Applicators for multiple component formulations and the like, and methods of use thereof

• US 8,262,608 B2
• Filed: 01/25/2008
• Issued: 09/11/2012
• Est. Priority Date: 01/25/2007
• Status: Active Grant

• Current Assignee: SQUARE 1 BANK
• Original Assignee: HyperBranch Medical Technology, Inc. (Stryker Corporation)
• Inventors: Clark, Jeffrey G., D'Alessio, Keith R.
• Primary Examiner(s): Lucchesi, Nicholas
• Assistant Examiner(s): Eisenberg, Rebecca E
• Application Number:
  US12/019,996
• Publication Number:
  US 20080195040A1
• Time in Patent Office: 1,691 Days
• Field of Search: 604/87, 604 89- 92, 433/80, 433/82, 433/83, 433/90, 433/216, 433/217.1
• US Class Current: 604/91
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 2017/00495 for two-component glue
• CPC Class Codes: A61B 2017/320012 Brushes
• CPC Class Codes: A61B 2090/037 with a frangible part, e.g. by reduced diameter
• CPC Class Codes: A61J 1/065 Rigid ampoules, e.g. glass ampoules
• CPC Class Codes: A61J 1/2093 Containers having several compartments for products to be mixed
• CPC Class Codes: A61M 35/006 using sponges, foams, absorbent pads or swabs as spreading means

Abstract

One aspect of the invention relates to an applicator system, and methods of use thereof, that can be used to house separately one or more liquids and one or more solids (e.g., components of a polymerizable hydrogel). In certain embodiments, the applicator systems are further designed to facilitate the mixing of the solids and liquids inside the applicator. In addition, in certain embodiments, the applicator systems are also designed to facilitate the application of the mixture to a surface.

Claims

1. A kit comprising an applicator body and a brush/bladder assembly;

wherein

the applicator body comprises a storage receptacle for a liquid portion, a closed proximal end, an open distal end, and a first friable seal or a removable separator separating the storage receptacle for the liquid portion from the open distal end, the storage receptacle for the liquid portion comprising a buffered solution of polyethyleneimine (PEI);

the brush/bladder assembly comprises a flow-thru brush tip, a cap and a bladder;

the tip comprises an open proximal end and an open distal end;

the cap fits snugly onto the exterior surface of the flow-thru brush tip;

the bladder comprises an open distal end connected to the open proximal end of the tip, an open proximal end configured to attach to the open distal end of the applicator body, and a powdered activated poly(ethylene) glycol (PEG); and

the powdered activated PEG activated ends.

2. The kit of claim 1, wherein the applicator body and the brush/bladder assembly are placed in separate foil bags or separate cavities within a single foil pouch.

3. An applicator, comprising an applicator body, a tip, and a bladder;

wherein

the applicator body comprises a storage receptacle for a liquid portion, a closed proximal end, an open distal end, and a friable seal or a removable separator separating the storage receptacle for the liquid portion from the open distal end, the storage receptacle for the liquid portion comprising a buffered solution of polyethyleneimine (PEI);

the tip is a flow-thru brush comprising an open proximal end and an open distal end;

the bladder comprises an open proximal end connected to the open distal end of the applicator body, an open distal end connected to the open proximal end of the tip, and an powdered activated poly(ethylene) glycol (PEG); and

the powdered activated PEG has activated ends.