Multiphasic biofunctional nano-components and methods for use thereof
First Claim
1. A multiphasic nano-component comprising a first phase and at least one additional phase that is compositionally distinct from said first phase, wherein said first phase defines a first spatially discrete compartment of the nano-component and said at least one additional phase defines a second spatially discrete compartment, wherein said first phase and said at least one additional phase are oriented in the nano-component to provide an anisotropic morphology so that said first compartment and said second compartment have a side-by-side orientation and said first phase and said at least one additional phase each have an exposed surface, wherein at least one of said first phase and said additional phase comprises a pharmaceutically and/or cosmetically acceptable polymer, and wherein at least one of said first phase and said additional phase comprises an active ingredient.
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Abstract
Multiphasic nano-components (MPNs) having at least two phases and at least one active ingredient are provided. The MPNs can be used in various methods for medical diagnostics or with pharmaceutical, personal care, oral care, and/or nutritional compositions, for example, in oral care, hair, or skin products. The MPNs can be designed to have targeted delivery within an organism, while providing controlled release systems or combining incompatible active ingredients. Further, the MPNs can be used as biomedical coatings (such as anti-microbial coatings), or anti-corrosive coatings, bioimaging probes with combined diagnostic and therapeutic use, and fragrance release systems, among others. The MPNs can be formed by electrified jetting of polymers.
64 Citations
18 Claims
- 1. A multiphasic nano-component comprising a first phase and at least one additional phase that is compositionally distinct from said first phase, wherein said first phase defines a first spatially discrete compartment of the nano-component and said at least one additional phase defines a second spatially discrete compartment, wherein said first phase and said at least one additional phase are oriented in the nano-component to provide an anisotropic morphology so that said first compartment and said second compartment have a side-by-side orientation and said first phase and said at least one additional phase each have an exposed surface, wherein at least one of said first phase and said additional phase comprises a pharmaceutically and/or cosmetically acceptable polymer, and wherein at least one of said first phase and said additional phase comprises an active ingredient.
- 17. A multiphasic nano-component comprising a first phase and at least one additional phase that is compositionally distinct from said first phase, wherein said first phase defines a first spatially discrete compartment of the nano-component and said at least one additional phase defines a second spatially discrete distinct compartment of the nano-component, wherein said first phase and said at least one additional phase are oriented in the nano-component to provide an anisotropic morphology so that said first compartment and said second compartment have a side-by-side orientation and said first phase and said at least one additional phase each have an exposed surface, wherein said first phase comprises a first pharmaceutically and/or cosmetically acceptable polymer and said additional phase comprises a second distinct pharmaceutically and/or cosmetically acceptable polymer, and wherein at least one of said first phase and said additional phase comprises an active ingredient.
Specification