Method for reducing phrenic nerve stimulation

• US 8,260,421 B2
• Filed: 05/22/2008
• Issued: 09/04/2012
• Est. Priority Date: 04/26/2005
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Sathaye, Alok
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): SARCIONE, JESSICA LYNN
• Application Number:
  US12/154,411
• Publication Number:
  US 20080300644A1
• Time in Patent Office: 1,566 Days
• Field of Search: 607/9, 607/27, 600/510
• US Class Current: 607/27
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold

Abstract

Methods and devices for reducing phrenic nerve stimulation of cardiac pacing systems involve delivering a pacing pulse to a ventricle of a heart. A transthoracic impedance signal is sensed, and a deviation in the signal resulting from the pacing pulse may be used to determine phrenic nerve stimulation. Methods may further involve detecting the phrenic nerve stimulation from the pacing pulse by delivering two or more pacing pulse to the ventricle of the heart, and determining a temporal relationship. A pacing vector may be selected from the two or more vectors that effects cardiac capture and reduces the phrenic nerve stimulation. A pacing voltage and/or pulse width may be selected that provides cardiac capture and reduces the phrenic nerve stimulation. In other embodiments, a pacing pulse width and a pacing voltage may be selected from a patient'"'"'s strength-duration curve that effects cardiac capture and reduces the phrenic nerve stimulation.

Claims

1. A method, comprising:

delivering pacing pulses to a ventricle of a heart using one of a plurality of pacing vectors;

sensing a transthoracic impedance signal;

detecting a breathing event based on a temporal association between pacing pulse delivery during a non-refractory period of the heart and a perturbation in the transthoracic impedance signal; and

verifying that the detected breathing event is representative of phrenic nerve stimulation resulting from pacing pulse delivery based on detection of an additional perturbation in the transthoracic impedance signal that is temporally associated with an additional pacing pulse delivered during a cardiac refractory period of the heart.

2. The method of claim 1, comprising selecting a pacing vector from the plurality of vectors that effects cardiac capture and reduces the phrenic nerve stimulation.

3. The method of claim 1, comprising selecting a pacing pulse width and a pacing voltage from a preestablished patient strength-duration curve that effects cardiac capture and reduces the phrenic nerve stimulation.

4. The method of claim 1, comprising detecting the breathing event and verifying that the breathing event is representative of phrenic nerve stimulation based on detection of a change in one or both of inspiration and expiration superimposed over a normal breathing pattern, where the change corresponds with pacing pulse delivery timing.

5. The method of claim 1, comprising opening a time window following delivery of each pacing pulse, and evaluating the transthoracic impedance signal during the time window for the perturbation indicative of phrenic nerve stimulation.

6. The method of claim 5, comprising opening the time window following delivery of a left-ventricular pacing pulse and closing the time window after expiration of a predetermined period following left-ventricular pacing pulse delivery.

7. The method of claim 1, comprising evaluating the transthoracic impedance signal for an inspiration event within an evaluation window defined by the pacing pulse and about 500 milliseconds following the pacing pulse.

8. The method of claim 1, comprising altering one or more of a pacing vector, pacing pulse amplitude, and pacing pulse width to reduce the phrenic nerve stimulation.

9. The method of claim 1, comprising searching for one or more of new pacing vectors, pacing parameter settings, and pulse generator control parameters that effect capture with reduced phrenic nerve stimulation.

10. The method of claim 1, comprising changing, in response to operating in an ambulatory mode, a pacing vector or one or more pacing parameters, waiting for the next scheduled pacing pulse to be delivered, and determining if capture occurs using the changed pacing vector or the one or more changed pacing parameters.

11. The method of claim 1, comprising band-pass filtering, centered at a pacing rate, the transthoracic impedance signal to detect the perturbation in the transthoracic impedance signal indicative of phrenic nerve stimulation.

12. The method of claim 1, comprising verifying that the detected breathing event is representative of phrenic nerve stimulation resulting from pacing pulse delivery independent of cardiac motion.

13. A method, comprising:

delivering pacing pulses to a ventricle of a heart using one of a plurality of pacing vectors;

sensing a transthoracic impedance signal;

detecting a breathing event based on a temporal association between pacing pulse delivery during a non-refractory period of the heart and a perturbation in the transthoracic impedance signal; and

verifying that the detected breathing event is representative of phrenic nerve stimulation resulting from pacing pulse delivery based on detection of an additional perturbation in the transthoracic impedance signal that is temporally associated with an additional delivered pacing pulse.

14. The method of claim 13, comprising selecting a pacing vector from the plurality of vectors that effects cardiac capture and reduces the phrenic nerve stimulation.

15. The method of claim 13, comprising selecting a pacing pulse width and a pacing voltage from a preestablished patient strength-duration curve that effects cardiac capture and reduces the phrenic nerve stimulation.

16. The method of claim 13, comprising detecting the breathing event and verifying that the breathing event is representative of phrenic nerve stimulation based on detection of a change in one or both of inspiration and expiration superimposed over a normal breathing pattern, where the change corresponds with pacing pulse delivery timing.

17. The method of claim 13, comprising opening a time window following delivery of each pacing pulse, and evaluating the transthoracic impedance signal during the time window for the perturbation indicative of phrenic nerve stimulation.

18. The method of claim 17, comprising opening the time window following delivery of a left-ventricular pacing pulse and closing the time window after expiration of a predetermined period following left-ventricular pacing pulse delivery.

19. The method of claim 13, comprising evaluating the transthoracic impedance signal for an inspiration event within an evaluation window defined by the pacing pulse and about 500 milliseconds following the pacing pulse.

20. The method of claim 13, comprising altering one or more of a pacing vector, pacing pulse amplitude, and pacing pulse width to reduce the phrenic nerve stimulation.

21. The method of claim 13, comprising searching for one or more of new pacing vectors, pacing parameter settings, and pulse generator control parameters that effect capture with reduced phrenic nerve stimulation.

22. The method of claim 13, comprising changing, in response to operating in an ambulatory mode, a pacing vector or one or more pacing parameters, waiting for the next scheduled pacing pulse to be delivered, and determining if capture occurs using the changed pacing vector or the one or more changed pacing parameters.

23. The method of claim 13, comprising band-pass filtering, centered at a pacing rate, the transthoracic impedance signal to detect the perturbation in the transthoracic impedance signal indicative of phrenic nerve stimulation.

24. The method of claim 13, comprising verifying that the detected breathing event is representative of phrenic nerve stimulation resulting from pacing pulse delivery independent of cardiac motion.

25. The method of claim 13, comprising:

transmitting information associated with the sensed cardiac signal and the sensed transthoracic impedance signal to a patient-external device;

receiving pacing signal information from the patient-external device; and

altering one or more of the pacing vector, a pacing parameter, and a pacing pulse characteristic based on the received pacing signal information.