Coated surfaces for immobilizing negatively charged anticoagulating agents from blood fluid
First Claim
1. A coating for a surface comprising:
- at least a first coating, a second coating, and a third coating, wherein the first coating is in contact with at least a portion of the surface and the second coating is disposed between the first and the third coating, with the second coating comprising a high molecular weight negatively charged polymer,wherein the first coating, the third coating, or both the first coating and the third coating comprises water soluble butylated polyethyleneimine anda fourth coating of heparin on the third coating.
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Accused Products
Abstract
A wound closure apparatus is provided which utilizes blood fluid by activating the clotting cascade of blood fluid outside the body within a substantially enclosed sterile container then introducing, the blood fluid to the wound site to complete clotting. An apparatus for providing ways of inhibiting anticoagulating agents, and slowing fibrin clot degradation are also disclosed. Kits for practicing the invention singularly or in combination with, and/or associated with preferred procedures are also disclosed. The invention provides a clotting cascade initiation apparatus (1) including a substantially enclosed sterile containment chamber within which an aliquot of blood fluid, either autologous or from donor sources can be received, and retained. In preferred embodiments, the sterile containment chamber further includes a heparin binding agent which will bind heparin and remove it from the blood fluid. In further embodiments, the containment chamber will also include a procoagulating agent, wherein a clotting cascade can be initiated when the blood fluid is accepted into the sterile containment chamber.
64 Citations
23 Claims
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1. A coating for a surface comprising:
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at least a first coating, a second coating, and a third coating, wherein the first coating is in contact with at least a portion of the surface and the second coating is disposed between the first and the third coating, with the second coating comprising a high molecular weight negatively charged polymer, wherein the first coating, the third coating, or both the first coating and the third coating comprises water soluble butylated polyethyleneimine and a fourth coating of heparin on the third coating. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A coating for a surface comprising:
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at least a first coating, a second coating, and a third coating, wherein the first coating is in contact with at least a portion of the surface and the second coating is disposed between the first and the third coating, the first and third coatings comprising polyethyleneimine and the second coating comprising polyacrylic acid with a molecular weight of at least 3,000,000, and a fourth coating on the third coating that comprises heparin. - View Dependent Claims (15)
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16. A method for coating a surface comprising:
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coating at least a portion of the surface with a first coating of a positively charged polymer; coating at least a portion of the first coating with a second coating that contacts the first coating, wherein the second coating includes a high molecular weight negatively charged polymer; and coating at least a portion of the second coating with a third coating of a positively charged polymer that contacts the second coating, wherein the positively charged polymer in the first coating, the third coating, or both the first coating and the third coating comprises water soluble butylated polyethyleneimine, and further comprising applying a layer of heparin to the third coating by exposing the third coating to a solution that comprises the heparin. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23)
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Specification