Systems and methods including amperometric and voltammetric duty cycles
First Claim
1. A method for measuring an analyte in a sample, comprising:
- applying to the sample an input signal comprising a first duty cycle including an amperometric excitation and a first relaxation and a second duty cycle including a voltammetric excitation and a second relaxation;
detecting an output signal, the output signal including output currents responsive to the amperometric excitation and output currents responsive to the voltammetric excitation;
adjusting a potential of the amperometric excitation in response to the output currents responsive to the voltammetric excitation; and
correlating a portion of the output signal with a concentration of at least one analyte in the sample.
2 Assignments
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Accused Products
Abstract
A sensor system including devices and methods for determining the concentration of an analyte in a sample is described. Input signals including amperometric and voltammetric duty cycles of excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed system may reduce analysis errors, thus improving measurement performance, by adjusting the potential and/or scan rate in response to output currents obtained from voltammetric scans. The disclosed system also may determine the concentration of more than one ionizable species in the sample by adjusting the potential and/or scan rate in response to output currents obtained from voltammetric scans. The multiple, determined concentrations may be used to determine the concentration of multiple analytes or to correct the concentration determined for an analyte, thus improving the measurement performance of the system.
27 Citations
34 Claims
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1. A method for measuring an analyte in a sample, comprising:
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applying to the sample an input signal comprising a first duty cycle including an amperometric excitation and a first relaxation and a second duty cycle including a voltammetric excitation and a second relaxation; detecting an output signal, the output signal including output currents responsive to the amperometric excitation and output currents responsive to the voltammetric excitation; adjusting a potential of the amperometric excitation in response to the output currents responsive to the voltammetric excitation; and correlating a portion of the output signal with a concentration of at least one analyte in the sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method for measuring an analyte in a sample, comprising:
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applying to the sample an input signal comprising a first duty cycle including a voltammetric excitation and a first relaxation and a second duty cycle including an acyclic scan and a second relaxation; detecting an output signal, the output signal including output currents responsive to the voltammetric excitation and output currents responsive to the acyclic scan; adjusting a scan range of the acyclic scan in response to the output currents responsive to the voltammetric excitation; and correlating a portion of the output signal with a concentration of at least one analyte in the sample. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A method for measuring an analyte in a sample, comprising:
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applying to the sample an input signal comprising a first duty cycle including an amperometric excitation and a first relaxation, a second duty cycle including a voltammetric excitation and a second relaxation, and a third duty cycle including an acyclic scan and a third relaxation; detecting an output signal, the output signal including output currents responsive to the amperometric excitation and output currents responsive to the voltammetric excitation; adjusting a potential of the acyclic scan of the third duty cycle in response to the output currents responsive to the voltammetric excitation; and correlating a portion of the output signal with a concentration of at least one analyte in the sample. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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Specification