Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells
First Claim
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1. A stable aqueous suspension of nanotube complexes suitable for delivery of a nanotube complex in said suspension to a living cell, said complex comprising:
- (a) an individual carbon nanotube; and
(b) a biologically active molecule, wherein said biologically active molecule comprises a polynucleic acid or a polypeptide bound to a linking agent which is noncovalently bound to the carbon nanotube, whereby the complex may be disassociated to release the biologically active molecule in active form inside a cell; and
further comprising(c) said linking agent comprising (i) a hydrophilic polymer and (ii) a hydrophobic polymer linked to the hydrophilic polymer, said hydrophilic polymer being covalently bound to the biologically active molecule.
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Abstract
Methods and materials for delivering biologically active molecules to cells in vitro or in vivo are provided. The methods and materials use carbon nanotubes or other hydrophobic particles, tubes and wires, functionalized with a linking group that is covalently bound to the nanotubes, or, alternatively, to the biologically active molecule, such as a protein. The biologically active molecule is preferably released from the nanotube when the complex has been taken up in an endosome.
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Citations
15 Claims
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1. A stable aqueous suspension of nanotube complexes suitable for delivery of a nanotube complex in said suspension to a living cell, said complex comprising:
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(a) an individual carbon nanotube; and (b) a biologically active molecule, wherein said biologically active molecule comprises a polynucleic acid or a polypeptide bound to a linking agent which is noncovalently bound to the carbon nanotube, whereby the complex may be disassociated to release the biologically active molecule in active form inside a cell; and
further comprising(c) said linking agent comprising (i) a hydrophilic polymer and (ii) a hydrophobic polymer linked to the hydrophilic polymer, said hydrophilic polymer being covalently bound to the biologically active molecule. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification