Non-sedating antihistamine injection formulations and methods of use thereof
First Claim
1. A method of treating acute urticaria associated with an acute allergic reaction comprising administering to an individual in an emergency situation an effective amount of an injectable composition comprising a non-sedating antihistamine, wherein the non-sedating antihistamine comprises racemic cetirizine or a salt thereof, wherein the injectable composition is in an aqueous solution having a pH of 3 to 9, and wherein administering comprises administration of 2 to 10 mg of racemic cetirizine.
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Abstract
Described herein are injectable compositions containing non-sedating or second and third generation antihistamines such as cetirizine/levocetirizine and methods of use thereof. Specifically, methods of treating acute allergic reactions including anaphylaxis with the compositions are disclosed. In certain embodiments, the injectable compositions are bioequivalent to currently marketed oral dosage forms. In other embodiments, the non-sedating or second and third generation antihistamine injectable formulations are therapeutically equivalent to diphenhydramine injectable formulations and/or are more effective than placebo. In other embodiments, a non-sedating antihistamine injectable composition is delivered by an autoinjector.
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Citations
9 Claims
- 1. A method of treating acute urticaria associated with an acute allergic reaction comprising administering to an individual in an emergency situation an effective amount of an injectable composition comprising a non-sedating antihistamine, wherein the non-sedating antihistamine comprises racemic cetirizine or a salt thereof, wherein the injectable composition is in an aqueous solution having a pH of 3 to 9, and wherein administering comprises administration of 2 to 10 mg of racemic cetirizine.
Specification