Drug delivery from electroactive molecularly imprinted polymer

• US 8,252,045 B2
• Filed: 03/10/2006
• Issued: 08/28/2012
• Est. Priority Date: 03/12/2005
• Status: Expired due to Fees

• Current Assignee: Saint Louis University
• Original Assignee: Saint Louis University
• Inventors: Minteer, Shelley, Ulyanova, Jenny
• Primary Examiner(s): Weber, Jon P
• Assistant Examiner(s): UNDERDAHL, THANE E
• Application Number:
  US11/372,653
• Publication Number:
  US 20070077461A1
• Time in Patent Office: 2,363 Days
• Field of Search: 623/1.42, 252/301.25, 424/78.22
• US Class Current: 623/1.42
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: H01M 8/16 Biochemical fuel cells, i.e. cells in which microorganisms function as catalysts
• CPC Class Codes: Y02E 60/50 Fuel cells

Abstract

A device delivers a chemical or biological agent, the device comprises an imprint molecule (IM) to be delivered by the device; an electroactive molecularly imprinted polymer (EMIP) imprinted with the imprint molecule, the EMIP having a plurality of binding sites capable of binding the imprint; and an electric potential producing member (EPM), the EPM being capable of producing an electric potential between the EPM and the EMIP; whereby when the EMIP has a predetermined density of imprint molecule bound at the binding sites, and whereby when a sufficient potential is produced between the EPM and the EMIP, the imprint molecule is released from the binding site and thereby delivered by the device.

Claims

1. A method of delivering a chemical or biological agent comprising:

providing a device for delivery of a chemical or biological agent comprising;

an electroactive imprinted polymer having a plurality of binding sites, each binding site being capable of existing in either a first electroconformation or a second electroconformation wherein said first electroconformation and said second electroconformation provide different physical conformations of said binding site;

a chemical or biological agent bound within at least one binding site in said plurality of binding sites; and

a means for creating an electric potential between said means for creating an electric potential and said electroactive imprinted polymer, said means being electrically connected to said electroactive imprinted polymer;

activating said means for creating an electric potential so as to generate said electric potential in said electroactive imprinted polymer;

said electric potential converting said at least one of said binding sites from said first electroconformation to said second electroconformation; and

releasing said chemical or biological agent from said binding site to which it is bound as a result of said converting altering the physical conformation of said binding site

wherein said electroactive imprinted polymer is of the class termed polyazine.

2. The method of claim 1 further comprising:

placing said device in an environment including an analyte of interest; and

sensing said analyte of interest with said means for creating electric potential;

wherein said means for creating electric potential is an analyte sensor that senses said analyte; and

wherein said step of activating is a result of said step of sensing.

3. The method of claim 2 wherein said step of sensing does not involve said analyte being either oxidized or reduced.

4. The method of claim 2 wherein said analyte is selected from the group consisting of a neurotransmitter, a hormone, a catecholamine, an autocrine factor, a paracrine factor, a fatty acid, an adrenocoritcal hormone, epinephrine, norepinephrine, serotonin, dopamine, glucose, nitric oxide, pyruvate, cholesterol, and linoleic acid.

5. The method of claim 1 wherein only a single molecule of said chemical or biological agent is encompassed by each of said binding sites in said plurality of binding sites.