Raman analysis of tissue and/or calcifications
First Claim
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1. A method of probing a sample of living tissue including one or more calcifications, the method comprising:
- directing incident radiation at a first surface of the sample;
discriminating between backscattered elements, and forward scattered and transmitted elements of said incident radiation by said sample, and collecting said forward scattered and transmitted elements of said incident radiation from a second surface of the sample, the second surface being spaced from said first surface such that at least a portion of said tissue lies directly between said first and second surfaces; and
detecting Raman radiation arising from Raman scattering by said one or more calcifications in the collected radiation.
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Abstract
Non invasive in-vivo measurement of composition of a tissue within a part of a human or animal subject is carried out by detecting a Raman spectral characteristic in light scattered through the part using a transmission, rather than a backscattering geometry. The technique is applied to the detection of calcifications in human breast tissues.
58 Citations
16 Claims
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1. A method of probing a sample of living tissue including one or more calcifications, the method comprising:
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directing incident radiation at a first surface of the sample; discriminating between backscattered elements, and forward scattered and transmitted elements of said incident radiation by said sample, and collecting said forward scattered and transmitted elements of said incident radiation from a second surface of the sample, the second surface being spaced from said first surface such that at least a portion of said tissue lies directly between said first and second surfaces; and detecting Raman radiation arising from Raman scattering by said one or more calcifications in the collected radiation. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. Apparatus for non invasive in-vivo measurement of composition of one or more calcifications comprised in a tissue within human or animal subject, the apparatus comprising:
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illumination optics arranged to direct probe light at a first surface of the subject; collection optics arranged so as to discriminate between backscattered light elements, and forward scattered and transmitted light elements by a portion of said tissue which receives said probe light, wherein said portion of said tissue lies between the first surface of the subject and a second surface of the subject, the second surface being spaced from said first surface such that said portion of said tissue lies directly between said first and second surfaces, and said collection optics being arranged to collect, from the second surface of the subject, said forward scattered and transmitted light elements by said portion of said tissue which lies between said first and second surfaces; a light source arranged to provide said probe light to the illumination optics; and an analyser adapted to receive collected light from the collection optics and to determine one or more Raman spectral characteristics of the collected light, for said one or more calcifications. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16)
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Specification