Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
First Claim
Patent Images
1. A method comprising:
- providing a substrate comprising a regular array of more than 100 discrete sources of optical signals;
designating an array of subsets of pixels to correspond with the images of the array of the more than 100 discrete sources on a detector as high fidelity pixels and designating another set of pixels on the detector as low fidelity pixels;
thenilluminating the array of discrete sources with an excitation light source, whereby emitted lights emitted from the discrete sources, the emitted light corresponding to signals, from the discrete sources;
directing the emitted light onto the detector;
combining the data from the pixels within each set of high fidelity data for each discrete source; and
processing the combined data to provide information about the signals from the discrete sources.
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Abstract
Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.
126 Citations
21 Claims
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1. A method comprising:
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providing a substrate comprising a regular array of more than 100 discrete sources of optical signals; designating an array of subsets of pixels to correspond with the images of the array of the more than 100 discrete sources on a detector as high fidelity pixels and designating another set of pixels on the detector as low fidelity pixels;
thenilluminating the array of discrete sources with an excitation light source, whereby emitted lights emitted from the discrete sources, the emitted light corresponding to signals, from the discrete sources; directing the emitted light onto the detector; combining the data from the pixels within each set of high fidelity data for each discrete source; and processing the combined data to provide information about the signals from the discrete sources. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A system comprising:
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a substrate comprising a regular array of more than 100 discrete sources of optical signals; an optical train configured to direct excitation, radiation from an excitation source to the regular array of more than 100 discrete sources, receive emitted optical signals from the array of discrete sources, and image the emitted optical signals onto a detector comprising an array of pixels; wherein the detector has, for each discrete source, a regular array of subsets of pixels that correspond to expected images of the discrete sources, which are designated as a set of high fidelity pixels, and other pixels on the detector are designated as low fidelity pixels; and a first processor configured for combining the data from the pixels within each set of high fidelity data for each discrete source; and a second processor configured for processing the combined data to provide information about the signals from the discrete sources. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification