Implantable pump for protein delivery for obesity control by drug infusion into the brain
First Claim
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1. A drug delivery system comprising:
- an implantable drug infusion pump; and
a stable suspension of an effective dosage of an appetite suppressing agent, the appetite suppressing agent comprising a polypeptide having the general formula;
(Mp-Lk-V2-Hg—
CH2-CH3)(t)
(I)wherein Mp is an alpha melanocyte-stimulating hormone (α
-MSH) peptide, Lk is a polypeptide or chemical linkage, V2 is a portion of a C-terminus of an immunoglobulin variable region, Hg is at least a portion of an immunoglobulin variable hinge region, CH2 is an immunoglobulin heavy chain CH2 constant region, CH3 is an immunoglobulin heavy chain CH3 constant region, and t is an integer of 1 to 10,wherein the appetite suppressing agent binds to a melanocortin receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.
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Abstract
Methods and compositions are provided for suppressing appetite by surgically implanting a drug infusion pump into a site in a subject, and delivering a stable suspension of an appetite suppressing agent a region in a central nervous system of the subject. The appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.
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Citations
2 Claims
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1. A drug delivery system comprising:
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an implantable drug infusion pump; and a stable suspension of an effective dosage of an appetite suppressing agent, the appetite suppressing agent comprising a polypeptide having the general formula;
(Mp-Lk-V2-Hg—
CH2-CH3)(t)
(I)wherein Mp is an alpha melanocyte-stimulating hormone (α
-MSH) peptide, Lk is a polypeptide or chemical linkage, V2 is a portion of a C-terminus of an immunoglobulin variable region, Hg is at least a portion of an immunoglobulin variable hinge region, CH2 is an immunoglobulin heavy chain CH2 constant region, CH3 is an immunoglobulin heavy chain CH3 constant region, and t is an integer of 1 to 10,wherein the appetite suppressing agent binds to a melanocortin receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite. - View Dependent Claims (2)
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Specification