Oxygen-effect free analyte sensor
First Claim
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1. An electrochemical sensor, comprising:
- a substrate comprising a working electrode and a counter electrode;
a co-factor associated dehydrogenase disposed on the working electrode, wherein the dehydrogenase reacts with an analyte of interest resulting in generation of free electrons; and
a redox mediator disposed proximate to the working electrode that assists in the transfer of the free electrons to the working electrode, wherein the redox mediator comprises a transition metal complex having the following formula;
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Abstract
The present invention provides an electrochemical sensor having a sensing chemistry that operates substantially free of any “oxygen effect”. The electrochemical sensors are useful in determining the level of an analyte in a biological sample from a subject. The present invention also provides sensor assemblies including the electrochemical sensors as well as methods of using the same.
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Citations
38 Claims
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1. An electrochemical sensor, comprising:
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a substrate comprising a working electrode and a counter electrode; a co-factor associated dehydrogenase disposed on the working electrode, wherein the dehydrogenase reacts with an analyte of interest resulting in generation of free electrons; and a redox mediator disposed proximate to the working electrode that assists in the transfer of the free electrons to the working electrode, wherein the redox mediator comprises a transition metal complex having the following formula; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. An analyte sensor assembly, comprising:
an electrochemical sensor comprising; a substrate comprising a working electrode and a counter electrode, a working electrode comprising a dehydrogenase disposed thereon, wherein the dehydrogenase reacts with an analyte of interest resulting in generation of free electrons; and a redox mediator disposed proximate to the working electrode that assists in the transfer of the free electrons to the working electrode, wherein the redox mediator comprises a transition metal complex having the following formula; - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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