Spinal fixation with selectively applied bone growth promoting agent

• US 8,257,395 B2
• Filed: 09/21/2007
• Issued: 09/04/2012
• Est. Priority Date: 09/21/2007
• Status: Active Grant

• Current Assignee: Jmea Corporation
• Original Assignee: Jmea Corporation
• Inventors: Bhatnagar, Mohit K., Yeh, Jack Y.
• Primary Examiner(s): Robert, Eduardo C
• Assistant Examiner(s): Cumberledge, Jerry
• Application Number:
  US11/859,386
• Publication Number:
  US 20090082810A1
• Time in Patent Office: 1,810 Days
• Field of Search: 606/60, 606/246, 606250-279
• US Class Current: 606/246
• CPC Class Codes: A61B 17/7002 Longitudinal elements, e.g. rods
• CPC Class Codes: A61B 17/701 Longitudinal elements with a non-circular, e.g. rectangular, cross-section A61B17/7005, A61B17/7007 take precedence
• CPC Class Codes: A61B 17/7044 also having plates, staples or washers bearing on the vertebrae
• CPC Class Codes: A61B 17/7055 connected to sacrum, pelvis or skull
• CPC Class Codes: A61B 17/7059 Cortical plates A61B17/7007, A61B17/7058 take precedence
• CPC Class Codes: A61B 17/7064 Devices acting on, attached to, or simulating the effect of, vertebral facets; Tools therefor
• CPC Class Codes: A61B 17/7071 Implants for expanding or repairing the vertebral arch or wedged between laminae or pedicles; Tools therefor
• CPC Class Codes: A61B 17/7208 Flexible pins, e.g. ENDER pins
• CPC Class Codes: A61B 17/7233 with special means of locking the nail to the bone
• CPC Class Codes: A61B 17/7266 with fingers moving radially outwardly
• CPC Class Codes: A61B 17/80 Cortical plates , i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
• CPC Class Codes: A61B 17/864 hollow, e.g. with socket or cannulated
• CPC Class Codes: A61B 17/866 Material or manufacture
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2002/0081 directly machined on the prosthetic surface, e.g. holes, grooves A61F2/30771 takes precedence

Abstract

A spinal fixation system including a selectively applied bone growth promoting agent is disclosed. The types of spinal fixation systems which may include a selectively applied bone growth promoting agent include systems comprised of rods, plates, screws, and hooks as well as other types of prostheses.

Claims

1. A spinal fixation system, comprising:

a screw configured for implantation into at least one vertebral body;

the screw including a screw body;

a rod that is coupled to the screw using a coupling device;

wherein the rod includes a first portion within the coupling device and a second exposed portion outside the coupling device, and wherein the second exposed portion of the rod includes a first region and a second region;

wherein the first region of the second exposed portion of the rod is a first radial section of the rod and wherein the second region of the second exposed portion of the rod is a second remaining radial section of the rod;

wherein the first radial section is limited to a portion of the rod that is visible when viewing the rod from a direction in which the screw extends from the rod;

wherein the first region of the rod has bone growth promoting agent and the second region remains exposed without bone growth promoting agent;

wherein the first region includes a first area having a bone growth promoting agent selectively applied in a first pattern and a second area having a bone growth promoting agent selectively applied in a second pattern; and

wherein the first pattern is different from the second pattern.

2. The spinal fixation system according to claim 1, wherein the rod is associated with two or more screws, each screw including a screw body with a bone growth promoting agent selectively applied to the screw body.

3. The spinal fixation system according to claim 1, wherein the bone growth promoting agent is applied to the screw and the coupling device, and wherein the bone growth promoting agent extends from the first region of the rod, through the coupling device, and to the screw.

4. The spinal fixation system according to claim 1, wherein the first pattern comprises a striped pattern and the second pattern comprises a spotted pattern.

5. The spinal fixation system according to claim 1, wherein the rod is associated with multiple hooks and multiple connecting devices for fixing the hooks to the rod, and wherein the multiple hooks include a selectively applied bone growth promoting agent.

6. The bone fixation system according to claim 1, wherein the first pattern comprises a striped pattern and the second pattern comprises a striped pattern different from the striped pattern of the first pattern.

7. The spinal fixation system according to claim 1, wherein the bone growth promoting agent is applied to the first area in a spotted pattern comprising a plurality of spaced apart spots.

8. The spinal fixation system according to claim 7, wherein the spaced apart spots vary in shape.

9. The spinal fixation system according to claim 1, wherein the first radial section and the second radial section are approximately equal.

10. The spinal fixation system according to claim 1, wherein when the spinal fixation system is implanted in the at least one vertebral body, the first region of the second exposed portion of the rod is associated with an anterior side of the at least one vertebral body and the second region of the second exposed portion of the rod is associated with a posterior side of the at least one vertebral body.

