Self-assembled, micropatterned, and radio frequency (RF) shielded biocontainers and their uses for remote spatially controlled chemical delivery

• US 8,246,917 B2
• Filed: 06/25/2007
• Issued: 08/21/2012
• Est. Priority Date: 06/23/2006
• Status: Active Grant

• Current Assignee: Johns Hopkins University
• Original Assignee: Johns Hopkins University
• Inventors: Gracias, David H., Leong, Timothy Gar-Ming, Ye, Hongke
• Primary Examiner(s): Sines, Brian J
• Application Number:
  US12/306,423
• Publication Number:
  US 20090311190A1
• Time in Patent Office: 1,884 Days
• Field of Search: 422/547, 438/669, 977/700, 977/902, 977/904, 977/905, 977/906, 977/915
• US Class Current: 422/547
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/062 using magnetic field
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61K 49/1821 coated or functionalised microparticles or nanoparticles
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: A61K 9/5115 Inorganic compounds
• CPC Class Codes: A61K 9/5138 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/5192 Processes
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: G01R 33/286 involving passive visualization of interventional instruments, i.e. making the instrument visible as part of the normal MR process
• CPC Class Codes: Y10S 977/70 Nanostructure
• CPC Class Codes: Y10S 977/902 Specified use of nanostructure
• CPC Class Codes: Y10S 977/904 for medical, immunological, body treatment, or diagnosis
• CPC Class Codes: Y10S 977/905 Specially adapted for travel through blood circulatory system
• CPC Class Codes: Y10S 977/906 Drug delivery
• CPC Class Codes: Y10T 428/13 Hollow or container type article [e.g., tube, vase, etc.]
• CPC Class Codes: Y10T 428/1352 Polymer or resin containing [i.e., natural or synthetic]
• CPC Class Codes: Y10T 436/144444 Glucose
• CPC Class Codes: Y10T 436/25 : including sample preparation

Abstract

The present invention relates to a nanoscale or microscale particle for encapsulation and delivery of materials or substances, including, but not limited to, cells, drugs, tissue, gels and polymers contained within the particle, with subsequent release of the therapeutic materials in situ, methods of fabricating the particle by folding a 2D precursor into the 3D particle, and the use of the particle in in-vivo or in-vitro applications The particle can be in any polyhedral shape and its surfaces can have either no perforations or nano/microscale perforations The particle is coated with a biocompatible metal, e g gold, or polymer e g parvlene, layer and the surfaces and hinges of the particle are made of any metal or polymer combinations.

Claims

1. A three-dimensional particle comprising a plurality of two-dimensional faces capable of self-folding to form a hollow interior, wherein a size of the particle is microscale or nanoscale, and wherein the plurality of two-dimensional faces comprise a folding hinge between two adjacent faces and a locking hinge on an edge of a two-dimensional face, wherein the folding hinge between two adjacent faces has a width that is about twice a width of the locking hinge on an edge, wherein the plurality of two-dimensional faces comprising the three-dimensional particle are permanently held together by solid hinges, and wherein the particle further comprises at least one of (i) an active electronic or semiconductor component;

and (ii) at least one substance encapsulated within the particle.

2. The particle of claim 1, wherein the hinge comprises any liquefiable material.

3. The particle of claim 2, wherein the hinge is selected from the group consisting of a polymer, a gel, glass or a metal.

4. The particle of claim 1, wherein the particle has surfaces forming a polyhedral shape.

5. The particle of claim 4, wherein the shape is a cube.

6. The particle according to claim 1, wherein the two-dimensional faces are patterned with perforations or pores.

7. The particle according to claim 6, wherein the perforations or pores are created photolithographically, electrolytically, or by using electron beam lithography.

8. The particle according to claim 6, wherein the perforations or pores have a size from about 0.1 nm to about 1 cm.

9. The particle of claim 8, wherein the perforations or pores have a size from about 10 nm to about 1 cm.

10. The particle according to claim 1, wherein the particle is fabricated from at least one material selected from the group consisting of a metal, a polymer, a glass, a semiconductor, an insulator, and combinations thereof.

11. The particle according to claim 1, wherein the active electronic or semiconductor component is selected from the group consisting of transistors, sensors, actuators, light emitting diodes, photodiodes and solar cells.

12. The particle according to claim 10, wherein the metal is copper or nickel.

13. The particle according to claim 1, wherein the particle is a Faraday cage.

14. The particle according to claim 1, wherein the particle is coated with a biocompatible material.

15. The particle according, to claim 14, wherein the particle is associated with a biosensor.

16. The particle according to claim 14, wherein the biocompatible material is a metal, a polymer, or a combination thereof.

17. The particle according to claim 1, wherein the particle further comprises perforations or pores in the two-dimensional faces of the particle to allow release of the at least one substance encapsulated within the particle.

18. The particle of claim 1, wherein the substance is a therapeutic agent.

19. The particle according to claim 18, wherein the therapeutic agent is selected from the group consisting of a cell, a chemical or biological agent, a pharmaceutical agent, a composition, a tissue, a gel, and a polymer.

20. The particle according to claim 1, wherein the particle is administered to a subject and location of the particle in the subject is non-invasively tracked by magnetic resonance imaging (MRI) or CAT scan (CT).

21. The particle according to claim 20, wherein the particle is imaged with negative contrast relative to background or positive contrast relative to background.

22. The particle of claim 18, additionally comprising a radio frequency tag.

23. The particle of claim 22, wherein the substance may be released upon the particle'"'"'s exposure to a pre-selected frequency.

24. The particle of claim 22, wherein the substance may be released upon the particle'"'"'s exposure to electromagnetic radiation.

25. The particle of claim 24, wherein the electromagnetic radiation is triggered remotely.

26. The particle of claim 24, wherein the electromagnetic radiation ranges from 1 KHz to 1 Peta Hz.

27. The particle of claim 18, wherein the substance may be released upon the particle'"'"'s exposure to inductive heating.

28. The particle of claim 27, wherein the inductive heating is triggered remotely.

29. The particle of claim 1, wherein the size of the particle ranges from 1 nm to 2 nm.