System and method for conditional biventricular pacing

• US 8,244,354 B2
• Filed: 02/26/2010
• Issued: 08/14/2012
• Est. Priority Date: 02/27/2009
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Sweeney, Michael O., Sheldon, Todd J.
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Stice, Paula J
• Application Number:
  US12/713,499
• Publication Number:
  US 20100222834A1
• Time in Patent Office: 900 Days
• Field of Search: 607/2, 607/9, 607 14- 15, 607/17, 607/25
• US Class Current: 607/14
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61N 1/36578 controlled by mechanical motion of the heart wall, e.g. measured by an accelerometer or microphone
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation
• CPC Class Codes: A61N 1/3688 configured for switching the pacing mode, e.g. from AAI to DDD
• CPC Class Codes: A61N 1/3714 Atrial capture

Abstract

An implantable pacing system with single, double and triple chamber pacing capabilities, provided individually or in concert on a conditional or continuous basis depending upon ongoing analyses of atrial rhythm status, atrioventricular conduction status and ventricular rate. A mode is selected to reduce the occurrence of any ventricular pacing in favor of intrinsic atrioventricular and ventricular conduction. If excessively long PR intervals are occurring too frequently or atrioventricular conduction is unreliable or absent, the implantable pulse generator is operated in a conditional triple chamber pacing mode that provides atrial-synchronous biventricular pacing in every cardiac cycle for a period of time as necessary to restore and maintain AV synchrony, while minimizing ventricular asynchrony otherwise associated with monochamber RV pacing as in conventional dual chamber pacing systems. Similarly, biventricular pacing is provided in every cardiac cycle when ventricular rates are undesirably slow during atrial fibrillation, where AV synchronization is excluded.

Claims

1. A medical device, comprising:

an atrial pacing lead;

a right ventricular lead;

a left ventricular lead; and

a microprocessor operably coupled with the atrial pacing lead, the right ventricular lead and left ventricular lead and configured to receive cardiac signals from the leads and to provide pacing stimuli according to a minimal bi-ventricular pacing protocol (MBVP) in the absence of atrial fibrillation (AF) and to provide pacing stimuli according to a conditional triple chamber pacing protocol (CTCP) if AF is present.

2. The device of claim 1, wherein the microprocessor is further configured to determine AV intervals and in response to the atrial fibrillation not being present determine whether AV decoupling is present based upon the AV intervals, and to operate the device in the CTCP mode if the AV decoupling is determined to be present.

3. The device of claim 2, wherein the microprocessor is further configured to determine a presence of AV uncoupling based upon ventricular activity, and operate the device in the CTCP mode if the AV uncoupling is determined to be present.

4. The device of claim 1, wherein the microprocessor determines AV intervals in response to the atrial fibrillation not being present, and determines whether AV decoupling is present based upon the AV intervals, and operates the device in the CTCP mode if the AV decoupling is determined to be present.

5. The device of claim 4, wherein the microprocessor is configured to operate the device in the conditional triple chamber pacing mode in response to both AF not being sensed and a predetermined high burden circumstance being identified.

6. The device of claim 5, wherein the predetermined high burden circumstance is one of an indication of sleep and an indication of exercise.

7. The device claim 4, wherein the microprocessor determines whether an AV interval burden associated with the sensed AV intervals is greater than a predetermined threshold, and identifies one or more predetermined high burden circumstance, wherein AV decoupling is determined to be present in response to one of the AV interval burden associated with the sensed AV intervals being greater than the predetermined threshold and the predetermined high burden circumstance being present.

8. The device of claim 7, wherein the predetermined high burden circumstance is an indication of one or more of atrial pacing, increasing atrial pacing percentage, and upward change in programmed atrial pacing rate.

9. The device of claim 4, wherein the microprocessor collects AV interval data prior to operating the device in the MBVP mode in order to establish a longitudinal AV interval baseline across a diversity of time and physiologic circumstances.

10. The device of claim 4, wherein the microprocessor determines the presence of AV uncoupling based upon sensed ventricular activity, and operates the device in the CTCP mode if the AV uncoupling is determined to be present.

