Bioimpedance methods and apparatus

• US 8,257,280 B2
• Filed: 05/13/2011
• Issued: 09/04/2012
• Est. Priority Date: 09/12/2003
• Status: Active Grant

• Current Assignee: Renal Research Institute LLC
• Original Assignee: Renal Research Institute LLC
• Inventors: Levin, Nathan W., Zhu, Fansan
• Primary Examiner(s): Hindenburg, Max
• Assistant Examiner(s): HENSON, DEVIN B
• Application Number:
  US13/107,246
• Publication Number:
  US 20110275922A1
• Time in Patent Office: 480 Days
• Field of Search: 600/306, 600/372, 600/382, 600/388, 600/389, 600/390, 600/393, 600/547, 600/587, 735/12, 737/55, 737/59
• US Class Current: 600/587
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/4872 Body fat
• CPC Class Codes: A61B 5/4881 Determining interstitial fluid distribution or content within body tissue measuring analytes in interstitial fluid in-vivo A61B5/1451

Abstract

Methods and apparatus for providing bioimpedance analysis are provided. In certain aspects, equivalent circuit frequency response models are provided which lead to improved correlations with MRI data. The frequency response models take account of body composition, including the fat component of a body segment. Data obtained by performing bioimpedance spectroscopy (BIS) and MRI on the calves of subjects illustrates the improved correlations achieved compared to single frequency analyses at 50 kilohertz and analyses performed using the conventional Cole-Cole model.

Claims

1. A method for determining the circumference of a portion of a body segment covered by skin comprising:

(a) applying a series of electrodes around said portion, said series of electrodes having a first electrode and a last electrode, the circumferential distances between all electrodes in the series being known, except for the distance between the first and last electrodes;

(b) determining the resistance between at least two electrodes of the series, other than the first and last electrode, by applying a low frequency current which does not substantially penetrate the skin;

(c) determining a resistivity value per unit length for the skin from the resistance determined in step (b) and the known circumferential distance between the two electrodes;

(d) determining the resistance between the first and last electrodes of the series by applying a low frequency current which does not substantially penetrate the skin; and

(e) calculating the distance between the first and last electrodes of the series from the resistance measured in step (d) and the resistivity value per unit length determined in step (c).

2. The method of claim 1 wherein the resistances between all adjacent pairs of electrodes, other than the first and last electrodes, are determined in step (b) and used in step (c) to determine the resistivity value.

3. The method of claim 1 wherein, except for the first and last electrodes, the distances between adjacent pairs of electrodes are equal.

4. The method of claim 1 wherein the series of electrodes are carried by a belt.

5. Apparatus comprising a programmed computer for determining the circumference of a portion of a body segment covered by skin, said apparatus being adapted for use with a series of electrodes for application around said portion of a body segment, said series of electrodes having a first electrode and a last electrode, the circumferential distances between all electrodes in the series being known, except for the distance between the first and last electrodes, said programmed computer comprising a non-transitory computer readable storage medium having computer executable code embodied therein for performing the steps of:

(i) determining the resistance between at least two electrodes of the series of electrodes, other than the first and last electrode, by applying a low frequency current which does not substantially penetrate the skin;

(ii) determining a resistivity value per unit length for the skin from the resistance determined in step (i) and the known circumferential distance between the two electrodes;

(iii) determining the resistance between the first and last electrodes of the series by applying a low frequency current which does not substantially penetrate the skin; and

(iv) calculating the distance between the first and last electrodes of the series from the resistance determined in step (iii) and the resistivity value per unit length determined in step (ii).