Control of fluid transfer operations

• US 8,267,129 B2
• Filed: 11/09/2007
• Issued: 09/18/2012
• Est. Priority Date: 11/09/2006
• Status: Active Grant

• Current Assignee: ArXium, Inc. (Van Humbeck Family)
• Original Assignee: Intelligent Hospital Systems, Inc. (Van Humbeck Family)
• Inventors: Doherty, Thom, Eliuk, Walter W., Jones, Richard L.
• Primary Examiner(s): HWU, DAVIS D
• Application Number:
  US11/937,846
• Publication Number:
  US 20080114328A1
• Time in Patent Office: 1,775 Days
• Field of Search: 141/330, 141/25, 141/27, 141/95, 141/198, 141/2, 141/1, 534/51, 534/68
• US Class Current: 141/330
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2044 having slits
• CPC Class Codes: A61J 1/2055 having gripping means
• CPC Class Codes: A61J 1/2065 having aligning and guiding means
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents
• CPC Class Codes: A61J 2200/10 Coring prevention means, e.g. for plug or septum piecing members
• CPC Class Codes: A61J 3/002 Compounding apparatus specially for enteral or parenteral nutritive solutions bottling liquids B67C
• CPC Class Codes: B65B 3/003 Filling medical containers such as ampoules, vials, syringes or the like

Abstract

Some methods and related apparatus for manipulating a fluid conduit for insertion into a substantially re-sealable membrane include determining an orientation and position of a fluid conduit relative to the membrane. In an illustrative example, a syringe needle having a beveled leading edge may be manipulated by an automated device to be oriented and aligned with an aperture made upon a previous insertion of a needle into a membrane. In some examples, a predetermined number of insertions may be made in the same aperture by aligning and orienting one or more needles with the aperture. In some examples, multiple needle insertions may be controlled to produce apertures that are substantially spaced apart. Such procedures may, for example, advantageously extend the integrity of the membrane against leakage and/or contamination.

Claims

1. An automated method of providing fluid communication through a self-sealing membrane, the method comprising:

a) operating an articulated conveyor to retrieve a first fluid conduit having a beveled leading edge;

b) creating a first aperture in a re-sealable fluid port membrane by piercing the membrane with the first fluid conduit;

c) operating the articulated conveyor to retrieve an additional fluid conduit having a beveled leading edge;

d) determining alignment and orientation of the additional fluid conduit relative to the first aperture;

e) registering and orienting the additional fluid conduit for entry into the first aperture; and

f) inserting the additional fluid conduit through the first aperture and in substantial alignment with the first aperture.

2. The method of claim 1, further comprising beginning to perform step d) before beginning to perform step c).

3. The method of claim 1, further comprising repeating steps c) through f) at least two times.

4. The method of claim 1, wherein step f) comprises inserting the additional fluid conduit without substantially enlarging the first aperture.

5. The method of claim 1, further comprising transferring a fluid through the additional fluid conduit while the additional fluid conduit is inserted in the first aperture.

6. The method of claim 1, further comprising transferring a fluid through the first fluid conduit while the first fluid conduit is inserted in the first aperture.

7. The method of claim 1, wherein the re-sealable fluid port membrane substantially prevents fluid leakage while holding a differential pressure of at least 5 pounds-force per square inch gauge (psig) after at least five insertions.

8. The method of claim 7, wherein the re-sealable fluid port membrane substantially holds the differential pressure of at least 5 psig after at least ten insertions.

9. The method of claim 1, wherein the first fluid conduit comprises a needle.

10. The method of claim 1, wherein the first fluid conduit comprises a cannula.

11. The method of claim 1, wherein the re-sealable fluid port membrane comprises a vial bung.

12. The method of claim 1, wherein the re-sealable fluid port membrane comprises an intravenous (IV) bag fluid port.

13. The method of claim 1, wherein the fluid port membrane seals an opening of a fluid reservoir.

14. The method of claim 13, wherein the fluid reservoir comprises a vial.

15. The method of claim 13, wherein the fluid reservoir comprises an intravenous (IV) bag.

16. The method of claim 13, wherein the fluid reservoir comprises a flexible fluid conduit.

17. The method of claim 13, wherein the fluid reservoir comprises a rigid container.

18. The method of claim 1, wherein the first fluid conduit is the same as at least one of the additional fluid conduits.

19. The method of claim 1, further comprising discarding the first fluid conduit and retrieving the second fluid conduit.

