Delivery of highly lipophilic agents via medical devices
First Claim
1. A system for delivering a lipophilic agent to a desired area outside a body lumen in order to treat a disease manifesting itself in the body lumen or in organs connected to the body lumen, or to maintain patency of the body lumen, comprising:
- a medical device;
a first lipophilic agent capable of penetrating the body lumen wherein the transfer coefficient of said first lipophilic agent is by an amount of at least 5,000 (μ
g/mL)−
1, wherein said first lipophilic agent comprises zotarolimus having one of the following structures;
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Accused Products
Abstract
An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent/medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and/or preventing adjacent diseases or maintaining patency of the body lumen.
234 Citations
33 Claims
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1. A system for delivering a lipophilic agent to a desired area outside a body lumen in order to treat a disease manifesting itself in the body lumen or in organs connected to the body lumen, or to maintain patency of the body lumen, comprising:
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a medical device; a first lipophilic agent capable of penetrating the body lumen wherein the transfer coefficient of said first lipophilic agent is by an amount of at least 5,000 (μ
g/mL)−
1, wherein said first lipophilic agent comprises zotarolimus having one of the following structures; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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Specification