Treating a tumor or the like with electric fields at different frequencies

• US 8,244,345 B2
• Filed: 04/21/2005
• Issued: 08/14/2012
• Est. Priority Date: 04/23/2004
• Status: Active Grant

• Current Assignee: Novocure GmbH (NovoCure Limited)
• Original Assignee: NovoCure Limited
• Inventors: Palti, Yoram
• Primary Examiner(s): Lavert, Nicole F
• Application Number:
  US11/111,423
• Publication Number:
  US 20050240228A1
• Time in Patent Office: 2,672 Days
• Field of Search: 607/2, 607/154
• US Class Current: 607/2
• CPC Class Codes: A61N 1/326 for promoting growth of cells, e.g. bone cells
• CPC Class Codes: A61N 1/40 Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals

Abstract

Cells that are in the late anaphase or telophase stages of cell division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages rapidly dividing cells like tumor cells, but does not harm normal cells that are not dividing. Improved results may be achieved by using a field with two or more frequencies.

Claims

1. A method of selectively destroying or inhibiting the growth of rapidly dividing cells located within a target region of a patient, comprising the steps of:

(a) imposing a first AC electric field in the target region of the patient, the first electric field having a first frequency, wherein the first electric field has frequency characteristics that correspond to a vulnerability of the rapidly dividing cells, wherein the first electric field is strong enough to damage, during late anaphase or telophase stages of cell division, a significant portion of the rapidly dividing cells whose long axis is generally aligned with lines of force of the first electric field, and wherein the first electric field leaves non-dividing cells located within the target region substantially unchanged;

(b) imposing a second AC electric field in the target region of the patient, the second electric field having a second frequency that is different from the first frequency, wherein the second electric field has frequency characteristics that correspond to a vulnerability of the rapidly dividing cells, wherein the second electric field is strong enough to damage, during the late anaphase or telophase stages of cell division, a significant portion of the rapidly dividing cells whose long axis is generally aligned with lines of force of the second electric field, and wherein the second electric field leaves non-dividing cells located within the target region substantially unchanged; and

(c) repeating steps (a) and (b) until a therapeutically significant portion of the rapidly dividing cells die,

wherein step (a) is implemented during a first interval of time and step (b) is implemented during a second interval of time, wherein the first interval of time and the second interval of time are mutually exclusive, and wherein the frequencies of the first and second electric fields are between about 50 kHz and about 500 kHz.

2. The method of claim 1, wherein the first and second electric fields are imposed in the target region via insulated electrodes.

3. The method of claim 1, wherein the strength of the first and second electric fields in at least a portion of the target region is between about 0.1 V/cm and about 10 V/cm.

4. The method of claim 1, wherein the frequencies of the first and second electric fields are between about 100 kHz and about 300 kHz.

5. The method of claim 4, wherein the strength of the first and second electric fields in at least a portion of the target region is between about 1 V/cm and about 5 V/cm.

6. The method of claim 1, wherein the frequency of the first electric field is about 170 kHz and the frequency of the second electric field is about 250 kHz.

7. The method of claim 6, wherein the strength of the first and second electric fields in at least a portion of the target region is between about 1 V/cm and about 5 V/cm.

8. A method of selectively destroying or inhibiting the growth of rapidly dividing cells located within a target region of a patient, comprising the steps of:

(a) imposing a first AC electric field in the target region of the patient, the first electric field having a first frequency, wherein the first electric field has frequency and amplitude characteristics that cause the first electric field to selectively damage cells that are undergoing cell division and leave cells that are not undergoing cell division substantially unharmed;

(b) imposing a second AC electric field in the target region of the patient, the second electric field having a second frequency that is different from the first frequency, wherein the second electric field has frequency and amplitude characteristics that cause the second electric field to selectively damage cells that are undergoing cell division and leave cells that are not undergoing cell division substantially unharmed; and

(c) repeating steps (a) and (b) until a therapeutically significant portion of the rapidly dividing cells die,

wherein step (a) is implemented during a first interval of time and step (b) is implemented during a second interval of time, wherein the first interval of time and the second interval of time are mutually exclusive, and wherein the frequencies of the first and second electric fields are between about 50 kHz and about 500 kHz.

9. The method of claim 8, wherein the first and second electric fields are imposed in the target region via insulated electrodes.

10. The method of claim 8, wherein the strength of the first and second electric fields in at least a portion of the target region is between about 0.1 V/cm and about 10 V/cm.

11. The method of claim 8, wherein the frequencies of the first and second electric fields are between about 100 kHz and about 300 kHz.

12. The method of claim 11, wherein the strength of the first and second electric fields in at least a portion of the target region is between about 1 V/cm and about 5 V/cm.

13. The method of claim 8, wherein the frequency of the first electric field is about 170 kHz and the frequency of the second electric field is about 250 kHz.

14. The method of claim 13, wherein the strength of the first and second electric fields in at least a portion of the target region is between about 1 V/cm and about 5 V/cm.

15. A method of selectively destroying or inhibiting the growth of rapidly dividing cells located within a target region of a patient, comprising the steps of:

subjecting a target region to AC electric fields at a plurality of different frequencies, wherein the electric fields have frequency and field strength characteristics that cause the electric fields to selectively damage cells that are undergoing cell division, and wherein the electric fields leave cells that are not undergoing cell division substantially unharmed; and

repeating the subjecting step until a therapeutically significant portion of the rapidly dividing cells die,

wherein the electric fields at the plurality of different frequencies are applied sequentially, and wherein the frequencies of the electric fields are between about 50 kHz and about 500 kHz.

