Sensor arrangement and method for detecting a sensor event

• US 8,262,875 B2
• Filed: 09/01/2005
• Issued: 09/11/2012
• Est. Priority Date: 09/17/2004
• Status: Active Grant

• Current Assignee: Boehringer Ingelheim Vetmedica GmbH (C.H. Boehringer Sohn AG & Co. KG)
• Original Assignee: Siemens AG
• Inventors: Paulus, Christian, Schienle, Meinrad, Thewes, Roland, Esposti, Claudio Stagni Degli
• Primary Examiner(s): Ball, J. Christopher
• Application Number:
  US11/663,078
• Publication Number:
  US 20080036444A1
• Time in Patent Office: 2,567 Days
• Field of Search: 204400-435, 205775-7945, 438/10, 324/71.1
• US Class Current: 204/406
• CPC Class Codes: G01N 27/3276 being a hybridisation with immobilised receptors using a FET type sensor G01N27/4145; concerning the hybridisation C12Q1/68

Abstract

A sensor arrangement including a control circuit is disclosed. In at least one embodiment, at least one sensor electrode can be charged and/or discharged therewith and a comparator unit for the comparison of a provided voltage for the at least one electrode with a reference voltage. A duration necessary for the charging/discharging of the at least one sensor electrode is determined, whereby, from the determined duration, it is determined whether a sensor event, in the form of a hybridization between trap molecules and the particles for recording, has occurred.

Claims

1. A sensor arrangement, comprising:

at least one electrode;

a sensor element dependent on a sensor event in terms of its profile, at the at least one electrode;

a drive circuit, to provide an electric current source at a constant magnitude as a predetermined electric current, the at least one electrode being at least one of charged and discharged with the predetermined electric current;

a comparator unit, to compare the electrical voltage provided by the sensor element with a reference voltage, and to provide a comparison result;

a voltage source, to provide the reference voltage to the comparator, the voltage source being coupled to the comparator unit;

an evaluation circuit that receives an output signal from the comparator unit, to determine a time duration required for the at least one of charging and discharging of the electrode, from at least one of a predetermined voltage to the reference voltage and from the reference voltage to the predetermined voltage, the time duration representing at least one of whether or not a sensor event has taken place and the extent to which a sensor event has taken place at the sensor element;

a switch unit, configured to invert a flow direction of the current from the drive circuit, the switch unit being connected between the drive circuit and the comparator unit, the electrode being charged or discharged depending on the switch state; and

a control unit for controlling the switch unit such that, by way of the switch unit, with changeover of the switch unit, the electrode is repeatedly at least one of charged from the predetermined voltage to the reference voltage and discharged from the reference voltage to the predetermined voltage, wherein the sensor element is connected between the switch unit and the comparator.

2. The sensor arrangement as claimed in claim 1, wherein the sensor element includes at least two electrodes mounted thereon.

3. The sensor arrangement as claimed in claim 2, wherein the at least two electrodes are arranged such that the two electrodes intermesh in comb-type fashion.

4. The sensor arrangement as claimed in claim 2, wherein two electrodes are arranged such that the two electrodes intermesh in comb-type fashion, and wherein a third electrode is arranged in meandering fashion between the two electrodes.

5. The sensor arrangement as claimed in claim 1, wherein the comparator unit is a comparator.

6. The sensor arrangement as claimed in claim 1, wherein the control unit is set up such that the switch state of the switch unit is changed over if the voltage of the electrode is the reference voltage or the predetermined voltage.

7. The sensor arrangement as claimed in claim 1, further comprising a sensor event determining unit, configured to determine whether a sensor event has taken place is determined from the determined time durations of at least one of the charging operation and the discharging operation.

8. The sensor arrangement as claimed in claim 7, wherein the sensor event determining unit is set up in such a way that at least one of a charging frequency and a discharging frequency and a cycle frequency, where a cycle in each case has a charging operation and a discharging operation, is determined from the determined time durations of at least one of the charging operation and of the discharging operation.

9. The sensor arrangement as claimed in claim 1, wherein the sensor element is set up as a biosensor element for the detection of biomolecules.

10. The sensor arrangement as claimed in claim 1, further comprising a plurality of sensor elements.

11. The sensor arrangement as claimed in claim 9, wherein the sensor elements are arranged in matrix-type fashion.

12. The sensor arrangement as claimed in claim 1, wherein the sensor event is a hybridization event.

13. The sensor arrangement as claimed in claim 1, further comprising a further switch unit between the sensor element and the comparator, wherein the drive circuit is directly connected to the switch unit and the further switch unit is directly connected to the voltage source and the comparator.

14. A method for determining a sensor event at a sensor element, the method comprising:

at least one of charging and discharging at least one electrode by way of a predetermined electric current at a constant magnitude;

determining a time duration required for the at least one of charging and discharging of the electrode, at least one of from a predetermined voltage generated by a drive circuit to a reference voltage generated by a voltage source arranged between a comparator and the sensor element and from the reference voltage to the predetermined voltage, the time duration being dependent on at least one of whether or not a sensor event has taken place at the sensor element, connected between the drive circuit and the comparator and the extent to which a sensor event has taken place at the sensor element; and

using the determined time duration to determine whether a hybridization event has taken place.

15. A sensor arrangement, comprising:

at least one electrode;

a sensor element dependent on a sensor event in terms of its profile, at the at least one electrode;

a drive circuit, to provide an electric current source at a constant magnitude as a predetermined electric current, the at least one electrode being at least one of charged and discharged with the predetermined electric current;

a comparator unit, to compare the electrical voltage provided by the sensor element with a reference voltage, and to provide a comparison result;

a voltage source, to provide a reference voltage to the comparator, the voltage source being coupled to the comparator unit;

an evaluation circuit that receives an output signal from the comparator unit, to determine a time duration required for the at least one of charging and discharging of the electrode, from at least one of a predetermined voltage to the reference voltage and from the reference voltage to the predetermined voltage, the time duration representing at least one of whether or not a sensor event has taken place and the extent to which a sensor event has taken place at the sensor element; and

a switch unit directly connected to the voltage source and the comparator.