Compositions and methods for the therapy and diagnosis of cytomegalovirus
First Claim
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1. A method for the treatment of a CMV infection in a subject, comprising administering to the subject a composition comprising an isolated anti-CMV antibody, wherein said antibody comprises,(a) a VH region comprising(i) a VH CDR1 region comprising the amino acid sequence of GFTFSS (SEQ ID NO:
- 60);
(ii) a VH CDR2 region comprising the amino acid sequence of VISSDANDKQ (SEQ ID NO;
61);
(iii) a VH CDR3 region comprising the amino acid sequence of DGTCSGGNCYSGLIDY (SEQ ID NO;
59); and
(b) a VL region comprising(i) a VL CDR1 region comprising the amino acid sequence of RASQSVGGYLA (SEQ ID NO;
43);
(ii) a VL CDR2 region comprising the amino acid sequence of ASIRAT (SEQ ID NO;
64);
(iii) a VL CDR3 region comprising the amino acid sequence of HQRSNWPPLT (SEQ ID NO;
65).
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Abstract
The present invention provides novel anti-cytomegalovirus antibodies and related compositions and methods. These antibodies may be used in the diagnosis, prevention, and treatment of cytomegalovirus infection.
64 Citations
10 Claims
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1. A method for the treatment of a CMV infection in a subject, comprising administering to the subject a composition comprising an isolated anti-CMV antibody, wherein said antibody comprises,
(a) a VH region comprising (i) a VH CDR1 region comprising the amino acid sequence of GFTFSS (SEQ ID NO: - 60);
(ii) a VH CDR2 region comprising the amino acid sequence of VISSDANDKQ (SEQ ID NO;
61);(iii) a VH CDR3 region comprising the amino acid sequence of DGTCSGGNCYSGLIDY (SEQ ID NO;
59); and(b) a VL region comprising (i) a VL CDR1 region comprising the amino acid sequence of RASQSVGGYLA (SEQ ID NO;
43);(ii) a VL CDR2 region comprising the amino acid sequence of ASIRAT (SEQ ID NO;
64);(iii) a VL CDR3 region comprising the amino acid sequence of HQRSNWPPLT (SEQ ID NO;
65). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- 60);
Specification