11. The device of claim 10, wherein the microprocessor determines whether a predetermined number of the sensed AV intervals exceed a first threshold during a predetermined time period, and determines that the AV uncoupling is present if the predetermined number is greater than a second threshold.

12. The device of claim 10, wherein the microprocessor monitors the number of cardiac cycles that are devoid of sensed ventricular activity, and determines AV uncoupling to be present if X of Y of the monitored number of cardiac cycles are devoid of sensed ventricular activity.

13. The device of claim 10, wherein the microprocessor determines whether an AV interval burden is greater than a predetermined threshold, and determines the AV uncoupling to be present in response to the AV interval burden being greater than the predetermined threshold and predetermined high burden circumstance being present.

14. The device of claim 13, wherein the predetermined high burden circumstance is an indication of one or more of atrial pacing, increasing atrial pacing percentage, and upward change in programmed atrial pacing rate.

15. A non-transitory computer readable medium having computer executable instructions for performing a method in a medical device, the method comprising:

operating the device in a minimal biventricular pacing (MBVP) mode;

sensing cardiac signals;

determining whether atrial fibrillation is present in response to the sensed cardiac signals; and

operating the device in a conditional triple chamber pacing (CTCP) mode if atrial fibrillation is present.

16. A method of delivering therapy in a medical device, the method comprising:

operating the device in a minimal biventricular pacing (MBVP) mode;

sensing cardiac signals;

determining whether atrial fibrillation is present in response to the sensed cardiac signals; and

operating the device in a conditional triple chamber pacing (CTCP) mode if atrial fibrillation is present.

17. The method of claim 16, further comprising:

sensing AV intervals;

determining, in response to atrial fibrillation not being present, whether the AV decoupling is present based upon the sensed AV intervals; and

operating the device in the CTCP mode if AV decoupling is determined to be present.

18. The method of claim 17, further comprising:

identifying predictably recurring predetermined high burden AV decoupling circumstances; and

operating the device in the conditional triple chamber pacing mode if the predetermined high burden circumstance is identified.

19. The method of claim 18, wherein the predetermined high burden circumstance is one of an indication of sleep and an indication of exercise.

20. The method of claim 17, further comprising:

determining whether an AV interval burden associated with the sensed AV intervals is greater than a predetermined threshold; and

identifying one or more predetermined high burden circumstance, wherein the AV decoupling is determined to be present in response to one of the AV interval burden associated with the sensed AV intervals being greater than the predetermined threshold and a predetermined high burden circumstance being present.

21. The method of claim 20, wherein the predetermined high burden circumstance is an indication of one or more of atrial pacing, increasing atrial pacing percentage, and upward change in programmed atrial pacing rate.

22. The method of claim 17, further comprising collecting AV interval data prior to operating the device the MBVP mode in order to establish a longitudinal AV interval baseline across a diversity of time and physiologic circumstances.

23. The method of claim 17, further comprising:

sensing ventricular activity;

determining a presence of the AV uncoupling based upon the sensed ventricular activity; and

operating the device in the CTCP mode if AV uncoupling is determined to be present.

24. The method of claim 23, further comprising determining whether a predetermined number of the sensed AV intervals exceed a first threshold during a predetermined time period and determining that AV decoupling is present if the predetermined number is greater than a second threshold.

25. The method of claim 23, wherein the method further comprises monitoring the number of cardiac cycles that are devoid of sensed ventricular activity, wherein AV uncoupling is determined to be present if X of Y of the monitored number of cardiac cycles are devoid of sensed ventricular activity.

26. The method of claim 23, further comprising:

determining whether an AV interval burden is greater than a predetermined threshold; and

identifying the presence of a predetermined high burden circumstance, wherein AV decoupling is determined to be present in response to the AV interval burden being greater than the predetermined threshold and the predetermined high burden circumstance being present.

27. The method of claim 26, wherein the predetermined high burden circumstance is an indication of one or more of atrial pacing, increasing atrial pacing percentage, and upward change in programmed atrial pacing rate.