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Compositions and methods for the therapy and diagnosis of cytomegalovirus

  • US 8,268,309 B2
  • Filed: 05/17/2011
  • Issued: 09/18/2012
  • Est. Priority Date: 03/10/2008
  • Status: Expired due to Fees
First Claim
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1. A method for the treatment of a CMV infection in a subject, comprising administering to the subject a composition comprising an isolated anti-CMV antibody, wherein said antibody comprises,(a) a VH region comprising(i) a VH CDR1 region comprising the amino acid sequence of GFTFSS (SEQ ID NO:

  • 60);

    (ii) a VH CDR2 region comprising the amino acid sequence of VISSDANDKQ (SEQ ID NO;

         61);

    (iii) a VH CDR3 region comprising the amino acid sequence of DGTCSGGNCYSGLIDY (SEQ ID NO;

         59); and

    (b) a VL region comprising(i) a VL CDR1 region comprising the amino acid sequence of RASQSVGGYLA (SEQ ID NO;

         43);

    (ii) a VL CDR2 region comprising the amino acid sequence of ASIRAT (SEQ ID NO;

         64);

    (iii) a VL CDR3 region comprising the amino acid sequence of HQRSNWPPLT (SEQ ID NO;

         65).

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