Methods and systems for neural maintenance and regeneration
First Claim
1. A system comprising:
- a neurotrophin release device including a neurotrophin reservoir having at least one neurotrophin, the neurotrophin release device configured for releasing the at least one neurotrophin;
an inhibitor release device including an inhibitor reservoir having at least one inhibitor of degradation of the at least one neurotrophin, the inhibitor release device configured for releasing the at least one inhibitor of degradation of the at least one neurotrophin;
a detector configured to sense a concentration of the at least one neurotrophin and output a sensing signal;
a controller capable of regulating the release of at least one of the at least one neurotrophin from the neurotrophin release device or the at least one inhibitor of degradation from the inhibitor release device, the controller programmed to control cooperatively releasing the at least one neurotrophin from the neurotrophin release device and the at least one inhibitor of degradation of neurotrophin from the inhibitor release device in order to elevate a concentration of the at least one neurotrophin in response to receiving the sensing signal from the detector; and
a connection between the controller and at least one of the neurotrophin release device or the inhibitor release device.
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Accused Products
Abstract
Methods and systems are described that release one or both of a neurotrophin and an inhibitor of the degradation of the neurotrophin within or in the vicinity of a highly innervated tissue. In some embodiments, the method includes regulating the release of the neurotrophin and the inhibitor of degradation over time. In some embodiments, the method includes monitoring the concentration of the neurotrophin over time. The system may include a device or multiple devices for the release of the neurotrophin and the inhibitor as well as a controller. In some embodiments the system may include a sensor device and/or an imaging device capable of detecting the concentration of the neurotrophin over time. The release of the neurotrophin and inhibitor of degradation may be part of a controlled release system and regulated over time.
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Citations
8 Claims
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1. A system comprising:
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a neurotrophin release device including a neurotrophin reservoir having at least one neurotrophin, the neurotrophin release device configured for releasing the at least one neurotrophin; an inhibitor release device including an inhibitor reservoir having at least one inhibitor of degradation of the at least one neurotrophin, the inhibitor release device configured for releasing the at least one inhibitor of degradation of the at least one neurotrophin; a detector configured to sense a concentration of the at least one neurotrophin and output a sensing signal; a controller capable of regulating the release of at least one of the at least one neurotrophin from the neurotrophin release device or the at least one inhibitor of degradation from the inhibitor release device, the controller programmed to control cooperatively releasing the at least one neurotrophin from the neurotrophin release device and the at least one inhibitor of degradation of neurotrophin from the inhibitor release device in order to elevate a concentration of the at least one neurotrophin in response to receiving the sensing signal from the detector; and a connection between the controller and at least one of the neurotrophin release device or the inhibitor release device. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A system comprising:
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a neurotrophin release device including a neurotrophin reservoir having at least one neurotrophin, the neurotrophin release device configured for releasing the at least one neurotrophin; an inhibitor release device including an inhibitor reservoir having at least one inhibitor of degradation of the at least one neurotrophin, the inhibitor release device configured for releasing the at least one inhibitor of degradation of the at least one neurotrophin; a detector configured to sense a concentration of the at least one neurotrophin and output a sensing signal; a controller capable of regulating the release of at least one of the at least one neurotrophin from the neurotrophin release device or the at least one inhibitor of degradation from the inhibitor release device, wherein during operation of the system and in response to receiving the sensing signal from the detector, the controller directs cooperatively releasing the at least one neurotrophin from the neurotrophin release device and the at least one inhibitor of degradation of neurotrophin from the inhibitor release device in order to elevate a concentration of the at least one neurotrophin; and a connection between the controller and at least one of the neurotrophin release device or the inhibitor release device.
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Specification