Implantable intraocular pressure drain

• US 8,246,569 B1
• Filed: 08/16/2005
• Issued: 08/21/2012
• Est. Priority Date: 08/17/2004
• Status: Active Grant

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: Chen, Po-Jui, Rodger, Damien, Tai, Yu-Chong, Humayun, Mark, Meng, Ellis Fan-chuin
• Primary Examiner(s): Zalukaeva, Tatyana
• Assistant Examiner(s): Wiest, Philip R
• Application Number:
  US11/205,757
• Time in Patent Office: 2,562 Days
• Field of Search: 604/537, 604/539, 604 8- 10, 604/290, 604/106, 604/107, 604/246, 604/247, 604/264, 604/523, 604/294
• US Class Current: 604/8
• CPC Class Codes: A61B 2562/0247 Pressure sensors
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 2562/12 Manufacturing methods specially adapted for producing sensors for in-vivo measurements
• CPC Class Codes: A61B 3/16 for measuring intraocular pressure, e.g. tonometers
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61B 5/6821 Eye
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: F16K 2099/0086 Medical applications
• CPC Class Codes: F16K 99/0009 the valve element held by multiple arms
• CPC Class Codes: F16K 99/0057 the fluid being the circulating fluid itself, e.g. check valves

Abstract

An implanted parylene tube shunt relieves intra-ocular pressure. The device is implanted with an open end in the anterior chamber of the eye, allowing excess fluid to be drained through the tube out of the eye. In one embodiment, only a first end of the tube implanted into the anterior chamber of the eye is open. Intra-ocular pressure (IOP) is then monitored, for example utilizing an implanted sensor. When IOP exceeds a critical value, a practitioner intervenes, puncturing with a laser a thinned region of the tube lying outside the eye, thereby initiating drainage of fluid and relieving pressure. In accordance with alternative embodiments, the both ends of the tube are open, and the tube includes a one-way valve configured to permit drainage where IOP exceeds the critical value. The tube may include projecting barbs to anchor the tube in the eye without the need for sutures.

Claims

1. An intra-ocular pressure drain comprising:

a hollow tube consisting essentially of parylene and having i) an open end for implantation into an eye, ii) thinned regions of the hollow tube along a length thereof in a portion of the hollow tube positioned to lie outside the eye and iii) a closed end in the portion positioned to lie outside the eye.

2. The intra-ocular pressure drain of claim 1 further comprising a barb projecting from the parylene.

3. The intra-ocular pressure drain of claim 1 wherein the tube has a bend.

4. The intra-ocular pressure drain of claim 1 further comprising a foldable arm projecting from the hollow tube.

5. The intra-ocular pressure drain of claim 4 wherein an end of the foldable arm is rounded.

6. The intra-ocular pressure drain of claim 1, further comprising a sensor for measuring intra-ocular pressure.

7. The intra-ocular pressure drain of claim 1, wherein the thinned regions are puncturable with a laser.

8. The intra-ocular pressure drain of claim 1, further comprising a one-way valve integral with the hollow tube to prevent a flow of discharge back into the eye.

9. The intra-ocular pressure drain of claim 8 wherein the one-way valve is normally-closed and positioned proximate to the open end, the drain further comprising a micromachined normally-open one-way valve integral with the hollow tube and positioned proximate to the closed end.

10. The intra-ocular pressure drain of claim 8 wherein the one-way valve is configured to open at a pressure of greater than between abut 12.0-18.1 mmHg.

11. The intro-ocular pressure drain of claim 8 wherein the one-way valve comprises a parylene diaphragm suspended by a tether.