Ophthalmic device comprising a holographic sensor

• US 8,241,574 B2
• Filed: 07/28/2011
• Issued: 08/14/2012
• Est. Priority Date: 01/07/2000
• Status: Expired due to Fees

• Current Assignee: Smart Holograms Ltd.
• Original Assignee: Smart Holograms Ltd.
• Inventors: Burles, Barry, Millington, Roger Bradley, Lowe, Christopher Robin, Kabilan, Satyamoorthy, Blyth, Jeffrey
• Primary Examiner(s): Sines, Brian J
• Application Number:
  US13/192,992
• Publication Number:
  US 20110286064A1
• Time in Patent Office: 383 Days
• Field of Search: 422/55, 422/56, 422/82.05, 436/528, 436/529, 436/530, 436/531, 436/164, 436/165, 436/169, 600/300, 600/318, 600/319, 600/316
• US Class Current: 422/82.05
• CPC Class Codes: A61B 3/125 with contact lenses contact lenses per se G02C7/04
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: G01N 2021/758 using reversible reaction
• CPC Class Codes: G01N 2021/7723 Swelling part, also for adsorption sensor, i.e. without chemical reaction
• CPC Class Codes: G01N 2021/7773 Reflection
• CPC Class Codes: G01N 21/75 Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated systems in which material is burnt in a flame or plasma G01N21/72, G01N21/73
• CPC Class Codes: G01N 21/77 by observing the effect on a chemical indicator
• CPC Class Codes: G01N 21/78 producing a change of colour
• CPC Class Codes: G03H 1/0248 Volume holograms
• CPC Class Codes: G03H 1/0406 Image plane or focused image holograms, i.e. an image of the object or holobject is formed on, in or across the recording plane
• CPC Class Codes: G03H 1/0408 Total internal reflection [TIR] holograms, e.g. edge lit or substrate mode holograms
• CPC Class Codes: G03H 1/18 Particular processing of hologram record carriers, e.g. for obtaining blazed holograms photographic processing in general G03C, G03D
• CPC Class Codes: G03H 1/2249 Holobject properties
• CPC Class Codes: G03H 1/265 Angle multiplexing; Multichannel holograms G03H1/268 takes precedence
• CPC Class Codes: G03H 1/28 superimposed holograms only
• CPC Class Codes: G03H 2001/0044 holographic fringes deformations; holographic sensors holographic rain sensor in vehicles B60S1/084
• CPC Class Codes: G03H 2001/0415 for recording reflection holograms
• CPC Class Codes: G03H 2001/0432 Constrained record wherein, during exposure, the recording means undergoes constrains substantially differing from those expected at reconstruction
• CPC Class Codes: G03H 2001/186 Swelling or shrinking the holographic record or compensation thereof, e.g. for controlling the reconstructed wavelength G03H2001/0033, G03H2250/44 take precedence
• CPC Class Codes: G03H 2001/2263 : Multicoloured holobject
• CPC Class Codes: G03H 2001/2284 : Superimposing the holobject with other visual information
• CPC Class Codes: G03H 2001/2615 : in physical contact, i.e. layered holograms
• CPC Class Codes: G03H 2001/2655 : Time multiplexing, i.e. consecutive records wherein the period between records is pertinent per se
• CPC Class Codes: G03H 2001/266 : Wavelength multiplexing
• CPC Class Codes: G03H 2210/20 : 2D object
• CPC Class Codes: G03H 2210/22 : 2D SLM object wherein the object beam is formed of the light modulated by the SLM SLM per se G03H2001/0224
• CPC Class Codes: G03H 2210/30 : 3D object
• CPC Class Codes: G03H 2210/45 : Representation of the decomposed object
• CPC Class Codes: G03H 2210/52 : Alphanumerical
• CPC Class Codes: G03H 2210/63 : Environment affecting the recording, e.g. underwater G03H2001/0432 takes precedence
• CPC Class Codes: G03H 2250/40 : Printed information overlapped with the hologram
• CPC Class Codes: G03H 2270/12 : Fibrous, e.g. paper, textile
• CPC Class Codes: G03H 2270/55 : being an optical element, e.g. spectacles

Abstract

An ophthalmic device which comprises a holographic element comprising a medium comprising a phenylboronic acid group and, disposed therein, a hologram, wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium, and wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid.

Claims

1. An ophthalmic device which comprises a holographic element comprising a medium comprising a phenylboronic acid group and, disposed therein, a reflection hologram,

wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium,

wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid, and

wherein an image of the reflection hologram is responsive to invisible radiation.

2. The device according to claim 1, wherein the medium consists essentially of a polymer comprising the phenylboronic acid group.

3. The device according to claim 2, wherein the medium consists of the polymer comprising the phenylboronic acid group.

4. The device according to claim 1, wherein the phenylboronic acid group is selected from the group consisting of:

5. The device according to claim 1, wherein the phenylboronic acid group is selected from the group consisting of:

6. The device according to claim 1, wherein the holographic element does not contain silver.

7. The device according to claim 1, wherein the interaction is a reversible chemical reaction.

8. The device according to claim 1, wherein the analyte is glucose.

9. The device according to claim 1, wherein the medium is a polymer of monomers including acrylamide.

10. The device according to claim 1, wherein the medium is a polymer of monomers including 3-acrylamidophenylboronic acid.

11. The device according to claim 10, wherein the medium comprises a group which is capable of repelling lactate, the group comprising a substantial negative charge.

12. The device according to claim 10, wherein the medium comprises an amine group.

13. The device according to claim 1, wherein the ophthalmic device is a contact lens.