Breathing disorder and precursor predictor and therapy delivery device and method
First Claim
Patent Images
1. A device for treating a sleep breathing disorder comprising:
- at least one electrode configured to sense a parameter corresponding to a precursor to onset of a sleep breathing disorder where intrinsic breathing is present, and the at least one electrode, or an additional electrode, configured to deliver an electrical signal targeting diaphragm or phrenic nerve tissue to cause contraction of at least a portion of a diaphragm to control breathing in response to a sensed precursor, to prevent or mitigate a sleep breathing disorder in a subject;
a control unit comprising;
a stimulation pulse generator configured to deliver electrical stimulation to the tissue through the at least one electrode to thereby elicit a diaphragm response to control a breathing of the subject;
wherein the control unit is programmed to detect the precursor and to deliver the stimulation in response to information sensed by the at least one electrode by controlling electrical stimulation delivered to the tissue through the electrode,wherein the control unit is further programmed to control the stimulation pulse generator to deliver a burst or series of pulses as the electrical stimulation; and
wherein upon detecting a precursor to onset of a sleep breathing disorder, the control unit is further programmed to provide at least one electrical stimulation, monitor the breathing of the subject for a first interval of time and provide at least one electrical stimulation if the breathing is not as desired, monitor the breathing for at least a subsequent second interval of time longer than the first interval, sense for normalized breathing, compare the breathing to intrinsic breathing, and to further provide at least one electrical stimulation if the breathing is not as desired or cease the at least one electrical stimulation if breathing is as desired.
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Abstract
A device and method for sensing breathing disorders, irregularities or insufficiencies is provided. One aspect includes sensing a precursor to an onset of a breathing disorder or episode of a breathing disorder and responding to sensing the precursor. Another aspect includes responding to treat the breathing disorder before manifestation of the disorder. Another aspect includes identifying a likelihood of a breathing disorder and responding using the likelihood and other information indicating onset or occurrence of a breathing disorder.
224 Citations
51 Claims
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1. A device for treating a sleep breathing disorder comprising:
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at least one electrode configured to sense a parameter corresponding to a precursor to onset of a sleep breathing disorder where intrinsic breathing is present, and the at least one electrode, or an additional electrode, configured to deliver an electrical signal targeting diaphragm or phrenic nerve tissue to cause contraction of at least a portion of a diaphragm to control breathing in response to a sensed precursor, to prevent or mitigate a sleep breathing disorder in a subject; a control unit comprising; a stimulation pulse generator configured to deliver electrical stimulation to the tissue through the at least one electrode to thereby elicit a diaphragm response to control a breathing of the subject; wherein the control unit is programmed to detect the precursor and to deliver the stimulation in response to information sensed by the at least one electrode by controlling electrical stimulation delivered to the tissue through the electrode, wherein the control unit is further programmed to control the stimulation pulse generator to deliver a burst or series of pulses as the electrical stimulation; and wherein upon detecting a precursor to onset of a sleep breathing disorder, the control unit is further programmed to provide at least one electrical stimulation, monitor the breathing of the subject for a first interval of time and provide at least one electrical stimulation if the breathing is not as desired, monitor the breathing for at least a subsequent second interval of time longer than the first interval, sense for normalized breathing, compare the breathing to intrinsic breathing, and to further provide at least one electrical stimulation if the breathing is not as desired or cease the at least one electrical stimulation if breathing is as desired. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A system for treating a subject comprising:
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at least one electrode configured to sense at least one parameter corresponding to the at least one precursor to the onset of a sleep breathing disorder during a period; a control unit comprising; a) an analyzer coupled to the at least one electrode configured to sense respiration, wherein the analyzer is programmed to recognize a respiratory pattern where intrinsic breathing is present corresponding to a likelihood of a sleep breathing disorder occurring at a time after the period; and b) an electrical stimulator programmed to deliver electrical stimulation to at least one of said electrodes directly targeting a subject'"'"'s diaphragm or phrenic nerve to cause contraction of at least a portion of a diaphragm to control breathing prior to onset or to mitigate a breathing disorder in response to the analyzer recognizing the respiratory pattern corresponding to a likelihood of a breathing disorder occurring a time after the period, wherein the electrical stimulator is further programmed to deliver a burst or series of pulses as the electrical stimulation; and wherein upon sensing of a precursor to the onset of a sleep breathing disorder, the control unit is further programmed to provide at least one electrical stimulation, monitor the breathing of the subject for a first interval of time and provide at least one electrical stimulation if the breathing is not as desired, monitor the breathing for at least a subsequent second longer interval of time, sense for normalized breathing, and to further provide at least one electrical stimulation if the breathing is not as desired or cease the at least one electrical stimulation if the breathing is as desired.
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19. A method for treating a sleep breathing disorder in a subject having intrinsic breathing, comprising the steps of:
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sensing a precursor to a breathing disorder in the subject where intrinsic breathing is present; evaluating the sensed precursor via an analyzer which is programmed to recognize a respiratory pattern corresponding to a sleep breathing disorder; and
,if the analyzer recognizes the respiratory pattern corresponding to the sleep breathing disorder, delivering an electrical stimulation signal comprising a burst or series of pulses through an electrode to diaphragm or phrenic nerve tissue to contract at least a portion of a diaphragm in response to the sensed precursor thereby preventing an onset or mitigating the sleep breathing disorder; monitoring the breathing of the subject for a first interval of time and providing at least one electrical stimulation if the breathing is not as desired, monitoring the breathing for at least a subsequent second interval of time longer than the first interval, sensing for normalized breathing, and providing at least one electrical stimulation signal if the breathing is not as desired or ceasing the at least one electrical stimulation if the breathing is as desired. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. A device for treating a breathing disorder comprising:
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at least one electrode configured to sense a parameter corresponding to a precursor to onset of a breathing disorder in a subject having intrinsic breathing, and to deliver an electrical signal directly targeting diaphragm or phrenic nerve tissue to cause contraction of at least a portion of a diaphragm to control breathing in response to a sensed precursor, to prevent or mitigate a breathing disorder in the subject; and
,a control unit programmed to deliver electrical stimulation to the tissue through the at least one electrode to thereby elicit a diaphragm response to control a breathing of the subject; an analyzer being programmed to detect the precursor and to respond to information sensed by the at least one electrode by delivering a burst or series of pulses as the electrical stimulation to the tissue through the electrode; and wherein upon sensing of a precursor to onset of a sleep breathing disorder, the device is further programmed to provide at least one electrical stimulation, monitor the breathing of the subject for a first interval of time and provide at least one electrical stimulation if the breathing is not as desired, monitor the breathing for at least a subsequent second interval of time longer than the first interval, sense for normalized breathing, and to further provide at least one electrical stimulation if the breathing is not as desired or cease the at least one electrical stimulation if the breathing is as desired. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
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Specification