Implantable pump for protein delivery for obesity control by drug infusion into the brain
First Claim
Patent Images
1. A drug delivery system comprising:
- an implantable drug infusion pump; and
a stable suspension of an effective dosage of an appetite suppressing agent, the appetite suppressing agent comprising a polypeptide having the general formula;
(Mp-Lk-V2-Hg—
CH2-CH3)(t)
(I)wherein Mp is an alpha melanocyte-stimulating hormone (α
-MSH) peptide, Lk is a polypeptide or chemical linkage, V2 is a portion of a C-terminus of an immunoglobulin variable region, Hg is at least a portion of an immunoglobulin variable hinge region, CH2 is an immunoglobulin heavy chain CH2 constant region, CH3 is an immunoglobulin heavy chain CH3 constant region, and t is an integer of 1 to 10,wherein the appetite suppressing agent binds to a melanocortin receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.
0 Assignments
0 Petitions
Accused Products
Abstract
Methods and compositions are provided for suppressing appetite by surgically implanting a drug infusion pump into a site in a subject, and delivering a stable suspension of an appetite suppressing agent a region in a central nervous system of the subject. The appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.
35 Citations
2 Claims
-
1. A drug delivery system comprising:
-
an implantable drug infusion pump; and a stable suspension of an effective dosage of an appetite suppressing agent, the appetite suppressing agent comprising a polypeptide having the general formula;
(Mp-Lk-V2-Hg—
CH2-CH3)(t)
(I)wherein Mp is an alpha melanocyte-stimulating hormone (α
-MSH) peptide, Lk is a polypeptide or chemical linkage, V2 is a portion of a C-terminus of an immunoglobulin variable region, Hg is at least a portion of an immunoglobulin variable hinge region, CH2 is an immunoglobulin heavy chain CH2 constant region, CH3 is an immunoglobulin heavy chain CH3 constant region, and t is an integer of 1 to 10,wherein the appetite suppressing agent binds to a melanocortin receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite. - View Dependent Claims (2)
-
Specification
-
- Resources
Litigation Campaign Assessment
Thank you for your request. You will receive a custom alert email when the Litigation Campaign Assessment is available.
×
-
Current AssigneeCodman & Shurtleff Incorporated (Johnson & Johnson)
-
Original AssigneeCodman & Shurtleff Incorporated (Johnson & Johnson)
-
InventorsStojanovic-Susulic, Vedrana, Venugopalan, Ramakrishna, Cunningham, Mark
-
Primary Examiner(s)Bunner, Bridget E
-
Assistant Examiner(s)BORGEEST, CHRISTINA M
-
Application NumberUS12/709,920Publication NumberTime in Patent Office918 DaysField of SearchNoneUS Class Current514/10.7CPC Class CodesA61K 38/34 Melanocyte stimulating horm...A61K 47/6811 the drug being a protein or...A61K 47/6849 the antibody targeting a re...A61P 1/00 Drugs for disorders of the ...A61P 3/04 Anorexiants; Antiobesity ag...
