Oxygen enhancing membrane systems for implantable devices
First Claim
1. An implantable device for continuous in vivo measurement of an analyte concentration in a host, the device comprising:
- a sensor configured for implantation in a host, the sensor configured to operatively connect with electronic circuitry configured to generate a signal associated with a concentration of an analyte in a host; and
a membrane located over the sensor and configured to control a flux of oxygen and the analyte therethrough, wherein the membrane comprises a material having an oxygen permeability of from about 5 Barrers to about 1000 Barrers.
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Abstract
The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
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Citations
21 Claims
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1. An implantable device for continuous in vivo measurement of an analyte concentration in a host, the device comprising:
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a sensor configured for implantation in a host, the sensor configured to operatively connect with electronic circuitry configured to generate a signal associated with a concentration of an analyte in a host; and a membrane located over the sensor and configured to control a flux of oxygen and the analyte therethrough, wherein the membrane comprises a material having an oxygen permeability of from about 5 Barrers to about 1000 Barrers. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. An implantable device for continuous in vivo measurement of a glucose concentration in a host, the device comprising:
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a sensor operatively connected to electronic circuitry configured to generate a signal associated with a concentration of glucose in a host; and a membrane located over the sensor and configured to control a flux of oxygen and glucose therethrough, wherein the membrane comprises a material having an oxygen permeability of from about 5 Barrers to about 1000 Barrers, wherein the material comprises a copolymer comprising a fluorocarbon segment and a polycarbonate segment, wherein the membrane has a thickness of from about 3 microns to about 65 microns, and wherein the membrane comprises an enzyme domain comprising an enzyme configured to react with glucose. - View Dependent Claims (21)
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Specification