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Glipizide compositions

  • US 8,236,352 B2
  • Filed: 11/05/2003
  • Issued: 08/07/2012
  • Est. Priority Date: 10/01/1998
  • Status: Expired due to Fees
First Claim
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1. A composition comprising:

  • (a) nanoparticles of spray-dried glipizide or a salt thereof, wherein the glipizide nanoparticles have an effective average particle size of less than 2000 nm; and

    (b) at least one surface stabilizer adsorbed on the surface of the glipizide nanoparticles;

    wherein;

    (i) the surface stabilizer is free of intermolecular cross-linkages;

    (ii) the glipizide nanoparticles or a salt thereof is present in an amount of from about 99.5% to about 0.001%, by weight, based on the total combined weight of the glipizide nanoparticles or a salt thereof and at least one surface stabilizer, not including other excipients;

    (iii) the at least one surface stabilizer is present in an amount of from about 0.5% to about 99.999% by weight, based on the total combined dry weight of the glipizide nanoparticles or a salt thereof and at least one surface stabilizer, not including other excipients;

    (iv) upon administration to a mammal, the glipizide nanoparticles redisperse such that the nanoparticles have an effective average particle size of less than 2 microns; and

    (v) the composition exhibits a Cmax which is at least 50% greater than the Cmax exhibited by a non-nanoparticulate glipizide composition when administered at the same dosage.

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