Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
First Claim
1. A method for reducing vascularization in a subject or tissue comprising administering to the subject or tissue in need of such a reduction, in an amount sufficient to reduce vascularization, one or more nucleic acid molecules comprising a nucleic acid sequence 17 to 110 nucleotides in length that is at least 80% identical to miR-31.
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Abstract
The present invention concerns methods and compositions for diagnosing and/or treating vascular diseases including cancer, cardiac diseases, vascular diseases of the eye, and inflammatory diseases. The methods involve measuring the levels of one or multiple miRNAs in patient samples and using the test results to diagnose and/or predict an optimal treatment regimen for the patient. Compositions described in the invention include nucleic acids that function as miRNAs or miRNA inhibitors that can be introduced to a patient to reduce or increase vascularization as needed.
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Citations
16 Claims
- 1. A method for reducing vascularization in a subject or tissue comprising administering to the subject or tissue in need of such a reduction, in an amount sufficient to reduce vascularization, one or more nucleic acid molecules comprising a nucleic acid sequence 17 to 110 nucleotides in length that is at least 80% identical to miR-31.
- 9. A method for reducing vascularization in a subject or tissue comprising administering to the subject or tissue in need of such a reduction, in an amount sufficient to reduce vascularization, a vector comprising a nucleic acid molecule encoding a nucleic acid sequence that comprises a sequence that is at least 80% identical to miR-31.
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