Neural progenitor cell populations
First Claim
1. A first and second cell population comprising a) a first in vitro population of cells comprising human embryonic stem cells;
- and b) a second in vitro cell population comprising progeny of a portion of the first population of cells, wherein the progeny express NCAM.
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Abstract
This invention provides populations of neural progenitor cells, differentiated neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell populations (such as embryonic stem cells) in a cocktail of growth conditions that initiates differentiation, and establishes the neural progenitor population. The progenitors can be further differentiated in culture into a variety of different neural phenotypes, including dopaminergic neurons. The differentiated cell populations or the neural progenitors can be generated in large quantities for use in drug screening and the treatment of neurological disorders.
56 Citations
9 Claims
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1. A first and second cell population comprising a) a first in vitro population of cells comprising human embryonic stem cells;
- and b) a second in vitro cell population comprising progeny of a portion of the first population of cells, wherein the progeny express NCAM.
- View Dependent Claims (2)
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3. A first and second cell population comprising a) a first in vitro population of cells comprising human embryonic stem cells;
- and b) a second in vitro cell population comprising progeny of a portion of the first population of cells, wherein the progeny express A2B5.
- View Dependent Claims (4, 5, 6, 7, 8)
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9. A first and second cell population comprising a) a first in vitro population of cells comprising human embryonic stem cells;
- and b) a second in vitro cell population comprising progeny of a portion of the first population of cells, wherein the progeny express tyrosine hydroxylase and
wherein the second population of cells express Map-2.
- and b) a second in vitro cell population comprising progeny of a portion of the first population of cells, wherein the progeny express tyrosine hydroxylase and
Specification