Digestive/laxative compositions

• US 8,247,008 B2
• Filed: 09/25/2011
• Issued: 08/21/2012
• Est. Priority Date: 03/21/2000
• Status: Expired due to Term

• Current Assignee: Mundipharma Singapore Holding Pte. Limited
• Original Assignee: Vital Food Processors Ltd. (Mundipharma International Limited)
• Inventors: Donaldson, Bruce William
• Primary Examiner(s): Vivlemore, Tracy
• Assistant Examiner(s): BERRIOS, JENNIFER A
• Application Number:
  US13/244,518
• Publication Number:
  US 20120076768A1
• Time in Patent Office: 331 Days
• Field of Search: None
• US Class Current: 424/777
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 38/4873 Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 1/10 Laxatives
• CPC Class Codes: A61P 1/12 Antidiarrhoeals
• CPC Class Codes: A61P 1/14 Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents

Abstract

Described are digestive/laxative compositions and methods of manufacture and use of same. In a preferred embodiment, the invention provides for a digestive/laxative composition including actinidin. The actinidin is preferably contributed by inclusion of fruit of genus actinidia, or a product thereof. Preferably, the process for forming the composition includes a method in which the fruit is processed at a temperature below that causing significant degradation of actinidin present, this temperature being preferably in the range of −40° C. to 40° C. Methods of administration of the composition are also described.

Claims

1. A composition comprising about 1 to 30% by weight of actinidin together with processed pulp that has been recovered from fruit of the genus Actinidia, wherein the composition is in an ingestible form chosen from powders, capsules, tablets, yogurts, ice creams, and combinations thereof.

2. A composition of claim 1, wherein the proportion of actinidin in the resulting composition is about 5% to 30% by weight.

3. A composition of claim 1, wherein the proportion of actinidin in the resulting composition is about 10% to 20% by weight.

4. A composition of claim 1, wherein the composition comprises milled freeze dried processed pulp recovered from the genus Actinidia.

5. A composition of claim 1, wherein the ingestible form is a powder.

6. A composition of claim 1, further comprising one or more ingredients chosen from carriers, tabletting aids, flavouring agents, texture improving agents, and product improving additives.

7. A composition of claim 1, wherein said actinidin together with processed pulp that has been recovered from fruit of the genus Actinidia is obtained by processing said fruit at a temperature in the range of −

10°

C. to 10°

C. to prevent significant degradation of actinidin.

8. A method for making a composition, comprising

(a) pulping fruit of the genus Actinidia to produce a pulped material,

(b) clarifying the pulped material to produce a clarified pulped material, and

(c) freeze drying the clarified pulped material, and

wherein the steps (a) to (c) of said method are performed at a temperature of about minus 10°

C. to plus 10°

C., such that substantial degradation of actinidin is prevented, and

wherein the composition comprises about 1 to 30% by weight of actinidin together with processed pulp that has been recovered from fruit of the genus Actinidia, wherein the composition is in an ingestible form chosen from powders, capsules, tablets, yogurts, ice creams, and combinations thereof.

19. A method of claim 8, wherein the ingestible form is a powder.

9. A method of treating a digestive or laxative dysfunction, comprising administering to a patient in need thereof an effective amount of a composition for a period of time sufficient to the digestive or laxative dysfunction, wherein the composition comprises about 1 to 30% by weight of actinidin together with processed pulp that has been recovered from fruit of the genus Actinidia, wherein the composition is in an ingestible form chosen from powders, capsules, tablets, yogurts, ice creams, and combinations thereof.

10. A method of claim 9, wherein the proportion of actinidin in the resulting composition is about 5% to 30% by weight.

11. A method of claim 9, wherein the proportion of actinidin in the resulting composition is about 10% to 20% by weight.

12. A method of claim 9, wherein the composition comprises milled freeze dried processed pulp recovered from the genus Actinidia.

13. A method of claim 9, wherein the ingestible form is a powder.

14. A method of claim 9, wherein about 10 to 250 mg of actinidin is administered per day.

15. A method of claim 9, wherein the digestive or laxative dysfunction is chosen from indigestion, gastric reflux, bloat, gas, abdominal pain, diarrhea, heart-burn, constipation, acid reflux, and irritable bowel syndrome.

16. A method of claim 9, wherein the digestive or laxative dysfunction is constipation.

17. A method of claim 9, wherein the digestive or laxative dysfunction is acid reflux.

18. A method of claim 9, wherein the digestive or laxative dysfunction is irritable bowel syndrome.