11. The spinal fixation system according to claim 1, wherein the first area and the second area are longitudinally spaced apart.

12. The spinal fixation system according to claim 1, wherein the bone growth promoting agent is applied to the first area in a geometric pattern comprising a checkerboard.

13. The spinal fixation system according to claim 1, wherein the bone growth promoting agent of the first area is different from the bone growth promoting agent of the second area.

14. A spinal fixation system, comprising:

a first screw configured for implantation into a first vertebral body and a second screw configured for implantation into a second vertebral body;

the first screw and the second screw each including a first screw body and a second screw body;

a rod that is coupled to the first screw and the second screw using a first coupling device and a second coupling device,

wherein the rod includes a first portion within the first coupling device, a second portion within the second coupling device, and a third exposed portion between the first and second coupling devices, and wherein the third exposed portion of the rod includes a first region and a second region;

wherein a bone growth promoting agent is applied to the first and second screw bodies,

wherein the first region of the third exposed portion of the rod is a first radial section of the rod and wherein the second region of the third exposed portion of the rod is a second remaining radial section of the rod;

wherein the first radial section is limited to a portion of the rod that is visible when viewing the rod from a direction in which the screw extends from the rod;

wherein the first region of the rod has bone growth promoting agent and the second region remains exposed without bone growth promoting agent;

wherein the first region includes a first area having a bone growth promoting agent selectively applied in a first pattern and a second area having a bone growth promoting agent selectively applied in a second pattern; and

wherein the first pattern is different from the second pattern.

15. The spinal fixation system according to claim 14, wherein the first screw is associated with a first screw set that is configured for implantation into the second vertebral body.

16. The spinal fixation system according to claim 15, wherein the screws comprising the first screw set include screw bodies with a selectively applied bone growth promoting agent.

17. The spinal fixation system according to claim 14, wherein the second screw is associated with a second screw set that is configured for implantation into the first vertebral body.

18. The spinal fixation system according to claim 17, wherein the screws comprising the second screw set include screw bodies with a selectively applied bone growth promoting agent.

19. The spinal fixation system according to claim 14, wherein the bone growth promoting agent is applied to the first screw, the second screw, the first coupling device, and the second coupling device, and wherein the bone growth promoting agent extends from the first screw, through the first coupling device, through the first region of the rod, through the second coupling device, and to the second screw.

20. The spinal fixation system according to claim 14, wherein the first coupling device and the second coupling device include a bone growth promoting agent.

21. The spinal fixation system according to claim 14, wherein the first pattern comprises a striped pattern and the second pattern comprises a spotted pattern.

22. The spinal fixation system according to claim 14, wherein the first pattern comprises a striped pattern and the second pattern comprises a striped pattern different from the striped pattern of the first pattern.

23. The spinal fixation system according to claim 14, wherein the first radial section and the second radial section are approximately equal.

24. The spinal fixation system according to claim 14, wherein when the spinal fixation system is implanted in the first vertebral body, the first region of the third exposed portion of the rod is associated with an anterior side of the first vertebral body and the second region of the third exposed portion of the rod is associated with a posterior side of the first vertebral body.

25. The spinal fixation system according to claim 14, wherein the first area and the second area are longitudinally spaced apart.

26. The spinal fixation system according to claim 14, wherein the bone growth promoting agent is applied to the first area in a spotted pattern comprising a plurality of spaced apart spots.

27. The spinal fixation system according to claim 26, wherein the spaced apart spots vary in shape.

28. The spinal fixation system according to claim 14, wherein the bone growth promoting agent is applied to the first area in a geometric pattern comprising a checkerboard.

29. A spinal fixation system, comprising:

a screw configured for implantation into at least one vertebral body, the screw including a screw body;

a rod; and

a coupling device that couples the rod to the screw with the screw extending in a direction transverse to the rod,

wherein the rod includes a first covered portion within the coupling device and a second exposed portion outside the coupling device,

wherein the second exposed portion of the rod includes a first region and a second region,

wherein the first region of the second exposed portion of the rod is a first radial section of the rod and wherein the second region of the second exposed portion of the rod is a second remaining radial section of the rod;

wherein the first radial section is limited to a portion of the rod that is visible when viewing the rod from the transverse direction in which the screw extends from the rod;

wherein the first region of the rod has bone growth promoting agent and the second region remains exposed without bone growth promoting agent;

wherein the first region includes a first area having a bone growth promoting agent selectively applied in a first pattern and a second area having a bone growth promoting agent selectively applied in a second pattern; and

wherein the first pattern is different from the second pattern.