Biomaterials and a method for making and using same

• US 8,252,771 B2
• Filed: 01/31/2008
• Issued: 08/28/2012
• Est. Priority Date: 01/31/2007
• Status: Expired due to Fees

• Current Assignee: Allergan Incorporated (Abbvie Incorporated)
• Original Assignee: Allergan Incorporated (Abbvie Incorporated)
• Inventors: Utecht, Ronald E., Kloster, Kaia L., Downey, Therese M., Haberer, Barbara R., Youso, Patrick D., Chang, James N.
• Primary Examiner(s): Jiang, Shaojia Anna
• Assistant Examiner(s): Henry, Michael C
• Application Number:
  US12/023,977
• Publication Number:
  US 20080207561A1
• Time in Patent Office: 1,671 Days
• Field of Search: 514/55, 514/23, 536/20, 536/124
• US Class Current: 514/55
• CPC Class Codes: A61K 31/407 condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
• CPC Class Codes: A61K 31/5575 having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
• CPC Class Codes: A61K 31/573 substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 47/61 the organic macromolecular compound being a polysaccharide or a derivative thereof
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 24/08 Polysaccharides A61L24/043 takes precedence
• CPC Class Codes: A61L 2430/16 for reconstruction of eye parts, e.g. intraocular lens, cornea
• CPC Class Codes: A61L 27/20 Polysaccharides
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: C08B 37/003 Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
• CPC Class Codes: C08L 5/08 Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Abstract

A biomaterial is disclosed having unique properties that make it useful in ocular drug delivery applications, where the drugs selected from the group consisting of a prostaglandin, a prostamide, a non-steroidal anti-inflammatory drug (NSAID), and a corticosteroid, and mixtures, derivatives, salts and esters thereof.

Claims

1. A method for treating glaucoma, the method comprising the step of:

administering to an eye of a patient a pharmaceutical composition comprising a modified chitosan and a therapeutic agent selected from the group consisting of a prostaglandin and a prostamide, thereby treating the glaucoma, wherein the modified chitosan is a chitosan that is covalently modified with an alkyl sulfonic acid, and wherein the therapeutic agent is covalently bonded to sites on the covalently modified chitosan via a linker.

2. The method of claim 1, wherein the alkyl sulfonic acid is octane sulfonic acid.

3. The method of claim 2, wherein the therapeutic agent is bimatoprost and the linker is succinic anhydride.