humanized antibody or binding fragment thereof specific for vWF, the humanized antibody comprising:
- (a) a heavy chain sequence as set forth in SEQ ID NO;
237; and
(b) a light chain sequence as set forth in SEQ ID NO;
238.
- (a) a heavy chain sequence as set forth in SEQ ID NO;
-
16. An isolated nucleic acid encoding a humanized antibody or binding fragment thereof specific for vWF that comprises a heavy chain variable region sequence as set forth in SEQ ID NO:
- 19 and a light chain variable region sequence as set forth in SEQ ID NO;
28.
- 19 and a light chain variable region sequence as set forth in SEQ ID NO;
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17. An isolated nucleic acid encoding a humanized antibody or binding fragment thereof specific for vWF that comprises a heavy chain sequence as set forth in SEQ ID NO:
- 237 and a light chain sequence as set forth in SEQ ID NO;
238.
- 237 and a light chain sequence as set forth in SEQ ID NO;
- 61. A humanized antibody or an antigen binding fragment thereof specific for von Willebrand factor (vWF), the humanized antibody or antigen binding fragment thereof comprising a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises the sequence as set forth in SEQ ID NO:
- 94. A humanized antibody or an antigen binding fragment thereof specific for von Willebrand factor (vWF), the humanized antibody or antigen binding fragment thereof comprising a heavy chain variable region and a light chain variable region, wherein the light chain variable region comprises the sequence as set forth in SEQ ID NO:
Specification