Cyclopamine analogues and methods of use thereof
First Claim
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1. A process comprising:
- a. reacting a first compound of formula 2;
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Abstract
The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
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15 Claims
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1. A process comprising:
a. reacting a first compound of formula 2; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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