Blood glucose measuring device and method of measuring average postprandial blood glucose

• US 8,251,905 B2
• Filed: 03/17/2009
• Issued: 08/28/2012
• Est. Priority Date: 05/22/2008
• Status: Expired due to Fees

• Current Assignee: Tanita Corporation (Tanita)
• Original Assignee: Tanita Corporation (Tanita)
• Inventors: Miyashita, Mariko
• Primary Examiner(s): Natnithithadha, Navin
• Assistant Examiner(s): Reddy, Sunita
• Application Number:
  US12/405,653
• Publication Number:
  US 20090292190A1
• Time in Patent Office: 1,260 Days
• Field of Search: 600/365, 702/19, 422/52, 422/400, 422/402, 422 8201- 8209, 422/50, 205/777.5, 205/778, 205/792, 20440301-4031
• US Class Current: 600/365
• CPC Class Codes: A61B 5/14507 specially adapted for measuring characteristics of body fluids other than blood devices for taking samples of body liquids A61B10/0045
• CPC Class Codes: A61B 5/201 Assessing renal or kidney functions
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose

Abstract

A practical measuring device and a measuring method that allow simply measuring average postprandial blood glucose from urinary glucose. The blood glucose measuring device includes a measuring unit that measures postprandial urinary glucose from subject'"'"'s urine at a predetermined time after meal, a processing unit that calculates average postprandial blood glucose through a period up to the predetermined time after meal, based on the postprandial urinary glucose, a storage unit that stores calibration data including the postprandial urinary glucose and the average postprandial blood glucose in association, and an output unit that outputs data indicating the calculated average postprandial blood glucose. The processing unit calculates the average postprandial blood glucose, based on the postprandial urinary glucose from the urine of the subject who has intaken a desired amount of water or perspired in the period up to the predetermined time after meal, and the calibration data.

Claims

1. A blood glucose measuring device, comprising:

a storing unit that stores calibration data indicating a correlation between a postprandial urinary glucose at a predetermined time after meal and a time-averaged postprandial blood glucose through a period up to said predetermined time after meal;

a measuring unit that measures postprandial urinary glucose from urine of a subject at said predetermined time after meal;

a processing unit that calculates said time-averaged postprandial blood glucose, based on said postprandial urinary glucose measured; and

an output unit that outputs data indicating said postprandial blood glucose calculated,

wherein said correlation between said postprandial urinary glucose and said time-averaged postprandial blood glucose is maintained in a case where water intake or excretion takes place in said subject through drinking water or perspiration.

2. The blood glucose measuring device according to claim 1,

wherein said measuring unit accepts said urine of said subject who has intaken water or perspired in said period up to said predetermined time after meal, to thereby measure said postprandial urinary glucose.

3. The blood glucose measuring device according to claim 2,

wherein said processing unit calculates said time-averaged postprandial blood glucose based on said postprandial urinary glucose measured from said urine of said subject who has intaken water or perspired in said period up to said predetermined time after meal, and said postprandial urinary glucose measured from said urine of said subject who has neither intaken water nor perspired in said period up to said predetermined time after meal, utilizing said calibration data in common.

4. The blood glucose measuring device according to claim 1, further comprising an input unit that accepts an input of ratio information indicating a level of a conversion ratio from said postprandial urinary glucose to said time-averaged postprandial blood glucose of said subject;

wherein said processing unit calculates said time-averaged postprandial blood glucose based on said postprandial urinary glucose measured, and said ratio information.

5. The blood glucose measuring device according to claim 4,

wherein said input unit accepts an input of said ratio information selected from a first and a second of said conversion ratios, and

the time-averaged postprandial blood glucose calculated with respect to a given said postprandial urinary glucose by application of the first conversion ratio is lower than said time-averaged postprandial blood glucose calculated with respect to said given postprandial urinary glucose by application of the second conversion ratio.

6. The blood glucose measuring device according to claim 1, further comprising an input unit that accepts an input of at least one of sex information indicating a sex of said subject, blood information indicating hemoglobin A1c concentration of said subject, and ratio information indicating a level of a conversion ratio from said postprandial urinary glucose to said time-averaged postprandial blood glucose of said subject;

wherein said processing unit calculates said time-averaged postprandial blood glucose based on said postprandial urinary glucose measured, and at least one of said sex information, said blood information and said ratio information.

7. A method of measuring average postprandial blood glucose, comprising:

acquiring calibration data indicating a correlation between a postprandial urinary glucose at a predetermined time after meal and a time-averaged postprandial blood glucose through a period up to said predetermined time after meal, from a plurality of sample providers;

measuring said postprandial urinary glucose from urine of a subject at said predetermined time after meal; and

estimating, using a processing unit, said time-averaged postprandial blood glucose of said subject based on said postprandial urinary glucose measured and said calibration data,

wherein said correlation between said postprandial urinary glucose and said time-averaged postprandial blood glucose is maintained in a case where water intake or excretion takes place in said subject through drinking water or perspiration.

8. The method according to claim 7,

wherein said acquiring calibration data includes acquiring sample data from each of said sample providers indicating a correlation between an area of a region under a curve of a postprandial blood glucose but upper than a predetermined renal glucose excretion threshold and said postprandial urinary glucose, and statistically analyzing a plurality of said sample data acquired, to thereby calculate said calibration data.

9. The method according to claim 8,

wherein said calibration data calculated through statistical analysis forms a calibration line defined by an equation (1):

Time-averaged postprandial blood glucose=regression coefficient×

postprandial urinary glucose+threshold value 

 

(1).

10. The method according to claim 9,

wherein said renal glucose excretion threshold is adopted as said threshold value and said regression coefficient is specified as 2×

10<sup>−

2</sup>, in the case where said subject is a male and has a hemoglobin A1c concentration lower than 9.0%, and

said renal glucose excretion threshold is adopted as said threshold value and said regression coefficient is specified as 3×

10<sup>−

2</sup>, in the case where said subject is a female and has a hemoglobin A1c concentration lower than 7.5%.

11. The method according to claim 8, in which said acquiring calibration data includes classifying said sample data acquired from said sample providers into a plurality of groups, and calculating said calibration data based on said sample data of the respective groups, further comprising:

acquiring said sample data of said subject in advance;

wherein said estimating said time-averaged postprandial blood glucose includes identifying one of said groups to which said sample data acquired of said subject belongs, and estimating said time-averaged postprandial blood glucose of said subject based on said calibration data corresponding to said group identified and said postprandial urinary glucose measured.

12. The method according to claim 11,

wherein said sample providers and said subject include a male having a hemoglobin A1c concentration lower than 9.0%.

13. The method according to claim 7,

further comprising accepting said urine of said subject who has intaken water or perspired in said period up to said predetermined time after meal, and measuring said postprandial urinary glucose from said urine.

14. The method according to claim 13,

wherein said estimating said time-averaged postprandial blood glucose is based on

said postprandial urinary glucose measured from said urine of said subject who has intaken water or perspired in said period up to said predetermined time after meal, and

said postprandial urinary glucose measured from said urine of said subject who has neither intaken water nor perspired in said period up to said predetermined time after meal,

utilizing said calibration data in common.