20. The method of claim 1, further comprising creating a second aperture in the re-sealable fluid port membrane by piercing the membrane with another fluid conduit having a beveled leading edge.

21. The method of claim 1, wherein step d) comprises determining an orientation of the beveled leading edge of the additional fluid conduit.

22. The method of claim 1, wherein step d) further comprises rotating the beveled edge of the additional fluid conduit to be in substantial register with the first aperture.

23. The method of claim 1, further comprising positioning the fluid conduit to be a predetermined distance from the surface of the re-sealable fluid port membrane.

24. A computer program product tangibly embodied in a computer readable medium, the computer program product including instructions that, when executed, perform operations for providing fluid communication through a self-sealing membrane, the operations comprising:

a) cause an articulated conveyor to retrieve a first fluid conduit having a beveled leading edge;

b) create a first aperture in a re-sealable fluid port membrane by piercing the membrane with the first fluid conduit;

c) cause the articulated conveyor to retrieve an additional fluid conduit having a beveled leading edge;

d) determine alignment and orientation of the additional fluid conduit relative to the first aperture;

e) register and orient the additional fluid conduit for entry into the first aperture; and

f) insert the additional fluid conduit through the first aperture and in substantial alignment with the first aperture.

25. A method of repeatedly accessing a fluid container to permit fluid transfer, the method comprising:

a) selecting a first location and orientation to insert a leading tip for needles having a beveled leading edge;

b) repeatedly inserting a leading tip of at least one needle at the selected first location and orientation;

c) after performing step b) a predetermined number of times, selecting a second location and orientation to insert a leading tip for at least one needle having a beveled leading edge, wherein a first aperture formed by inserting a needle at the selected first location and orientation will be substantially spaced apart from a second aperture formed by inserting a needle at the selected second location and orientation; and

d) positioning a leading tip of a needle for insertion at the selected second location and orientation, wherein

the first and second apertures are made by insertion of needles through a substantially self-sealing membrane.

26. The method of claim 25, wherein selecting a second location comprises identifying a location at which the second aperture is substantially outside of a predefined keep-out region around the first aperture.

27. The method of claim 25, further comprising inserting a leading tip of at least one needle at the selected second location and orientation.

28. The method of claim 25, wherein step b) comprises making a plurality of insertions with at least two different needles.

29. The method of claim 25, wherein step d) comprises making a plurality of insertions with at least two different needles.

30. The method of claim 25, further comprising:

e) after performing step d) a second predetermined number of times, selecting a third location and orientation to insert a leading tip for at least one needle having a beveled leading edge, wherein the first and second apertures will be substantially spaced apart from a third aperture formed by insertion of a needle at the selected third location and orientation.

31. The method of claim 30, further comprising:

f) positioning a leading tip of a needle for insertion at the selected third location and orientation.

32. A computer program product tangibly embodied in a computer readable medium, the computer program product including instructions that, when executed, perform operations for repeatedly accessing a fluid container to permit fluid transfer, the operations comprising:

a) select a first location and orientation to insert a leading tip for needles having a beveled leading edge;

b) repeatedly insert a leading tip of at least one needle at the selected first location and orientation;

c) after performing step b) a predetermined number of times, select a second location and orientation to insert a leading tip for at least one needle having a beveled leading edge, wherein a first aperture formed by inserting a needle at the selected first location and orientation will be substantially spaced apart from a second aperture formed by inserting a needle at the selected second location and orientation; and

d) position a leading tip of a needle for insertion at the selected second location and orientation, wherein

the first and second apertures are made by insertion of needles through a substantially self-sealing membrane.