16. The method of claim 15, wherein the target region is subjected to the electric fields via insulated electrodes.

17. The method of claim 15, wherein the strength of the electric fields in at least a portion of the target region is between about 0.1 V/cm and about 10 V/cm.

18. The method of claim 15, wherein the frequencies of the electric fields are between about 100 kHz and about 300 kHz.

19. The method of claim 18, wherein the strength of the electric fields in at least a portion of the target region is between about 1 V/cm and about 5 V/cm.

20. A method of selectively destroying or inhibiting the growth of rapidly dividing cells located within a target region of a patient, comprising the steps of:

(a) imposing a first AC electric field in the target region of the patient, the first electric field having a first frequency, wherein the first electric field has frequency characteristics that correspond to a vulnerability of the rapidly dividing cells, wherein the first electric field is strong enough to damage, during late anaphase or telophase stages of cell division, a significant portion of the rapidly dividing cells whose long axis is generally aligned with lines of force of the first electric field, and wherein the first electric field leaves non-dividing cells located within the target region substantially unchanged;

(b) imposing a second AC electric field in the target region of the patient, the second electric field having a second frequency that is different from the first frequency, wherein the second electric field has frequency characteristics that correspond to a vulnerability of the rapidly dividing cells, wherein the second electric field is strong enough to damage, during the late anaphase or telophase stages of cell division, a significant portion of the rapidly dividing cells whose long axis is generally aligned with lines of force of the second electric field, and wherein the second electric field leaves non-dividing cells located within the target region substantially unchanged; and

(c) repeating steps (a) and (b) until a therapeutically significant portion of the rapidly dividing cells die,

wherein step (a) and step (b) are implemented simultaneously.

21. The method of claim 20, wherein the first and second electric fields are imposed in the target region via insulated electrodes.

22. The method of claim 20, wherein the frequencies of the first and second electric fields are between about 50 kHz and about 500 kHz.

23. The method of claim 22, wherein the strength of the first and second electric fields in at least a portion of the target region is between about 0.1 V/cm and about 10 V/cm.

24. The method of claim 20, wherein the frequencies of the first and second electric fields are between about 100 kHz and about 300 kHz.

25. The method of claim 24, wherein the strength of the first and second electric fields in at least a portion of the target region is between about 1 V/cm and about 5 V/cm.

26. The method of claim 20, wherein the frequency of the first electric field is about 170 kHz and the frequency of the second electric field is about 250 kHz.

27. The method of claim 26, wherein the strength of the first and second electric fields in at least a portion of the target region is between about 1 V/cm and about 5 V/cm.

28. A method of selectively destroying or inhibiting the growth of rapidly dividing cells located within a target region of a patient, comprising the steps of:

(a) imposing a first AC electric field in the target region of the patient, the first electric field having a first frequency, wherein the first electric field has frequency and amplitude characteristics that cause the first electric field to selectively damage cells that are undergoing cell division and leave cells that are not undergoing cell division substantially unharmed;

(b) imposing a second AC electric field in the target region of the patient, the second electric field having a second frequency that is different from the first frequency, wherein the second electric field has frequency and amplitude characteristics that cause the second electric field to selectively damage cells that are undergoing cell division and leave cells that are not undergoing cell division substantially unharmed; and

(c) repeating steps (a) and (b) until a therapeutically significant portion of the rapidly dividing cells die,

wherein step (a) and step (b) are implemented simultaneously.

29. The method of claim 28, wherein the first and second electric fields are imposed in the target region via insulated electrodes.

30. The method of claim 28, wherein the frequencies of the first and second electric fields are between about 50 kHz and about 500 kHz.

31. The method of claim 30, wherein the strength of the first and second electric fields in at least a portion of the target region is between about 0.1 V/cm and about 10 V/cm.

32. The method of claim 28, wherein the frequencies of the first and second electric fields are between about 100 kHz and about 300 kHz.

33. The method of claim 32, wherein the strength of the first and second electric fields in at least a portion of the target region is between about 1 V/cm and about 5 V/cm.

34. The method of claim 28, wherein the frequency of the first electric field is about 170 kHz and the frequency of the second electric field is about 250 kHz.

35. The method of claim 34, wherein the strength of the first and second electric fields in at least a portion of the target region is between about 1 V/cm and about 5 V/cm.

36. A method of selectively destroying or inhibiting the growth of rapidly dividing cells located within a target region of a patient, comprising the steps of:

subjecting a target region to AC electric fields at a plurality of different frequencies, wherein the electric fields have frequency and field strength characteristics that cause the electric fields to selectively damage cells that are undergoing cell division, and wherein the electric fields leave cells that are not undergoing cell division substantially unharmed; and

repeating the subjecting step until a therapeutically significant portion of the rapidly dividing cells die,

wherein the electric fields at the plurality of different frequencies are applied simultaneously.

37. The method of claim 36, wherein the target region is subjected to the electric fields via insulated electrodes.

38. The method of claim 36, wherein the frequencies of the electric fields are between about 50 kHz and about 500 kHz.

39. The method of claim 38, wherein the strength of the electric fields in at least a portion of the target region is between about 0.1 V/cm and about 10 V/cm.

40. The method of claim 36, wherein the frequencies of the electric fields are between about 100 kHz and about 300 kHz.

41. The method of claim 40, wherein the strength of the electric fields in at least a portion of the target region is between about 1 V/cm and about 5 V/cm.