Inflatable porous implants and methods for drug delivery
First Claim
1. A method for delivering a therapeutic agent, said method comprising:
- providing a graft comprising;
a graft body section having a proximal end, a distal end, and defining at least one inflatable porous channel; and
at least one inflatable porous cuff disposed at the proximal or distal end of the graft body section and in fluid communication with the at least one channel, wherein the at least one inflatable porous cuff is disposed in an axisymmetric cylindrical manner around the proximal or distal end of the graft body section;
providing an inflation medium including at least one therapeutic agent configured to be introduced into the inflatable channel;
wherein the inflation medium comprises a curable liquid comprising a therapeutic agent-carrying host polymer;
implanting the graft body in a body lumen; and
inflating the porous channel with the inflation medium including the at least one therapeutic agent.
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Accused Products
Abstract
The present invention provides inflatable porous implants, such as grafts, stent-grafts, and bladders, as well as methods and kits for drug delivery. In particular, the grafts and stent-grafts of the present invention provide for the delivery of a therapeutic agent into a flow conduit in the body. The inflatable porous implants provide for direct delivery of larger, more precise dosages of drugs over longer administration periods into the body. Moreover, these inflatable porous implants are often flexible when inserted and have a low profile delivery configuration for easy placement. The implants of the present invention further provide a mechanical or structural function in addition to drug delivery in a single integrated structure.
410 Citations
19 Claims
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1. A method for delivering a therapeutic agent, said method comprising:
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providing a graft comprising; a graft body section having a proximal end, a distal end, and defining at least one inflatable porous channel; and at least one inflatable porous cuff disposed at the proximal or distal end of the graft body section and in fluid communication with the at least one channel, wherein the at least one inflatable porous cuff is disposed in an axisymmetric cylindrical manner around the proximal or distal end of the graft body section; providing an inflation medium including at least one therapeutic agent configured to be introduced into the inflatable channel;
wherein the inflation medium comprises a curable liquid comprising a therapeutic agent-carrying host polymer;implanting the graft body in a body lumen; and inflating the porous channel with the inflation medium including the at least one therapeutic agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method for delivering a therapeutic agent, said method comprising:
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providing an implant comprising; a graft comprising a graft body section having a proximal end, a distal end, and defining at least one inflatable porous channel therebetween; a connector member affixed to the proximal or distal end of the graft body section, the connector member comprising one or more connector elements; and a stent comprising one or more proximal stent connector elements coupled to the one or more connector member connector elements wherein the stent comprises a multi-crown configuration; providing a curable inflation medium including at least one therapeutic agent configured to be introduced into the inflatable channel, implanting the implant in a body lumen; and inflating the porous channel with the inflation medium including the at least one therapeutic agent. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19)
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Specification