Devices and formulations for detecting, screening and monitoring levels of certain constituents in bodily fluids and method
First Claim
1. A method of making a device for conducting a non-invasive analysis of a bodily fluid to determine the presence and the level of a certain constituent carried by the bodily fluid, the device including an indicator formulation capable of changing color in response to exposure to the certain constituent in the presence of ambient air to provide a visible indication of the presence and the level of the certain constituent carried by the bodily fluid, the method comprising:
- providing a target area on a carrier substrate of a fibrous material having fibers and voids in a high void volume in juxtaposition with the target area and with fibers within the carrier substrate, with voids establishing communication between fibers and ambient air;
wherein the carrier substrate has a total volume and the high void volume is within a range of about eight to twelve percent of the total volume;
applying a chromagen formulation to fibers of the carrier substrate to create a chromagen-laden carrier member wherein applied chromagen formulation carried on fibers is placed in juxtaposition with voids in the carrier substrate for enabling exposure to ambient air within the voids; and
subsequently applying to the chromagen formulation carried on fibers of the chromagen-laden carrier member a selected reagent having a particular constituent-specific formulation to combine the selected reagent with the chromagen formulation on fibers of the carrier member, thereby establishing the indicator formulation on fibers of the carrier member, in juxtaposition with voids within the carrier substrate and with the target area, in place for communication with ambient air within the voids and reception of a sample of the bodily fluid later placed upon the target area of the carrier substrate and in communication with ambient air within the voids for enabling reaction with the indicator formulation on the fibers, with the sample exposed to ambient air present in the juxtaposed voids as the certain constituent in the sample reacts with the indicator formulation.
1 Assignment
0 Petitions
Accused Products
Abstract
A device is disclosed for conducting a non-invasive analysis of a bodily fluid to determine the presence and level of a certain constituent carried by the bodily fluid. An indicator formulation of the device changes color in response to exposure to the constituent to provide a visible indication of the presence and level of the constituent carried by the bodily fluid. A carrier substrate of the device is constructed of a material having voids providing a high void volume within the substrate. The device is made by applying a chromagen to the carrier substrate to create a chromagen-laden carrier member. Then, a selected reagent having a particular constituent-specific formulation is applied to the chromagen-laden member. The selected reagent then combines with the chromagen, thereby establishing the indicator formulation within the carrier substrate in place for reception of a sample of the bodily fluid.
-
Citations
14 Claims
-
1. A method of making a device for conducting a non-invasive analysis of a bodily fluid to determine the presence and the level of a certain constituent carried by the bodily fluid, the device including an indicator formulation capable of changing color in response to exposure to the certain constituent in the presence of ambient air to provide a visible indication of the presence and the level of the certain constituent carried by the bodily fluid, the method comprising:
-
providing a target area on a carrier substrate of a fibrous material having fibers and voids in a high void volume in juxtaposition with the target area and with fibers within the carrier substrate, with voids establishing communication between fibers and ambient air; wherein the carrier substrate has a total volume and the high void volume is within a range of about eight to twelve percent of the total volume; applying a chromagen formulation to fibers of the carrier substrate to create a chromagen-laden carrier member wherein applied chromagen formulation carried on fibers is placed in juxtaposition with voids in the carrier substrate for enabling exposure to ambient air within the voids; and subsequently applying to the chromagen formulation carried on fibers of the chromagen-laden carrier member a selected reagent having a particular constituent-specific formulation to combine the selected reagent with the chromagen formulation on fibers of the carrier member, thereby establishing the indicator formulation on fibers of the carrier member, in juxtaposition with voids within the carrier substrate and with the target area, in place for communication with ambient air within the voids and reception of a sample of the bodily fluid later placed upon the target area of the carrier substrate and in communication with ambient air within the voids for enabling reaction with the indicator formulation on the fibers, with the sample exposed to ambient air present in the juxtaposed voids as the certain constituent in the sample reacts with the indicator formulation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
-
Specification