Conversion of nitrogen dioxide (NO 2 ) to nitric oxide (NO)

• US 8,246,725 B2
• Filed: 10/07/2011
• Issued: 08/21/2012
• Est. Priority Date: 08/18/2004
• Status: Active Grant

• Current Assignee: Vero Biotech LLC
• Original Assignee: GENO LLC
• Inventors: Rounbehler, David R., Fine, David H.
• Primary Examiner(s): BHAT, NINA NMN
• Application Number:
  US13/269,106
• Publication Number:
  US 20120085457A1
• Time in Patent Office: 319 Days
• Field of Search: 422/120, 422/122, 951/02, 951/05, 951/20, 951/28, 951/29, 952/85, 128/200.14, 128/203.12, 961/54, 961/53, 141/18
• US Class Current: 95/285
• CPC Class Codes: A61M 15/00 Inhalators drug delivery in endotracheal tubes A61M16/04
• CPC Class Codes: A61M 16/10 Preparation of respiratory gases or vapours
• CPC Class Codes: A61M 16/122 with dilution
• CPC Class Codes: A61M 2016/1025 the O2 concentration
• CPC Class Codes: A61M 2202/0275 Nitric oxide [NO]
• CPC Class Codes: C01B 21/24 Nitric oxide (NO) C01B21/203 takes precedence

Abstract

A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

Claims

1. A method for making a device for converting nitrogen dioxide to nitric oxide comprising:

coating a surface-active material with a reducing agent to form a composition; and

filling at least a chamber of a conversion cartridge with the composition, wherein the conversion cartridge includes an inlet, the chamber and an outlet.

2. The method of claim 1, wherein the reducing agent is an antioxidant.

3. The method of claim 1, wherein the surface-active material comprises a substrate that retains water.

4. The method of claim 2, wherein the antioxidant comprises ascorbic acid, alpha tocopherol or gamma tocopherol.

5. The method of claim 1, wherein filling at least a portion of the receptacle includes filling the chamber.

6. The method of claim 5, wherein the method further includes coating a second surface-active material with a second reducing agent to form a second composition and filling the inlet or the outlet with the second composition.

7. The method of claim 6, wherein the first reducing agent and the second reducing agent are both antioxidants.

8. The method of claim 6, wherein the first reducing agent and the second reducing agent are the same reducing agent.

9. The method of claim 1, wherein filling at least a portion of the receptacle with the composition includes packing at least a portion of the receptacle with the composition.

10. The method of claim 1, wherein coating a surface-active material with a reducing agent to form a composition includes soaking the surface-active material in a solution including the reducing agent.

11. The method of claim 10, wherein coating a surface-active material with a reducing agent to form a composition further includes drying the surface-active material soaked with a solution including the reducing agent.