Injection device

• US 8,267,899 B2
• Filed: 10/31/2007
• Issued: 09/18/2012
• Est. Priority Date: 06/16/2000
• Status: Expired due to Term

• Current Assignee: Novo Nordisk A/S
• Original Assignee: Novo Nordisk A/S
• Inventors: Møller, Claus Schmidt
• Primary Examiner(s): STIGELL, THEODORE J
• Application Number:
  US11/930,926
• Publication Number:
  US 20080281275A1
• Time in Patent Office: 1,784 Days
• Field of Search: 604207-211, 604/181, 604/187, 604/218
• US Class Current: 604/207
• CPC Class Codes: A61M 2005/3152 including gearings to multiply or attenuate the piston displacing force
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/28 Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
• CPC Class Codes: A61M 5/315 Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
• CPC Class Codes: A61M 5/31541 Means preventing setting of a dose beyond the amount remaining in the cartridge
• CPC Class Codes: A61M 5/3155 by rotational movement of dose setting member, e.g. during setting or filling of a syringe
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member
• CPC Class Codes: A61M 5/31558 using scaling up or down transmissions, e.g. gearbox
• CPC Class Codes: A61M 5/31575 using scaling up or down transmissions, e.g. gearbox
• CPC Class Codes: A61M 5/3158 performed by axially moving actuator operated by user, e.g. an injection button

Abstract

A medication dispensing device with a housing and a member wherein the member is moveable in a distal direction is useful in delivering medication to a patient. A fluid container can be used with the device and often has a moveable piston at one end and an outlet at the other. The member receives a force from a user and drives the piston in the distal direction to expel medication. A intermediate system is disposed between the member and the piston including a gear set that has a pinion in meshed engagement with a rack. The system allows the member to move a greater distance than the piston moves thereby increasing the force on the piston.

Claims

1. A method for expelling medication from an injection device containing a prefilled medication cartridge and having a rack and pinion transmission that couples an injection button with a piston driver;

the method comprising the steps of;

moving a first toothed rack rearward, away from an injecting end of the device, during setting of a dose, the rack remaining in continuous meshed engagement with a pinion causing the pinion to rotate during setting of the dose;

moving the first toothed rack forward, toward the injecting end of the device, during injection of a dose and causing the pinion to rotate in an opposite direction, thereby causing part of the transmission to drive the piston driver forward which in turn moves a piston within the medication cartridge and expels medication from the device, wherein the piston is moveable within the cartridge and closes one end of the cartridge.

2. The method of claim 1, further comprising the step of:

rotating a second smaller pinion at the same speed as the said pinion during the expelling of the medication,

wherein the second pinion is in continuous meshed engagement with a second rack that has a longitudinal axis that is parallel to the first rack.

3. The method of claim 2, wherein the first rack moves forward by a distance greater than the piston is driven forward during injection.

4. A method of expelling medication from an injection device comprising the steps of moving an injection plunging element (19) in a proximal direction during the setting of a dose;

moving a first toothed rack (15) in the proximal direction during setting of a dose, wherein the first rack remains in continuous meshed engagement with a first pinion (14) during setting of the dose;

maintaining continuous meshed engagement of a second pinion (16) with a second toothed rack (10), wherein the first and second pinions revolve around a common axis,

pressing on the plunging element (19) to shift the plunging element (19) from a proximal position to a distal position, wherein as the plunging element moves distally it causes a piston drive element (4) to move a lesser distance than the plunging element and wherein during the distal movement of the plunging element the two pinions move distally while the first pinion remains in meshed engagement with the first rack and the second pinion remains in meshed engagement with the second rack and wherein during the pressing of the plunging element the first rack moves distally with the plunging element.

5. A method for injecting medication from a device having a prefilled cartridge containing medication in a cartridge that has one end closed by a moveable piston, the method comprising the steps of:

moving a plunging rack containing teeth proximally during dose setting until a dose has been set;

moving a gear set comprised of at least one pinion gear wheel proximally during dose setting;

moving the plunging rack distally to inject the set dose;

moving the gear set distally during dose injection;

wherein at least one pinion gear wheel of the gear set remains in continuous meshed engagement with the both the plunging rack and with a rack that is axially fixed within the device during dose setting and dose injecting,

moving a piston driver element a lesser distance during dose injecting than the plunging rack moves whereby the piston driver moves the piston in the cartridge to expel the set dose from the cartridge.

6. The method of claim 5, wherein a second gear wheel is rotatable about the same axis as the first gear wheel and wherein both gear wheels rotate during dose setting and dose injecting.

7. The method of claim 6 further comprising rotating the first and second gear wheels in unison during dose injecting.

8. A method for injecting a device that has a housing and contains a cartridge of medication, wherein the cartridge is closed at one end by a moveable piston, the method comprising the steps of:

setting a dose;

moving a plunging rack proximally;

rotating a gear set comprised of at least one pinion gear wheel, wherein the pinion gear wheel is in continuous meshed engagement with the plunging rack;

moving the plunging rack distally;

causing the pinion gear wheel to rotate during distal movement of the plunging rack;

transferring a force to a piston driver from the plunging rack through the gear set to a piston driver to expel medication;

wherein the gear set moves longitudinally within the device during dose setting and dose injecting.

9. The method of claim 8 further comprising the step of maintaining constant meshed engagement between the at least one pinion gear wheel and a second rack that is longitudinally fixed with respect to the device housing.

10. The method of claim 9 further comprising rotating a second gear wheel of the gear set that is rotatable about the same rotational axis as the at least one gear wheel wherein the rotation is in the same direction as the at least one gear wheel during dose setting and dose injection.

11. The method of claim 10 wherein during injection of medication the at least one gear wheel and the second gear wheel are rotated at the same angular rate.

12. The method of claim 11 wherein both gear wheels translate longitudinally at the same rate.

13. A method for injecting medication from a medication device have a housing and having a cartridge of medication which is closed at one end by a moveable piston, the method comprising the steps of:

setting a dose of medication to be injected;

rotating a dose scale drum away from an initial position to set the dose size;

moving a plunging rack that contains teeth in a proximal direction;

rotating a gear wheel, the gear wheel being in meshed engagement with the plunging rack moving the gear wheel proximally;

moving the plunging rack distally;

rotating the dose scale drum toward the initial position so that the drum is in the initial position when the injection is complete.

14. The method of claim 13, wherein the scale rotates toward the initial position during the injecting procedure and reaches zero upon completion of the injection.