Device for in vivo delivery of bioactive agents and method of manufacture thereof
First Claim
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1. An endoluminal stent for delivering a bioactive agent to a situs in a body, comprising:
- a plurality of vacuum deposited structural elements forming a radially expandable cylindrical member, the plurality of vacuum deposited structural elements including a complex finished geometry, each of the plurality of vacuum deposited structural elements having a wall thickness;
wherein the vacuum deposited structural elements are fabricated of a metal and comprise a base layer and a second layer covering the base layer, further comprising a void space intermediate the base and second layers that is enclosed therebetween;
a plurality of pores passing through the second layer and communicating with the void space such that the void space is open only through the plurality of pores; and
at least one bioactive agent retained within the void space and elutable through the plurality of pores.
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Abstract
The disclosure of the invention provides an implantable structural element for in vivo delivery of bioactive agents to a situs in a body. The implantable structural element may be configured as an implantable prosthesis, such as an endoluminal stent, cardiac valve, osteal implant or the like, which serves a dual function of being prosthetic and a carrier for a bioactive agent. Alternatively, the implantable structural element may simply be an implantable article that serves the single function of acting as a time-release carrier for the bioactive agent.
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13 Claims
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1. An endoluminal stent for delivering a bioactive agent to a situs in a body, comprising:
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a plurality of vacuum deposited structural elements forming a radially expandable cylindrical member, the plurality of vacuum deposited structural elements including a complex finished geometry, each of the plurality of vacuum deposited structural elements having a wall thickness;
wherein the vacuum deposited structural elements are fabricated of a metal and comprise a base layer and a second layer covering the base layer, further comprising a void space intermediate the base and second layers that is enclosed therebetween;a plurality of pores passing through the second layer and communicating with the void space such that the void space is open only through the plurality of pores; and at least one bioactive agent retained within the void space and elutable through the plurality of pores. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification