Blood flow bypass catheters and methods for the delivery of medium to the vasculature and body ducts
First Claim
1. A method for generating a configuration of elements of a catheter device, said catheter device comprising passages for blood flow and medium flow and inlet and exit ports for blood flow and medium flow, said method comprising:
- selecting variables including;
a) geometrical shapes and dimensions of said blood passages and said medium passages,b) relative locations and orientations of flow planes of at least some of said inlet ports and exit ports; and
c) concentration and residence time of medium in the vicinity of a specific location outside said catheter device; and
applying a global optimization algorithm using a computer to the variables to generate a catheter with optimized flow conditions,wherein, a position of said inlet ports and said exit ports is determined by application of the global optimization algorithm.
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Abstract
A catheterization device that may be designed by use of an adaptive genetic algorithm computational fluid dynamics approach, as well as other Global Optimization methods that may include simulated annealing, multistart and interval methods, continuous branch and bound methods, evolutionary algorithms, and tabu search and scatter search methods, as well as other available Global Optimization methods that is able to maximize/optimize the dwell time of an infused agent in the vicinity of a vascular lesion. The device may have an internal by-pass channel that allows the blood upstream of the lesion to continue its pulsatile flow through the vessel in the part of it occluded by the lesion, while simultaneously allowing the disbursement and maximal dwell time of an antithrombolytic or other diagnostic or therapeutic agent needed to treat the lesion. Different embodiments of the catheterization device are disclosed and indications for the use of these devices in the treatment of vascular diseases are discussed.
70 Citations
17 Claims
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1. A method for generating a configuration of elements of a catheter device, said catheter device comprising passages for blood flow and medium flow and inlet and exit ports for blood flow and medium flow, said method comprising:
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selecting variables including; a) geometrical shapes and dimensions of said blood passages and said medium passages, b) relative locations and orientations of flow planes of at least some of said inlet ports and exit ports; and c) concentration and residence time of medium in the vicinity of a specific location outside said catheter device; and applying a global optimization algorithm using a computer to the variables to generate a catheter with optimized flow conditions, wherein, a position of said inlet ports and said exit ports is determined by application of the global optimization algorithm. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A computer program product comprising a non-transitory computer useable storage medium having computer program logic for enabling at least one processor in a computer system to generate a configuration of elements on a catheter device, said catheter device comprising passages for blood flow and medium flow and inlet and exit ports for blood flow and medium flow, said computer program logic comprising:
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selecting variables-including; a) geometrical shapes and dimensions of at least some of said blood passages and said medium passages, b) relative locations and orientations of flow planes of at least some of said inlet ports and exit ports; and c) concentration and residence time of medium in the vicinity of a specific location outside said catheter device; and applying a global optimization algorithm to the variables to generate a catheter with optimized flow conditions, wherein, a position of said inlet ports and said exit ports is determined by application of the global optimization algorithm. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
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Specification